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Annotation rule MF_01486
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General rule information [?]

Accession MF_01486
Dates 16-DEC-2013 (Created)
19-NOV-2019 (Last updated, Version 10)
Name RecC
Scope
Bacteria; Actinobacteria
Bacteria; Bacteroidetes
Bacteria; Chlorobi
Bacteria; Deferribacteres
Bacteria; Proteobacteria
Template P07648 (RECC_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RECC
Protein name
RecName: Full=RecBCD enzyme subunit RecC;
EC 3.1.11.5;
AltName: Full=Exonuclease V subunit RecC;
Short=ExoV subunit RecC;
AltName: Full=Helicase/nuclease RecBCD subunit RecC;
Gene name
recC

Comments [?]

Function A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
Catalytic activity Reaction=Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.; EC=3.1.11.5;
Subunit Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.
Similarity Belongs to the RecC family.

Keywords [?]

ATP-binding
DNA damage
DNA repair
DNA-binding
Exonuclease
Helicase
Hydrolase
Nuclease
Nucleotide-binding

Gene Ontology [?]

GO:0003678; Molecular function: DNA helicase activity.
GO:0005524; Molecular function: ATP binding.
GO:0003677; Molecular function: DNA binding.
GO:0000724; Biological process: double-strand break repair via homologous recombination.

Cross-references [?]

TIGRFAMs TIGR01450; recC; 1;
PIRSF PIRSF000980; RecC; 1;

Additional information [?]

Size range 1028-1375 amino acids
Related rules None
Fusion None


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