HAMAP rule MF_01473

General rule information [?]

Accession	MF_01473
Dates	14-JUN-2012 (Created) 13-JAN-2023 (Last updated, Version 9)

Name

GtfB

Scope

Bacteria; Bacillota

Templates

A0A0H2UR90 (GTFB_STRPN); A1C3M0 (GTFB_STRPA); Q3S2Y1 (GTFB_STRAG); Q79T00 (GTFB_STRGN): [Recover all]

Triggered by

HAMAP; MF_01473 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

GTFB

Protein name

RecName:		Full=UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase stabilizing protein GtfB;
AltName:		Full=Glycosyltransferase stabilizing protein GtfB;

Gene name

gtfB

Comments [?]

Function	Required for polymorphic O-glycosylation of the serine-rich repeat protein in this bacteria. A stabilizing protein that is part of the accessory SecA2/SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. The GtfA-GtfB complex adds GlcNAc from UDP-GlcNAc to the substrate protein, attaching the first sugar residue. Stabilizes the glycosylation activity of GtfA. Has no N-acetylglucosaminyl transferase activity on its own.
Pathway	Protein modification; protein glycosylation.
Subunit	Forms a heterotetramer with 2 subunits each of GtfA and GtfB. Part of the accessory SecA2/SecY2 protein translocation apparatus.
Subcellular location	Cell membrane; Peripheral membrane protein.
Similarity	Belongs to the GtfB family.

Keywords [?]

Cell membrane
Membrane

Gene Ontology [?]

GO:0017122; Cellular component: protein N-acetylglucosaminyltransferase complex.
GO:0031647; Biological process: regulation of protein stability.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF09318; DUF1975; 1;
TIGRFAMs	TIGR02919; TIGR02919; 1;

Additional information [?]

Size range	404-466 amino acids
Related rules	None
Fusion	None

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