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HAMAP rule MF_01512

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General rule information [?]

Accession MF_01512
Dates 29-MAR-2004 (Created)
19-NOV-2022 (Last updated, Version 21)
Name FosB
Scope(s) Bacteria
Template(s) O31817 (FOSB_BACSU); Q03377 (FOSB_STAEP); Q56415 (FOSA_SERMA); [ Recover all ]
Triggered by HAMAP; MF_01512 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FOSB
Protein name RecName: Full=Metallothiol transferase FosB;
AltName: Full=Fosfomycin resistance protein;
Gene name Name=fosB;

Comments [?]

FUNCTIONMetallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.
case <FTGroup:1>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
end case
SIMILARITYBelongs to the fosfomycin resistance protein family. FosB subfamily.

Keywords [?]

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function:magnesium ion binding
end case
GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0046677; Biological process:response to antibiotic
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00903; Glyoxalase; 1;
PROSITE PS51819; VOC; 1;

Features [?]

From: FOSB_BACSU (O31817)
Key From To Description Tag Condition FTGroup
BINDING 8 8 /ligand="Mg(2+)"
H 1
BINDING 67 67 /ligand="Mg(2+)"
H 1
BINDING 116 116 /ligand="Mg(2+)"
E 1

Additional information [?]

Size range 138-154 amino acids
Related rules None
Fusion Nter: None Cter: None

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