HAMAP rule MF_01482
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01482 |
| Accession | MF_01482 |
| Dates | 13-JUN-2013 (Created)
10-JUN-2025 (Last updated, Version 15) |
| Name | Mca |
| Scope(s) |
Bacteria Actinomycetota |
| Template(s) | A0R2W9; P9WJN1; Q9ADK0; [ Recover all ] |
| Triggered by |
HAMAP; MF_01482 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MCA |
| Protein name | RecName: Full=Mycothiol S-conjugate amidase; EC=3.5.1.115; |
| Gene name | Name=mca; |
Comments
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| FUNCTION | A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics. |
| CATALYTIC ACTIVITY | Reaction=mycothiol S-conjugate + H2O = an N-acetyl-L-cysteine-S- conjugate + 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside; Xref=Rhea:RHEA:36543, ChEBI:CHEBI:15377, ChEBI:CHEBI:58718, ChEBI:CHEBI:58886, ChEBI:CHEBI:59633; EC=3.5.1.115; |
| COFACTOR | Name=Fe(2+); Xref=ChEBI:CHEBI:29033; |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the MshB deacetylase family. Mca subfamily. |
Keywords
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Gene Ontology
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| GO:0008270; Molecular function:zinc ion binding |
| GO:0010126; Biological process:mycothiol metabolic process |
| GO:0010127; Biological process:mycothiol-dependent detoxification |
Cross-references
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Features
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| From: MCA_MYCTU (P9WJN1) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 12 | 12 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" |
H | ||||||||
| BINDING | 15 | 15 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" |
D | ||||||||
| BINDING | 142 | 142 | /ligand="Fe(2+)" /ligand_id="ChEBI:CHEBI:29033" |
H | ||||||||
Additional information
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| Size range | 255-420 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |