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Annotation rule MF_01479 |
Accession | MF_01479 |
Dates | 8-OCT-2012 (Created) 19-NOV-2019 (Last updated, Version 11) |
Name | WhiB |
Scope | Bacteria; Actinobacteria |
Templates | P9WF43 (WHIB1_MYCTU); P9WF41 (WHIB3_MYCTU); P9WF39 (WHIB4_MYCTU); Q7AKI9 (WHID_STRCO): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA. |
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit. |
Subcellular location | Cytoplasm. |
Ptm | The Fe-S cluster can be nitrosylated by nitric oxide (NO). |
Upon Fe-S cluster removal intramolecular disulfide bonds are formed. | |
Similarity | Belongs to the WhiB family. |
Pfam | PF02467; Whib; 1; |
From: WHIB1_MYCTU (P9WF43) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
METAL | 9 | 9 | Dinitrosyliron [4Fe-8(NO)]; alternate | C | 1 | |||||||
METAL | 9 | 9 | Iron-sulfur (4Fe-4S); alternate | C | 2 | |||||||
METAL | 37 | 37 | Dinitrosyliron [4Fe-8(NO)]; alternate | C | 1 | |||||||
METAL | 37 | 37 | Iron-sulfur (4Fe-4S); alternate | C | 2 | |||||||
METAL | 40 | 40 | Dinitrosyliron [4Fe-8(NO)]; alternate | C | 1 | |||||||
METAL | 40 | 40 | Iron-sulfur (4Fe-4S); alternate | C | 2 | |||||||
METAL | 46 | 46 | Dinitrosyliron [4Fe-8(NO)]; alternate | C | 1 | |||||||
METAL | 46 | 46 | Iron-sulfur (4Fe-4S); alternate | C | 2 |
Size range | 76-306 amino acids |
Related rules | None |
Fusion | None |