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Annotation rule MF_01486 |
Accession | MF_01486 |
Dates | 16-DEC-2013 (Created) 19-NOV-2019 (Last updated, Version 10) |
Name | RecC |
Scope | Bacteria; Actinobacteria
Bacteria; Bacteroidetes
Bacteria; Chlorobi
Bacteria; Deferribacteres
Bacteria; Proteobacteria |
Template | P07648 (RECC_ECOLI) |
Triggered by |
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Function | A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity. |
Catalytic activity | Reaction=Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.; EC=3.1.11.5; |
Subunit | Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. |
Similarity | Belongs to the RecC family. |
TIGRFAMs | TIGR01450; recC; 1; |
PIRSF | PIRSF000980; RecC; 1; |
Size range | 1028-1375 amino acids |
Related rules | None |
Fusion | None |