HAMAP rule MF_01484
General rule information
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Accession | MF_01484 |
Dates | 10-OCT-2013 (Created) 19-NOV-2019 (Last updated, Version 6) |
Name | AcrZ |
Scope | Bacteria; Enterobacterales |
Template | P0AAW9 (ACRZ_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. |
Subunit | Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB. |
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location | Cell membrane; Single-pass membrane protein. |
else case <Property:Membrane=2>
Subcellular location | Cell inner membrane; Single-pass membrane protein. |
end case
Similarity | Belongs to the AcrZ family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0042910; Molecular function: xenobiotic transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Pfam | PF10766; DUF2592; 1; |
Computed features
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General | Transmembrane; -; 1; trigger=yes; |
Additional information
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Size range | 41-83 amino acids |
Related rules | None |
Fusion | None |
Comments | The protein is probably about 50 residues long, longer versions have a too long N-terminal. |