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HAMAP rule MF_01482

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General rule information [?]

Accession MF_01482
Dates 13-JUN-2013 (Created)
1-JUN-2023 (Last updated, Version 12)
Name Mca
Scope(s) Bacteria
Template(s) A0R2W9 (MCA_MYCS2); P9WJN1 (MCA_MYCTU); Q9ADK0 (MCA_STRCO); [ Recover all ]
Triggered by HAMAP; MF_01482 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MCA
Protein name RecName: Full=Mycothiol S-conjugate amidase;
Gene name Name=mca;

Comments [?]

FUNCTIONA mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S- conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.
CATALYTIC ACTIVITY Reaction=H2O + mycothiol S-conjugate = 1D-myo-inositol 2-amino-2-deoxy- alpha-D-glucopyranoside + an N-acetyl-L-cysteine-S-conjugate; Xref=Rhea:RHEA:36543, ChEBI:CHEBI:15377, ChEBI:CHEBI:58718, ChEBI:CHEBI:58886, ChEBI:CHEBI:59633; EC=;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
SIMILARITYBelongs to the MshB deacetylase family. Mca subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008270; Molecular function:zinc ion binding
GO:0010126; Biological process:mycothiol metabolic process
GO:0010127; Biological process:mycothiol-dependent detoxification

Cross-references [?]

Pfam PF02585; PIG-L; 1;
NCBIfam TIGR03446; mycothiol_Mca; 1;

Features [?]

Key From To Description Tag Condition FTGroup
BINDING 12 12 /ligand="Zn(2+)"
BINDING 15 15 /ligand="Zn(2+)"
BINDING 142 142 /ligand="Zn(2+)"

Additional information [?]

Size range 255-420 amino acids
Related rules None
Fusion Nter: None Cter: None

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