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Annotation rule MF_01482
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General rule information [?]

Accession MF_01482
Dates 13-JUN-2013 (Created)
19-NOV-2019 (Last updated, Version 8)
Name Mca
Scope
Bacteria; Actinobacteria
Templates A0R2W9 (MCA_MYCS2); P9WJN1 (MCA_MYCTU); Q9ADK0 (MCA_STRCO): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MCA
Protein name
RecName: Full=Mycothiol S-conjugate amidase;
EC 3.5.1.115;
Gene name
mca

Comments [?]

Function A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
Catalytic activity RHEA:36543: H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate
EC 3.5.1.115
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Subunit Monomer.
Similarity Belongs to the MshB deacetylase family. Mca subfamily.

Keywords [?]


Gene Ontology [?]

GO:0008270; Molecular function: zinc ion binding.
GO:0010126; Biological process: mycothiol metabolic process.
GO:0010127; Biological process: mycothiol-dependent detoxification.

Cross-references [?]

Pfam PF02585; PIG-L; 1;
TIGRFAMs TIGR03446; mycothiol_Mca; 1;

Features [?]

From: MCA_MYCTU (P9WJN1)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     12     12       Zinc     H  
METAL     15     15       Zinc     D  
METAL     142     142       Zinc     H  

Additional information [?]

Size range 255-420 amino acids
Related rules None
Fusion None