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HAMAP rule MF_01479

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General rule information [?]

Accession MF_01479
Dates 8-OCT-2012 (Created)
13-JAN-2023 (Last updated, Version 16)
Name WhiB
Bacteria; Actinomycetota
Templates P9WF43 (WHIB1_MYCTU); P9WF41 (WHIB3_MYCTU); P9WF39 (WHIB4_MYCTU); Q7AKI9 (WHID_STRCO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Transcriptional regulator WhiB;
Gene name

Comments [?]

Function Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.
Cofactor [4Fe-4S] cluster
Note: Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.
Subcellular location Cytoplasm.
Ptm The Fe-S cluster can be nitrosylated by nitric oxide (NO).
Upon Fe-S cluster removal intramolecular disulfide bonds are formed.
Similarity Belongs to the WhiB family.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

GO:0051539; Molecular function: 4 iron, 4 sulfur cluster binding.
GO:0005737; Cellular component: cytoplasm.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0003677; Molecular function: DNA binding.
GO:0035731; Molecular function: dinitrosyl-iron complex binding.

Cross-references [?]

Pfam PF02467; Whib; 1;

Features [?]

From: WHIB1_MYCTU (P9WF43)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     9     9       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     37     37       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     40     40       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1
BINDING     46     46       /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883     C   1

Additional information [?]

Size range 76-306 amino acids
Related rules None
Fusion None