HAMAP rule MF_01512
General rule information
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Accession | MF_01512 |
Dates | 29-MAR-2004 (Created) 19-NOV-2022 (Last updated, Version 21) |
Name | FosB |
Scope | Bacteria; Bacillales |
Templates | O31817 (FOSB_BACSU); Q03377 (FOSB_STAEP); Q56415 (FOSA_SERMA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. |
case <FTGroup:1>
Cofactor | Mg(2+) |
end case
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the fosfomycin resistance protein family. FosB subfamily. |
Keywords
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case <FTGroup:1>
end case
Gene Ontology
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case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0046677; Biological process: response to antibiotic.
GO:0005737; Cellular component: cytoplasm.
GO:0046677; Biological process: response to antibiotic.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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Features
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From: FOSB_BACSU (O31817) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 8 | 8 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | H | 1 | |||||||
BINDING | 67 | 67 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | H | 1 | |||||||
BINDING | 116 | 116 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420 | E | 1 |
Additional information
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Size range | 138-154 amino acids |
Related rules | None |
Fusion | None |