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HAMAP rule MF_01486

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General rule information [?]

Accession MF_01486
Dates 16-DEC-2013 (Created)
10-NOV-2023 (Last updated, Version 16)
Name RecC
Scope(s) Bacteria
Template(s) P07648 (RECC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01486 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier RECC
RecName: Full=RecBCD enzyme subunit RecC;<br /> AltName: Full=Exonuclease V subunit RecC;<br /> &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Short=ExoV subunit RecC;<br /> AltName: Full=Helicase/nuclease RecBCD subunit RecC;
Gene name Name=recC;

Comments [?]

FUNCTIONA helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.
SUBUNITHeterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.
MISCELLANEOUSIn the RecBCD complex, RecB has a slow 3'-5' helicase, an exonuclease activity and loads RecA onto ssDNA, RecD has a fast 5'- 3' helicase activity, while RecC stimulates the ATPase and processivity of the RecB helicase and contributes to recognition of the Chi site.
SIMILARITYBelongs to the RecC family.

Keywords [?]

DNA damage
DNA repair
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a>

Gene Ontology [?]

GO:0003678; Molecular function:DNA helicase activity
GO:0005524; Molecular function:ATP binding
GO:0003677; Molecular function:DNA binding
GO:0000724; Biological process:double-strand break repair via homologous recombination

Cross-references [?]

Pfam PF04257; Exonuc_V_gamma; 1;
Pfam PF17946; RecC_C; 1;
NCBIfam TIGR01450; recC; 1;
PIRSF PIRSF000980; RecC; 1;

Features [?]

Additional information [?]

Size range 1028-1375 amino acids
Related rules None
Fusion Nter: None Cter: None

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