HAMAP rule MF_01497
General rule information
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Accession | MF_01497 |
Dates | 30-APR-2015 (Created)
19-NOV-2022 (Last updated, Version 7) |
Name | SrkA_kinase |
Scope(s) |
Bacteria |
Template(s) | P0C0K3 (SRKA_ECOLI); Q8ZKU8 (RDOA_SALTY); Q83IV7 (SRKA_SHIFL); [ Recover all ] |
Triggered by |
HAMAP; MF_01497 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SRKA |
Protein name | RecName: Full=Stress response kinase A; EC=2.7.11.1; AltName: Full=Serine/threonine-protein kinase SrkA; |
Gene name | Name=srkA; |
Comments
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FUNCTION | A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. |
CATALYTIC ACTIVITY | Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl- [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; |
CATALYTIC ACTIVITY | Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L- threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
SUBUNIT | Monomer. |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the SrkA/RdoA protein kinase family. |
Keywords
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ATP-binding |
Cytoplasm |
Kinase |
Magnesium |
Metal-binding |
Nucleotide-binding |
Phosphoprotein |
Serine/threonine-protein kinase |
Stress response |
Transferase |
Gene Ontology
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GO:0004674; Molecular function:protein serine/threonine kinase activity |
GO:0005524; Molecular function:ATP binding |
GO:0000287; Molecular function:magnesium ion binding |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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Pfam | PF01636; APH; 1; |
Features
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From: SRKA_ECOLI (P0C0K3) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 201 | 201 | /note="Proton acceptor" | D | ||||||||
ACT_SITE | 217 | 217 | D | |||||||||
BINDING | 206 | 206 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
BINDING | 217 | 217 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
SITE | 36 | 36 | /note="ATP" | S |
Additional information
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Size range | 280-416 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |