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HAMAP rule MF_01479

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General rule information [?]

Accession MF_01479
Dates 8-OCT-2012 (Created)
13-JAN-2023 (Last updated, Version 16)
Name WhiB
Scope(s) Bacteria
Template(s) P9WF43 (WHIB1_MYCTU); P9WF41 (WHIB3_MYCTU); P9WF39 (WHIB4_MYCTU); Q7AKI9 (WHID_STRCO); [ Recover all ]
Triggered by HAMAP; MF_01479 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier WHIB
Protein name RecName: Full=Transcriptional regulator WhiB;
Gene name Name=whiB;

Comments [?]

FUNCTIONActs as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
COFACTOR Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.;
PTMThe Fe-S cluster can be nitrosylated by nitric oxide (NO).
PTMUpon Fe-S cluster removal intramolecular disulfide bonds are formed.
SIMILARITYBelongs to the WhiB family.

Keywords [?]

Gene Ontology [?]

GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
GO:0005737; Cellular component:cytoplasm
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0003677; Molecular function:DNA binding
GO:0035731; Molecular function:dinitrosyl-iron complex binding

Cross-references [?]

Pfam PF02467; Whib; 1;

Features [?]

From: WHIB1_MYCTU (P9WF43)
Key From To Description Tag Condition FTGroup
BINDING 9 9 /ligand="[4Fe-4S] cluster"
C 1
BINDING 37 37 /ligand="[4Fe-4S] cluster"
C 1
BINDING 40 40 /ligand="[4Fe-4S] cluster"
C 1
BINDING 46 46 /ligand="[4Fe-4S] cluster"
C 1

Additional information [?]

Size range 76-306 amino acids
Related rules None
Fusion Nter: None Cter: None

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