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Annotation rule MF_01465
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General rule information [?]

Accession MF_01465
Dates 18-OCT-2011 (Created)
19-NOV-2019 (Last updated, Version 7)
Name SecY
Scope
Bacteria
Archaea
Plastid
Templates Q60175 (SECY_METJA); O66491 (SECY_AQUAE); P0AGA2 (SECY_ECOLI); Q5SHQ8 (SECY_THET8); Q8U019 (SECY_PYRFU); Q9X1I9 (SECY_THEMA): [Recover all]
case <OC:Bacteria> or <OC:Archaea> or <OG:Chloroplast>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SECY
case <OC:Bacteria> or <OG:Chloroplast>
Protein name
RecName: Full=Protein translocase subunit SecY;
else case <OC:Archaea>
Protein name
RecName: Full=Protein translocase subunit SecY;
AltName: Full=Protein transport protein SEC61 subunit alpha homolog;
end case
Gene name
secY

Comments [?]

case <OC:Bacteria> or <OC:Archaea>
Function The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.
else case <OG:Chloroplast>
Function The central subunit of the protein translocation channel SecYE. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug.
end case
case <OC:Bacteria>
Subunit Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.
else case <OC:Archaea>
Subunit Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.
else case <OG:Chloroplast>
Subunit Component of the plastid Sec protein translocase complex, which is composed of at least SecY and SecE.
end case
case <OG:Chloroplast>
Subcellular location Plastid, chloroplast thylakoid membrane; Multi-pass membrane protein.
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
Subcellular location Cell inner membrane; Multi-pass membrane protein. Cellular thylakoid membrane; Multi-pass membrane protein.
else case <OC:Gloeobacter>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
else case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the SecY/SEC61-alpha family.

Keywords [?]

case <OG:Chloroplast>
else case <OC:Cyanobacteria> and not <OC:Gloeobacter>
else case <OC:Gloeobacter>
else case not defined <Property:Membrane> or <Property:Membrane=1>
else case <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0065002; Biological process: intracellular protein transmembrane transport.
GO:0006605; Biological process: protein targeting.
case <OC:Bacteria>
GO:0043952; Biological process: protein transport by the Sec complex.
end case
case <OC:Cyanobacteria> and not <OC:Gloeobacter>
GO:0042651; Cellular component: thylakoid membrane.
else case <OG:Chloroplast>
GO:0009535; Cellular component: chloroplast thylakoid membrane.
else
GO:0005886; Cellular component: plasma membrane.
end case

Cross-references [?]

PROSITE PS00755; SECY_1; 1;
PS00756; SECY_2; 1;
Pfam PF10559; Plug_translocon; 1;
PF00344; SecY; 1;
PRINTS PR00303; SECYTRNLCASE; 1;
TIGRFAMs TIGR00967; 3a0501s007; 1;
PIRSF PIRSF004557; SecY; 1;

Computed features [?]

General Transmembrane; -; 10; trigger=yes;

Additional information [?]

Size range 340-661 amino acids
Related rules MF_01466 (SECY2)
Fusion None
Comments Unless there is a crystal structure we do not usually try to annotate the discontinuous transmembrane helix 2. A second, related SecY2 is encoded in some Staphylococcus and Streptococcus genomes (MF_01466); it is required for export of a large cell wall protein in the few organisms where it has been characterized. The 2 familes, while related, do not overlap.