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HAMAP rule MF_01499

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General rule information [?]

Accession MF_01499
Dates 11-MAR-2016 (Created)
1-MAR-2024 (Last updated, Version 9)
Name DacA
Scope(s) Bacteria
Template(s) Q8Y5E4 (DACA_LISMO); Q45589 (CDAA_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01499 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DACA
Protein name RecName: Full=Diadenylate cyclase;
                 Short=DAC;
                 EC=2.7.7.85;
AltName: Full=Cyclic-di-AMP synthase;
                 Short=c-di-AMP synthase;
Gene name Name=dacA;

Comments [?]

FUNCTIONCatalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
CATALYTIC ACTIVITY Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85;
SUBUNITProbably a homodimer.
case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1>
SUBCELLULAR LOCATIONCell membrane; Single-pass membrane protein.
else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2> and <Feature:Transmembrane==1>
SUBCELLULAR LOCATIONCell inner membrane; Single-pass membrane protein.
else case <Property:Membrane=2> and <Feature:Transmembrane>1>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the adenylate cyclase family. DacA/CdaA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0004016; Molecular function:adenylate cyclase activity
GO:0005524; Molecular function:ATP binding
GO:0016779; Molecular function:nucleotidyltransferase activity

Cross-references [?]

PROSITE PS51794; DAC; 1;
Pfam PF02457; DisA_N; 1;
NCBIfam TIGR00159; TIGR00159; 1;
PIRSF PIRSF004793; UCP004793; 1;
General Transmembrane; -; 1-3;

Features [?]


Additional information [?]

Size range 200-386 amino acids
Related rules MF_00838
MF_00840
MF_01438
Fusion Nter: None Cter: None
Comments Not found in all bacterial lineages. A few proteins also have the YbbR domain that may be associated with a DAC stimulatory activity.



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