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HAMAP rule MF_01497

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General rule information [?]

Accession MF_01497
Dates 30-APR-2015 (Created)
19-NOV-2022 (Last updated, Version 7)
Name SrkA_kinase
Scope(s) Bacteria
Template(s) P0C0K3 (SRKA_ECOLI); Q8ZKU8 (RDOA_SALTY); Q83IV7 (SRKA_SHIFL); [ Recover all ]
Triggered by HAMAP; MF_01497 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SRKA
Protein name RecName: Full=Stress response kinase A;
AltName: Full=Serine/threonine-protein kinase SrkA;
Gene name Name=srkA;

Comments [?]

FUNCTIONA protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
CATALYTIC ACTIVITY Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=;
CATALYTIC ACTIVITY Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=;
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
SIMILARITYBelongs to the SrkA/RdoA protein kinase family.

Keywords [?]

Gene Ontology [?]

GO:0004674; Molecular function:protein serine/threonine kinase activity
GO:0005524; Molecular function:ATP binding
GO:0000287; Molecular function:magnesium ion binding
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF01636; APH; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 201 201 /note="Proton acceptor" D
ACT_SITE 217 217 D
BINDING 206 206 /ligand="Mg(2+)"
BINDING 217 217 /ligand="Mg(2+)"
SITE 36 36 /note="ATP" S

Additional information [?]

Size range 280-416 amino acids
Related rules None
Fusion Nter: None Cter: None

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