 |
|
Annotation rule MF_01499 |
General rule information
[?]
Accession |
MF_01499 |
Dates |
11-MAR-2016 (Created) 19-NOV-2019 (Last updated, Version 7) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
Protein name |
RecName:
|
Full=Diadenylate cyclase;
|
|
Short=DAC;
|
|
EC 2.7.7.85;
|
AltName:
|
Full=Cyclic-di-AMP synthase;
|
|
Short=c-di-AMP synthase;
|
|
Function |
Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. |
Catalytic activity |
RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
EC 2.7.7.85
|
Subunit |
Probably a homodimer. |
case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1>
Subcellular location |
Cell membrane; Single-pass membrane protein. |
else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1>
Subcellular location |
Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> and <Feature:Transmembrane==1>
Subcellular location |
Cell inner membrane; Single-pass membrane protein. |
else case <Property:Membrane=2> and <Feature:Transmembrane>1>
Subcellular location |
Cell inner membrane; Multi-pass membrane protein. |
end case
Similarity |
Belongs to the adenylate cyclase family. DacA/CdaA subfamily. |
case defined <Property:Membrane> and <Property:Membrane=2>
end case
GO:0004016; Molecular function: adenylate cyclase activity.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0019932; Biological process: second-messenger-mediated signaling.
General |
Transmembrane; -; 1-3; trigger=yes; |
Additional information
[?]
Size range |
200-386 amino acids |
Related rules |
MF_00838 (DACB); MF_00840 (DACZ); MF_01438 (DISA) |
Fusion |
None |
Comments |
Not found in all bacterial lineages. A few proteins also have the YbbR domain that may be associated with a DAC stimulatory activity. |