HAMAP rule MF_01512

General rule information [?]

Accession	MF_01512
Dates	29-MAR-2004 (Created) 19-NOV-2022 (Last updated, Version 21)

Name

FosB

Scope

Bacteria; Bacillales

Templates

O31817 (FOSB_BACSU); Q03377 (FOSB_STAEP); Q56415 (FOSA_SERMA): [Recover all]

Triggered by

HAMAP; MF_01512 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FOSB

Protein name

RecName:		Full=Metallothiol transferase FosB;
		EC 2.5.1.-;
AltName:		Full=Fosfomycin resistance protein;

Gene name

fosB

Comments [?]

Function

Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.

case <FTGroup:1>

Cofactor

Mg(2+)

end case

Subunit	Homodimer.
Subcellular location	Cytoplasm.
Similarity	Belongs to the fosfomycin resistance protein family. FosB subfamily.

Keywords [?]

Cytoplasm
Transferase

case <FTGroup:1>

Magnesium
Metal-binding

end case

Antibiotic resistance

Gene Ontology [?]

case <FTGroup:1>

GO:0000287; Molecular function: magnesium ion binding.

end case

GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0046677; Biological process: response to antibiotic.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam	PF00903; Glyoxalase; 1;
PROSITE	PS51819; VOC; 1; trigger=PRU01163;

Features [?]

From: FOSB_BACSU (O31817)

Key From To Description Tag Condition FTGroup

BINDING 8 8 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 H 1

BINDING 67 67 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 H 1

BINDING 116 116 /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 E 1

Additional information [?]

Size range	138-154 amino acids
Related rules	None
Fusion	None

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