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HAMAP rule MF_01484

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General rule information [?]

Accession MF_01484
Dates 10-OCT-2013 (Created)
19-NOV-2019 (Last updated, Version 6)
Name AcrZ
Bacteria; Enterobacterales
Template P0AAW9 (ACRZ_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Multidrug efflux pump accessory protein AcrZ;
AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ;
AltName: Full=Acridine resistance protein Z;
Gene name

Comments [?]

Function AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
Subunit Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts directly with AcrB.
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Single-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Single-pass membrane protein.
end case
Similarity Belongs to the AcrZ family.

Keywords [?]

case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0042910; Molecular function: xenobiotic transmembrane transporter activity.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF10766; DUF2592; 1;

Computed features [?]

General Transmembrane; -; 1; trigger=yes;

Additional information [?]

Size range 41-83 amino acids
Related rules None
Fusion None
Comments The protein is probably about 50 residues long, longer versions have a too long N-terminal.