HAMAP rule MF_01479
General rule information
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Accession | MF_01479 |
Dates | 8-OCT-2012 (Created) 13-JAN-2023 (Last updated, Version 16) |
Name | WhiB |
Scope | Bacteria; Actinomycetota |
Templates | P9WF43 (WHIB1_MYCTU); P9WF41 (WHIB3_MYCTU); P9WF39 (WHIB4_MYCTU); Q7AKI9 (WHID_STRCO): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA. |
Cofactor | [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit. |
Subcellular location | Cytoplasm. |
Ptm | The Fe-S cluster can be nitrosylated by nitric oxide (NO). |
Upon Fe-S cluster removal intramolecular disulfide bonds are formed. | |
Similarity | Belongs to the WhiB family. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005737; Cellular component: cytoplasm.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0003677; Molecular function: DNA binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.
GO:0005737; Cellular component: cytoplasm.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0003677; Molecular function: DNA binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.
Cross-references
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Pfam | PF02467; Whib; 1; |
Features
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From: WHIB1_MYCTU (P9WF43) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 9 | 9 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 37 | 37 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 40 | 40 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 | |||||||
BINDING | 46 | 46 | /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 | C | 1 |
Additional information
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Size range | 76-306 amino acids |
Related rules | None |
Fusion | None |