HAMAP rule MF_01464
General rule information
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| Accession | MF_01464 |
| Dates | 5-JUL-2011 (Created) 17-FEB-2023 (Last updated, Version 9) |
| Name | SecF |
| Scope | Bacteria
Archaea |
| Templates | P0AG93 (SECF_ECOLI); Q5SKE6 (SECDF_THET8); E9RGS4 (SECF_VIBAL); D4GTK4 (SECF_HALVD); O32047 (SECDF_BACSU): [Recover all] |
case <OC:Bacteria>
| Triggered by |
end case
case <OC:Archaea>
| Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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| Gene name |
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Comments
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case <OC:Bacteria>
| Function | Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. |
else case <OC:Archaea>
| Function | Involved in protein export. |
end case
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
| Function | Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells. |
end case
case <OC:Pseudomonadota>
| Subunit | Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC. |
else case <OC:Bacteria>
| Subunit | Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved. |
else case <OC:Archaea>
| Subunit | Part of the protein translocation apparatus. Forms a complex with SecD. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the SecD/SecF family. SecF subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0065002; Biological process: intracellular protein transmembrane transport.
GO:0006605; Biological process: protein targeting.
GO:0006605; Biological process: protein targeting.
case <OC:Bacteria>
GO:0043952; Biological process: protein transport by the Sec complex.
end case
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| Pfam | PF07549; Sec_GG; 1; |
| PF02355; SecD_SecF; 1; | |
| PRINTS | PR01755; SECFTRNLCASE; 1; |
| TIGRFAMs | TIGR00916; 2A0604s01; 1; |
| TIGR00966; 3a0501s07; 1; |
Computed features
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| General | Transmembrane; -; 6; trigger=yes; |
Additional information
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case <OC:Bacteria>
| Size range | 270-475 amino acids |
end case
case <OC:Archaea>
| Size range | 250-390 amino acids |
end case
| Related rules | MF_01463 (SECD) |
| Fusion | Nter: MF_01463 (SecD); Cter: None |
| Comments | Often found as a SecDF fusion protein. In bacteria the operon consists of secDF. Some archaea have a secFD operon, in others the genes are separated on the genome. |