HAMAP rule MF_01479

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01479
Accession	MF_01479
Dates	08-OCT-2012 (Created) 13-JAN-2023 (Last updated, Version 17)
Name	WhiB
Scope(s)	Bacteria Actinomycetota
Template(s)	P9WF43; P9WF41; P9WF39; Q7AKI9; [ Recover all ]
Triggered by	HAMAP; MF_01479 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	WHIB
Protein name	RecName: Full=Transcriptional regulator WhiB;
Gene name	Name=whiB;

Comments [?]

FUNCTION	Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA.
COFACTOR	Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Note=Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.;
SUBCELLULAR LOCATION	Cytoplasm.
PTM	The Fe-S cluster can be nitrosylated by nitric oxide (NO).
PTM	Upon Fe-S cluster removal intramolecular disulfide bonds are formed.
SIMILARITY	Belongs to the WhiB family.

Keywords [?]

Gene Ontology [?]

GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding

GO:0005737; Cellular component:cytoplasm

GO:0006355; Biological process:regulation of DNA-templated transcription

GO:0003677; Molecular function:DNA binding

GO:0035731; Molecular function:dinitrosyl-iron complex binding

Cross-references [?]

Pfam	PF02467; Whib; 1;

Features [?]

From: WHIB1_MYCTU (P9WF43)

Key

From

Description

Tag

Condition

FTGroup

BINDING

/ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"

BINDING

/ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"

BINDING

/ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"

BINDING

/ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"

Additional information [?]