HAMAP rule MF_01484

General rule information [?]

Accession	MF_01484
Dates	10-OCT-2013 (Created) 19-NOV-2019 (Last updated, Version 6)

Name

AcrZ

Scope

Bacteria; Enterobacterales

Template

P0AAW9 (ACRZ_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

ACRZ

Protein name

RecName:		Full=Multidrug efflux pump accessory protein AcrZ;
AltName:		Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ;
AltName:		Full=Acridine resistance protein Z;

Gene name

acrZ

Comments [?]

Function	AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
Subunit	Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.

case not defined <Property:Membrane> or <Property:Membrane=1>

Subcellular location

Cell membrane; Single-pass membrane protein.

else case <Property:Membrane=2>

Subcellular location

Cell inner membrane; Single-pass membrane protein.

end case

Similarity

Belongs to the AcrZ family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>

end case

Gene Ontology [?]

GO:0042910; Molecular function: xenobiotic transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF10766; DUF2592; 1;

Computed features [?]

General

Transmembrane; -; 1; trigger=yes;

Additional information [?]

Size range	41-83 amino acids
Related rules	None
Fusion	None
Comments	The protein is probably about 50 residues long, longer versions have a too long N-terminal.