HAMAP rule MF_01486
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01486 |
| Accession | MF_01486 |
| Dates | 16-DEC-2013 (Created)
10-NOV-2023 (Last updated, Version 17) |
| Name | RecC |
| Scope(s) |
Bacteria Actinomycetota Bacteroidota Chlamydiota Chlorobiota Deferribacteres Pseudomonadota Spirochaetota |
| Template(s) | P07648; [ Recover all ] |
| Triggered by |
HAMAP; MF_01486 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | RECC |
| Protein name | RecName: Full=RecBCD enzyme subunit RecC; AltName: Full=Exonuclease V subunit RecC; Short=ExoV subunit RecC; AltName: Full=Helicase/nuclease RecBCD subunit RecC; |
| Gene name | Name=recC; |
Comments
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| FUNCTION | A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity. |
| SUBUNIT | Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. |
| MISCELLANEOUS | In the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'- 3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site. |
| SIMILARITY | Belongs to the RecC family. |
Keywords
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| ATP-binding |
| DNA damage |
| DNA repair |
| DNA-binding |
| Exonuclease |
| Helicase |
| Hydrolase |
| Nuclease |
| Nucleotide-binding |
Gene Ontology
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| GO:0003678; Molecular function:DNA helicase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0003677; Molecular function:DNA binding |
| GO:0000724; Biological process:double-strand break repair via homologous recombination |
Cross-references
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| Pfam | PF04257; Exonuc_V_gamma; 1; |
| Pfam | PF17946; RecC_C; 1; |
| NCBIfam | TIGR01450; recC; 1; |
| PIRSF | PIRSF000980; RecC; 1; |
Features
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Additional information
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| Size range | 1028-1375 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |