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HAMAP rule MF_01512

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General rule information [?]

Accession MF_01512
Dates 29-MAR-2004 (Created)
19-NOV-2022 (Last updated, Version 21)
Name FosB
Bacteria; Bacillales
Templates O31817 (FOSB_BACSU); Q03377 (FOSB_STAEP); Q56415 (FOSA_SERMA): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Metallothiol transferase FosB;
EC 2.5.1.-;
AltName: Full=Fosfomycin resistance protein;
Gene name

Comments [?]

Function Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.
case <FTGroup:1>
Cofactor Mg(2+)
end case
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the fosfomycin resistance protein family. FosB subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0046677; Biological process: response to antibiotic.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00903; Glyoxalase; 1;
PROSITE PS51819; VOC; 1; trigger=PRU01163;

Features [?]

From: FOSB_BACSU (O31817)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     8     8       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     H   1
BINDING     67     67       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     H   1
BINDING     116     116       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420     E   1

Additional information [?]

Size range 138-154 amino acids
Related rules None
Fusion None