HAMAP rule MF_01497

General rule information [?]

Accession	MF_01497
Dates	30-APR-2015 (Created) 19-NOV-2022 (Last updated, Version 7)

Name	SrkA_kinase

Scope

Bacteria

Templates

P0C0K3 (SRKA_ECOLI); Q8ZKU8 (RDOA_SALTY); Q83IV7 (SRKA_SHIFL): [Recover all]

Triggered by

HAMAP; MF_01497 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SRKA

Protein name

RecName:		Full=Stress response kinase A;
		EC 2.7.11.1;
AltName:		Full=Serine/threonine-protein kinase SrkA;

Gene name

srkA

Comments [?]

Function	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.
Catalytic activity	RHEA:17989: ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] EC 2.7.11.1
	RHEA:46608: ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] EC 2.7.11.1
Cofactor	Mg(2+)
Subunit	Monomer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the SrkA/RdoA protein kinase family.

Keywords [?]

ATP-binding
Cytoplasm
Kinase
Magnesium
Metal-binding
Nucleotide-binding
Phosphoprotein
Serine/threonine-protein kinase
Stress response
Transferase

Gene Ontology [?]

GO:0004674; Molecular function: protein serine/threonine kinase activity.
GO:0005524; Molecular function: ATP binding.
GO:0000287; Molecular function: magnesium ion binding.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF01636; APH; 1;

Features [?]

From: SRKA_ECOLI (P0C0K3)

Key From To Description Tag Condition FTGroup

ACT_SITE 201 201 Proton acceptor D

ACT_SITE 217 217 D

BINDING 206 206 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 N

BINDING 217 217 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 D

SITE 36 36 ATP S

Additional information [?]

Size range	280-416 amino acids
Related rules	None
Fusion	None

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