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HAMAP rule MF_01471

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General rule information [?]

Accession MF_01471
Dates 26-APR-2012 (Created)
19-NOV-2022 (Last updated, Version 11)
Name Cas2
Scope
Bacteria
Archaea
Templates Q97YC2 (CAS2A_SACS2); Q82W51 (CAS2C_NITEU); Q9X2B6 (CAS2_THEMA); O28403 (CAS2A_ARCFU); O27155 (CAS2_METTH); Q97Y85 (CAS2B_SACS2): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CAS2
Protein name
RecName: Full=CRISPR-associated endoribonuclease Cas2;
EC 3.1.-.-;
Gene name
cas2

Comments [?]

Function CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
case <FT:1>
Cofactor Mg(2+)
end case
Subunit Homodimer, forms a heterotetramer with a Cas1 homodimer.
Similarity Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.

Keywords [?]

Antiviral defense
Endonuclease
Hydrolase
case <FT:1>
Magnesium
Metal-binding
end case
Nuclease

Gene Ontology [?]

GO:0004519; Molecular function: endonuclease activity.
case <FT:1>
GO:0046872; Molecular function: metal ion binding.
end case
GO:0051607; Biological process: defense response to virus.
GO:0043571; Biological process: maintenance of CRISPR repeat elements.

Cross-references [?]

Pfam PF09827; CRISPR_Cas2; 1;
TIGRFAMs TIGR01573; Cas2; 1;

Features [?]

From: CAS2A_SACS2 (Q97YC2)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     10     10       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_note="catalytic     [DE]  

Additional information [?]

Size range 85-143 amino acids
Related rules None
Fusion None
Comments Found in almost all CRISPR systems. In Bacillus halodurans and Thermus thermophilus is a dsDNase.


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