HAMAP rule MF_01473

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01473
Accession	MF_01473
Dates	14-JUN-2012 (Created) 02-FEB-2024 (Last updated, Version 12)
Name	GtfB
Scope(s)	Bacteria Bacillota
Template(s)	A0A0H2UR90; A1C3M0; Q3S2Y1; Q79T00; [ Recover all ]
Triggered by	HAMAP; MF_01473 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GTFB
Protein name	RecName: Full=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase stabilizing protein GtfB; AltName: Full=Glycosyltransferase stabilizing protein GtfB;
Gene name	Name=gtfB;

Comments [?]

FUNCTION	Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to the substrate protein, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA. Has no N-acetylglucosaminyl transferase activity on its own.
PATHWAY	Protein modification; protein glycosylation.
SUBUNIT	Forms a heterotetramer with 2 subunits each of GtfA and GtfB. Part of the accessory SecA2/SecY2 protein translocation apparatus.
SUBCELLULAR LOCATION	Cell membrane; Peripheral membrane protein.
SIMILARITY	Belongs to the GtfB family.

Keywords [?]

Gene Ontology [?]

GO:0018242; Biological process:protein O-linked glycosylation via serine

GO:0031647; Biological process:regulation of protein stability

GO:0017122; Cellular component:protein N-acetylglucosaminyltransferase complex

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF09318; DUF1975; 1;
NCBIfam	TIGR02919; TIGR02919; 1;

Features [?]

Additional information [?]