HAMAP rule MF_01499
General rule information
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Accession | MF_01499 |
Dates | 11-MAR-2016 (Created) 1-JUN-2023 (Last updated, Version 8) |
Name | DacA |
Scope | Bacteria |
Templates | Q8Y5E4 (DACA_LISMO); Q45589 (CDAA_BACSU): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. |
Catalytic activity | RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
EC 2.7.7.85 |
Subunit | Probably a homodimer. |
case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1>
Subcellular location | Cell membrane; Single-pass membrane protein. |
else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1>
Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> and <Feature:Transmembrane==1>
Subcellular location | Cell inner membrane; Single-pass membrane protein. |
else case <Property:Membrane=2> and <Feature:Transmembrane>1>
Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity | Belongs to the adenylate cyclase family. DacA/CdaA subfamily. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Cell membrane
Membrane
Nucleotide-binding
Nucleotidyltransferase
Transferase
Transmembrane
Transmembrane helix
Membrane
Nucleotide-binding
Nucleotidyltransferase
Transferase
Transmembrane
Transmembrane helix
Gene Ontology
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GO:0004016; Molecular function: adenylate cyclase activity.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0019932; Biological process: second-messenger-mediated signaling.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0019932; Biological process: second-messenger-mediated signaling.
Cross-references
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PROSITE | PS51794; DAC; 1; trigger=PRU01130; |
Pfam | PF02457; DisA_N; 1; |
NCBIfam | TIGR00159; TIGR00159; 1; |
PIRSF | PIRSF004793; UCP004793; 1; |
Computed features
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General | Transmembrane; -; 1-3; trigger=yes; |
Additional information
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Size range | 200-386 amino acids |
Related rules | MF_00838 (DACB); MF_00840 (DACZ); MF_01438 (DISA) |
Fusion | None |
Comments | Not found in all bacterial lineages. A few proteins also have the YbbR domain that may be associated with a DAC stimulatory activity. |