Home  |  Contact
Annotation rule MF_01479
Send feedback

General rule information [?]

Accession MF_01479
Dates 8-OCT-2012 (Created)
19-NOV-2019 (Last updated, Version 11)
Name WhiB
Scope
Bacteria; Actinobacteria
Templates P9WF43 (WHIB1_MYCTU); P9WF41 (WHIB3_MYCTU); P9WF39 (WHIB4_MYCTU); Q7AKI9 (WHID_STRCO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
WHIB
Protein name
RecName: Full=Transcriptional regulator WhiB;
Gene name
whiB

Comments [?]

Function Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
Subcellular location Cytoplasm.
Ptm The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.
Similarity Belongs to the WhiB family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005737; Cellular component: cytoplasm.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0003677; Molecular function: DNA binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.

Cross-references [?]

Pfam PF02467; Whib; 1;

Features [?]

From: WHIB1_MYCTU (P9WF43)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     9     9       Dinitrosyliron [4Fe-8(NO)]; alternate     C   1
METAL     9     9       Iron-sulfur (4Fe-4S); alternate     C   2
METAL     37     37       Dinitrosyliron [4Fe-8(NO)]; alternate     C   1
METAL     37     37       Iron-sulfur (4Fe-4S); alternate     C   2
METAL     40     40       Dinitrosyliron [4Fe-8(NO)]; alternate     C   1
METAL     40     40       Iron-sulfur (4Fe-4S); alternate     C   2
METAL     46     46       Dinitrosyliron [4Fe-8(NO)]; alternate     C   1
METAL     46     46       Iron-sulfur (4Fe-4S); alternate     C   2

Additional information [?]

Size range 76-306 amino acids
Related rules None
Fusion None