HAMAP rule MF_01486
General rule information
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Accession | MF_01486 |
Dates | 16-DEC-2013 (Created)
1-JUN-2023 (Last updated, Version 15) |
Name | RecC |
Scope(s) |
Bacteria Actinomycetota Bacteroidota Chlorobiota Deferribacteres Pseudomonadota |
Template(s) | P07648 (RECC_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01486 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | RECC |
RecName: Full=RecBCD enzyme subunit RecC;<br /> EC=<a href="https://enzyme.expasy.org/EC/3.1.11.5">3.1.11.5</a>;<br /> AltName: Full=Exonuclease V subunit RecC;<br /> Short=ExoV subunit RecC;<br /> AltName: Full=Helicase/nuclease RecBCD subunit RecC; | |
Gene name | Name=recC; |
Comments
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FUNCTION | A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity. |
CATALYTIC ACTIVITY | Reaction=Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'- phosphooligonucleotides.; EC=3.1.11.5; |
SUBUNIT | Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. |
SIMILARITY | Belongs to the RecC family. |
Keywords
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ATP-binding | |
DNA damage | |
DNA repair | |
DNA-binding | |
Exonuclease | |
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
Hydrolase | |
Nuclease | |
Nucleotide-binding |
Gene Ontology
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GO:0003678; Molecular function:DNA helicase activity |
GO:0005524; Molecular function:ATP binding |
GO:0003677; Molecular function:DNA binding |
GO:0000724; Biological process:double-strand break repair via homologous recombination |
Cross-references
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NCBIfam | TIGR01450; recC; 1; |
PIRSF | PIRSF000980; RecC; 1; |
Features
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Additional information
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Size range | 1028-1375 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |