HAMAP rule MF_01500
General rule information
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Accession | MF_01500 |
Dates | 4-DEC-2003 (Created)
15-APR-2024 (Last updated, Version 28) |
Name | MtrG |
Scope(s) |
Archaea |
Template(s) | Q50774 (MTRG_METTM); [ Recover all ] |
Triggered by |
HAMAP; MF_01500 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | MTRG |
Protein name | RecName: Full=Tetrahydromethanopterin S-methyltransferase subunit G; EC=7.2.1.4; AltName: Full=N5-methyltetrahydromethanopterin--coenzyme M methyltransferase subunit G; |
Gene name | Name=mtrG; |
Comments
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FUNCTION | Part of a complex that catalyzes the formation of methyl- coenzyme M and tetrahydromethanopterin from coenzyme M and methyl- tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. |
CATALYTIC ACTIVITY | Reaction=5-methyl-5,6,7,8-tetrahydromethanopterin + coenzyme M + 2 Na(+)(in) = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M + 2 Na(+)(out); Xref=Rhea:RHEA:53492, ChEBI:CHEBI:29101, ChEBI:CHEBI:58103, ChEBI:CHEBI:58116, ChEBI:CHEBI:58286, ChEBI:CHEBI:58319; EC=7.2.1.4; |
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
PATHWAY | One-carbon metabolism; methanogenesis from CO(2); methyl- coenzyme M from 5,10-methylene-5,6,7,8-tetrahydromethanopterin: step 2/2. |
end case | |
SUBUNIT | The complex is composed of 8 subunits; MtrA, MtrB, MtrC, MtrD, MtrE, MtrF, MtrG and MtrH. |
SUBCELLULAR LOCATION | Cell membrane; Single-pass membrane protein. |
SIMILARITY | Belongs to the MtrG family. |
Keywords
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
Methanogenesis | |
end case | |
One-carbon metabolism | |
Transferase | |
<a href="https://www.uniprot.org/keywords/KW-1278">Translocase</a> | |
Methyltransferase | |
Cell membrane | |
Membrane | |
Transmembrane | |
Transmembrane helix |
Gene Ontology
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GO:0030269; Molecular function:tetrahydromethanopterin S-methyltransferase activity | |
GO:0006730; Biological process:one-carbon metabolic process | |
case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
GO:0019386; Biological process:methanogenesis, from carbon dioxide | |
end case | |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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Pfam | PF04210; MtrG; 1; |
NCBIfam | TIGR01149; MtrG; 1; |
General | Transmembrane; -; 1; |
Features
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Additional information
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Size range | 72-86 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |