HAMAP rule MF_01465
General rule information
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Accession | MF_01465 |
Dates | 18-OCT-2011 (Created) 1-JUN-2023 (Last updated, Version 9) |
Name | SecY |
Scope | Bacteria
Archaea
Plastid |
Templates | Q60175 (SECY_METJA); O66491 (SECY_AQUAE); P0AGA2 (SECY_ECOLI); Q5SHQ8 (SECY_THET8); Q8U019 (SECY_PYRFU); Q9X1I9 (SECY_THEMA): [Recover all] |
case <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
case <OC:Bacteria> or <OG:Chloroplast>
Protein name |
|
else case <OC:Archaea>
Protein name |
|
end case
Gene name |
|
Comments
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case <OC:Bacteria> or <OC:Archaea>
Function | The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. |
else case <OG:Chloroplast>
Function | The central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. |
end case
case <OC:Bacteria>
Subunit | Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA. |
else case <OC:Archaea>
Subunit | Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved. |
else case <OG:Chloroplast>
Subunit | Component of the plastid Sec protein translocase complex, which is composed of at least SecY and SecE. |
end case
case <OG:Chloroplast>
Subcellular location | Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein. |
else case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. Cellular thylakoid membrane; Multi-pass membrane protein. |
else case <OC:Gloeobacter>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the SecY/SEC61-alpha family. |
Keywords
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case <OG:Chloroplast>
else case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
else case <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
else case <Property:Membrane=2>
end case
Gene Ontology
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GO:0065002; Biological process: intracellular protein transmembrane transport.
GO:0006605; Biological process: protein targeting.
GO:0006605; Biological process: protein targeting.
case <OC:Bacteria>
GO:0043952; Biological process: protein transport by the Sec complex.
end case
case <OC:Cyanobacteriota> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
else case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else
GO:0005886; Cellular component: plasma membrane.
end case
Cross-references
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PROSITE | PS00755; SECY_1; 1; |
PS00756; SECY_2; 1; | |
Pfam | PF10559; Plug_translocon; 1; |
PF00344; SecY; 1; | |
PRINTS | PR00303; SECYTRNLCASE; 1; |
NCBIfam | TIGR00967; 3a0501s007; 1; |
PIRSF | PIRSF004557; SecY; 1; |
Computed features
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General | Transmembrane; -; 10; trigger=yes; |
Additional information
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Size range | 340-661 amino acids |
Related rules | MF_01466 (SECY2) |
Fusion | None |
Comments | Unless there is a crystal structure we do not usually try to annotate the discontinuous transmembrane helix 2. A second, related SecY2 is encoded in some Staphylococcus and Streptococcus genomes (MF_01466); it is required for export of a large cell wall protein in the few organisms where it has been characterized. The 2 familes, while related, do not overlap. |