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Annotation rule MF_01472
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General rule information [?]

Accession MF_01472
Dates 14-JUN-2012 (Created)
19-NOV-2019 (Last updated, Version 9)
Name GtfA
Bacteria; Firmicutes
Templates A0A0H2URG7 (GTFA_STRPN); A0A0S4NM89 (GTFA_LACR5); A1C3L9 (GTFA_STRPA); Q3S2Y2 (GTFA_STRAG); Q9AET5 (GTFA_STRGN): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase GtfA subunit;
EC 2.4.1.-;
AltName: Full=Glycosyltransferase GtfA;
Gene name

Comments [?]

Function Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. Catalyzes the first step in glycosylation by transferring N-acetylglucosamine from UDP-GlcNAc to serine residues in the substrate protein. Part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon.
Catalytic activity RHEA:59872: L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-[N-acetyl-alpha-D-glucosaminyl]-L-seryl-[protein] + H(+) + UDP
Pathway Protein modification; protein glycosylation.
Subunit Forms a heterotetramer with 2 subunits each of GtfA and GtfB. Part of the accessory SecA2/SecY2 protein translocation apparatus.
Subcellular location Cytoplasm. Cell membrane; Peripheral membrane protein. Note=Cell membrane association requires GtfB.
Similarity Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0018242; Biological process: protein O-linked glycosylation via serine.
GO:0016757; Molecular function: transferase activity, transferring glycosyl groups.
GO:0017122; Cellular component: protein N-acetylglucosaminyltransferase complex.
GO:0005886; Cellular component: plasma membrane.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00534; Glycos_transf_1; 1;
TIGRFAMs TIGR02918; TIGR02918; 1;

Features [?]

Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     16     19       UDP     G-V-E-Y  
NP_BIND     384     385       UDP     [HQ]-[AHKQRVY]  
REGION     404     407       N-acetyl-D-glucosamine binding     E-G-F-G  
BINDING     242     242       N-acetyl-D-glucosamine     H  

Additional information [?]

Size range 490-548 amino acids
Related rules None
Fusion None