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HAMAP rule MF_01471

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General rule information [?]

Accession MF_01471
Dates 26-APR-2012 (Created)
1-JUN-2023 (Last updated, Version 12)
Name Cas2
Scope(s) Bacteria
Template(s) Q97YC2 (CAS2A_SACS2); Q82W51 (CAS2C_NITEU); Q9X2B6 (CAS2_THEMA); O28403 (CAS2A_ARCFU); O27155 (CAS2_METTH); Q97Y85 (CAS2B_SACS2); [ Recover all ]
Triggered by HAMAP; MF_01471 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CAS2
Protein name RecName: Full=CRISPR-associated endoribonuclease Cas2;
Gene name Name=cas2;

Comments [?]

FUNCTIONCRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
case <FT:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SUBUNITHomodimer, forms a heterotetramer with a Cas1 homodimer.
SIMILARITYBelongs to the CRISPR-associated endoribonuclease Cas2 protein family.

Keywords [?]

Gene Ontology [?]

GO:0004519; Molecular function:endonuclease activity
case <FT:1>
GO:0046872; Molecular function:metal ion binding
end case
GO:0051607; Biological process:defense response to virus
GO:0043571; Biological process:maintenance of CRISPR repeat elements

Cross-references [?]

Pfam PF09827; CRISPR_Cas2; 1;
NCBIfam TIGR01573; Cas2; 1;

Features [?]

From: CAS2A_SACS2 (Q97YC2)
Key From To Description Tag Condition FTGroup
BINDING 10 10 /ligand="Mg(2+)"

Additional information [?]

Size range 85-143 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments Found in almost all CRISPR systems. In Bacillus halodurans and Thermus thermophilus is a dsDNase.

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