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HAMAP rule MF_01484

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General rule information [?]

Accession MF_01484
Dates 10-OCT-2013 (Created)
19-NOV-2019 (Last updated, Version 6)
Name AcrZ
Scope(s) Bacteria
Template(s) P0AAW9 (ACRZ_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01484 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACRZ
Protein name RecName: Full=Multidrug efflux pump accessory protein AcrZ;
AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ;
AltName: Full=Acridine resistance protein Z;
Gene name Name=acrZ;

Comments [?]

FUNCTIONAcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
SUBUNITPart of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
end case
SIMILARITYBelongs to the AcrZ family.

Keywords [?]

Antibiotic resistance
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0042910; Molecular function:xenobiotic transmembrane transporter activity
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF10766; DUF2592; 1;
General Transmembrane; -; 1;

Features [?]

Additional information [?]

Size range 41-83 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments The protein is probably about 50 residues long, longer versions have a too long N-terminal.

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