HAMAP

Accession	MF_01479
Dates	8-OCT-2012 (Created) 19-NOV-2019 (Last updated, Version 11)

Name

WhiB

Scope

Bacteria; Actinobacteria

Templates

P9WF43 (WHIB1_MYCTU); P9WF41 (WHIB3_MYCTU); P9WF39 (WHIB4_MYCTU); Q7AKI9 (WHID_STRCO): [Recover all]

Triggered by

HAMAP; MF_01479 (Get profile general information and statistics)

Identifier

WHIB

Protein name

RecName: Full=Transcriptional regulator WhiB;

Gene name

whiB

Function	Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
Cofactor	[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
Subcellular location	Cytoplasm.
Ptm	The Fe-S cluster can be nitrosylated by nitric oxide (NO).
	Upon Fe-S cluster removal intramolecular disulfide bonds are formed.
Similarity	Belongs to the WhiB family.

4Fe-4S
Iron
Iron-sulfur
Metal-binding

Cytoplasm
Disulfide bond
DNA-binding
Transcription
Transcription regulation

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005737; Cellular component: cytoplasm.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0003677; Molecular function: DNA binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.

Pfam	PF02467; Whib; 1;

From: WHIB1_MYCTU (P9WF43)
Key		From		To		Description		Tag		Condition		FTGroup
METAL		9		9		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		9		9		Iron-sulfur (4Fe-4S); alternate				C		2
METAL		37		37		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		37		37		Iron-sulfur (4Fe-4S); alternate				C		2
METAL		40		40		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		40		40		Iron-sulfur (4Fe-4S); alternate				C		2
METAL		46		46		Dinitrosyliron [4Fe-8(NO)]; alternate				C		1
METAL		46		46		Iron-sulfur (4Fe-4S); alternate				C		2

Size range	76-306 amino acids
Related rules	None
Fusion	None

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