HAMAP rule MF_01499
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01499 |
| Accession | MF_01499 |
| Dates | 11-MAR-2016 (Created)
1-MAR-2024 (Last updated, Version 9) |
| Name | DacA |
| Scope(s) |
Bacteria |
| Template(s) | Q8Y5E4 (DACA_LISMO); Q45589 (CDAA_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01499 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DACA |
| Protein name | RecName: Full=Diadenylate cyclase; Short=DAC; EC=2.7.7.85; AltName: Full=Cyclic-di-AMP synthase; Short=c-di-AMP synthase; |
| Gene name | Name=dacA; |
Comments
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| FUNCTION | Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. |
| CATALYTIC ACTIVITY | Reaction=2 ATP = 3',3'-c-di-AMP + 2 diphosphate; Xref=Rhea:RHEA:35655, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:71500; EC=2.7.7.85; |
| SUBUNIT | Probably a homodimer. |
| case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane==1> | |
| SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
| else case (not defined <Property:Membrane> or <Property:Membrane=1>) and <Feature:Transmembrane>1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> and <Feature:Transmembrane==1> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Single-pass membrane protein. |
| else case <Property:Membrane=2> and <Feature:Transmembrane>1> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the adenylate cyclase family. DacA/CdaA subfamily. |
Keywords
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| ATP-binding | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Cell membrane | |
| Membrane | |
| Nucleotide-binding | |
| Nucleotidyltransferase | |
| Transferase | |
| Transmembrane | |
| Transmembrane helix | |
Gene Ontology
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| GO:0004016; Molecular function:adenylate cyclase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0016779; Molecular function:nucleotidyltransferase activity |
Cross-references
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| PROSITE | PS51794; DAC; 1; |
| Pfam | PF02457; DisA_N; 1; |
| NCBIfam | TIGR00159; TIGR00159; 1; |
| PIRSF | PIRSF004793; UCP004793; 1; |
| General | Transmembrane; -; 1-3; |
Features
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Additional information
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| Size range | 200-386 amino acids |
| Related rules |
MF_00838 MF_00840 MF_01438 |
| Fusion | Nter: None Cter: None |
| Comments | Not found in all bacterial lineages. A few proteins also have the YbbR domain that may be associated with a DAC stimulatory activity. |