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HAMAP rule MF_01499

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General rule information [?]

Accession MF_01499
Dates 11-MAR-2016 (Created)
1-JUN-2023 (Last updated, Version 8)
Name DacA
Scope
Bacteria
Templates Q8Y5E4 (DACA_LISMO); Q45589 (CDAA_BACSU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DACA
Protein name
RecName: Full=Diadenylate cyclase;
Short=DAC;
EC 2.7.7.85;
AltName: Full=Cyclic-di-AMP synthase;
Short=c-di-AMP synthase;
Gene name
dacA

Comments [?]

Function Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.
Catalytic activity RHEA:35655: 2 ATP = 3',3'-c-di-AMP + 2 diphosphate
EC 2.7.7.85
Subunit Probably a homodimer.
case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1>
Subcellular location Cell membrane; Single-pass membrane protein.
else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2> and <Feature:Transmembrane==1>
Subcellular location Cell inner membrane; Single-pass membrane protein.
else case <Property:Membrane=2> and <Feature:Transmembrane>1>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the adenylate cyclase family. DacA/CdaA subfamily.

Keywords [?]

ATP-binding
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Cell membrane
Membrane
Nucleotide-binding
Nucleotidyltransferase
Transferase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0004016; Molecular function: adenylate cyclase activity.
GO:0005524; Molecular function: ATP binding.
GO:0016779; Molecular function: nucleotidyltransferase activity.
GO:0019932; Biological process: second-messenger-mediated signaling.

Cross-references [?]

PROSITE PS51794; DAC; 1; trigger=PRU01130;
Pfam PF02457; DisA_N; 1;
NCBIfam TIGR00159; TIGR00159; 1;
PIRSF PIRSF004793; UCP004793; 1;

Computed features [?]

General Transmembrane; -; 1-3; trigger=yes;

Additional information [?]

Size range 200-386 amino acids
Related rules MF_00838 (DACB); MF_00840 (DACZ); MF_01438 (DISA)
Fusion None
Comments Not found in all bacterial lineages. A few proteins also have the YbbR domain that may be associated with a DAC stimulatory activity.


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