HAMAP rule MF_01497
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_01497 |
| Accession | MF_01497 |
| Dates | 30-APR-2015 (Created)
02-SEP-2024 (Last updated, Version 9) |
| Name | SrkA_kinase |
| Scope(s) |
Bacteria |
| Template(s) | P0C0K3; Q8ZKU8; Q83IV7; [ Recover all ] |
| Triggered by |
HAMAP; MF_01497 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | SRKA |
| Protein name | RecName: Full=Stress response kinase A; EC=2.7.11.1; AltName: Full=Serine/threonine-protein kinase SrkA; |
| Gene name | Name=srkA; |
Comments
[?]
| FUNCTION | A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. |
| CATALYTIC ACTIVITY | Reaction=L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+); Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA- COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| CATALYTIC ACTIVITY | Reaction=L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+); Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013, ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216; EC=2.7.11.1; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| SUBUNIT | Monomer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the SrkA/RdoA protein kinase family. |
Keywords
[?]
| ATP-binding |
| Cytoplasm |
| Kinase |
| Magnesium |
| Metal-binding |
| Nucleotide-binding |
| Phosphoprotein |
| Serine/threonine-protein kinase |
| Stress response |
| Transferase |
Gene Ontology
[?]
| GO:0004674; Molecular function:protein serine/threonine kinase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0000287; Molecular function:magnesium ion binding |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
| Pfam | PF01636; APH; 1; |
Features
[?]
| From: SRKA_ECOLI (P0C0K3) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 201 | 201 | /note="Proton acceptor" | D | ||||||||
| ACT_SITE | 217 | 217 | D | |||||||||
| BINDING | 206 | 206 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
N | ||||||||
| BINDING | 217 | 217 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
D | ||||||||
| SITE | 36 | 36 | /note="ATP" | S | ||||||||
Additional information
[?]
| Size range | 280-416 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |