HAMAP rule MF_01484
General rule information
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| Accession | MF_01484 |
| Dates | 10-OCT-2013 (Created)
19-NOV-2019 (Last updated, Version 6) |
| Name | AcrZ |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P0AAW9 (ACRZ_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01484 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ACRZ |
| Protein name | RecName: Full=Multidrug efflux pump accessory protein AcrZ; AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ; AltName: Full=Acridine resistance protein Z; |
| Gene name | Name=acrZ; |
Comments
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| FUNCTION | AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export. |
| SUBUNIT | Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB. |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the AcrZ family. |
Keywords
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| Antibiotic resistance | |
| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Membrane | |
| Transmembrane | |
| Transmembrane helix | |
| Transport | |
Gene Ontology
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| GO:0042910; Molecular function:xenobiotic transmembrane transporter activity |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF10766; DUF2592; 1; |
| General | Transmembrane; -; 1; |
Features
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Additional information
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| Size range | 41-83 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | The protein is probably about 50 residues long, longer versions have a too long N-terminal. |