HAMAP rule MF_01484

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01484
Accession	MF_01484
Dates	10-OCT-2013 (Created) 13-MAY-2025 (Last updated, Version 8)
Name	AcrZ
Scope(s)	Bacteria Enterobacterales
Template(s)	P0AAW9; [ Recover all ]
Triggered by	HAMAP; MF_01484 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	ACRZ
Protein name	RecName: Full=Multidrug efflux pump accessory protein AcrZ; AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ; AltName: Full=Acridine resistance protein Z;
Gene name	Name=acrZ;

Comments [?]

FUNCTION	Accessory component of the AcrABZ-TolC efflux protein complex, which has a broad substrate specificity. Binds to AcrB and perhaps together with membrane lipids, such as cardiolipin, influences the specificity of substrate export.
SUBUNIT	Component of the AcrABZ-TolC efflux pump complex.
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Single-pass membrane protein.
end case
SIMILARITY	Belongs to the AcrZ family.

Keywords [?]

Antibiotic resistance
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Transmembrane
Transmembrane helix
Transport

Gene Ontology [?]

GO:0042910; Molecular function:xenobiotic transmembrane transporter activity

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam	PF10766; DUF2592; 1;
General	Transmembrane; -; 1;

Features [?]

Additional information [?]

Size range	41-83 amino acids
Related rules	None
Fusion	Nter: None Cter: None
Comments	The protein is probably about 50 residues long, longer versions have a too long N-terminal.