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Annotation rule MF_01512
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General rule information [?]

Accession MF_01512
Dates 29-MAR-2004 (Created)
19-NOV-2019 (Last updated, Version 19)
Name FosB
Scope
Bacteria; Bacillales
Templates O31817 (FOSB_BACSU); Q03377 (FOSB_STAEP); Q56415 (FOSA_SERMA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FOSB
Protein name
RecName: Full=Metallothiol transferase FosB;
EC 2.5.1.-;
AltName: Full=Fosfomycin resistance protein;
Gene name
fosB

Comments [?]

Function Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor.
case <FTGroup:1>
Cofactor Mg(2+)
end case
Subunit Homodimer.
Subcellular location Cytoplasm.
Similarity Belongs to the fosfomycin resistance protein family. FosB subfamily.

Keywords [?]

case <FTGroup:1>
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0000287; Molecular function: magnesium ion binding.
end case
GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0046677; Biological process: response to antibiotic.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF00903; Glyoxalase; 1;
PROSITE PS51819; VOC; 1; trigger=PRU01163;

Features [?]

From: FOSB_BACSU (O31817)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     8     8       Magnesium     H   1
METAL     67     67       Magnesium     H   1
METAL     116     116       Magnesium     E   1

Additional information [?]

Size range 138-154 amino acids
Related rules None
Fusion None