HAMAP rule MF_01512
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01512 |
| Accession | MF_01512 |
| Dates | 28-FEB-2005 (Created)
19-NOV-2022 (Last updated, Version 19) |
| Name | FosB |
| Scope(s) |
Bacteria Bacillales |
| Template(s) | O31817; Q03377; Q56415; [ Recover all ] |
| Triggered by |
HAMAP; MF_01512 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FOSB |
| Protein name | RecName: Full=Metallothiol transferase FosB; EC=2.5.1.-; AltName: Full=Fosfomycin resistance protein; |
| Gene name | Name=fosB; |
Comments
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| FUNCTION | Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor. |
| case <FTGroup:1> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; |
| end case | |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the fosfomycin resistance protein family. FosB subfamily. |
Keywords
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| Cytoplasm | |
| Transferase | |
| case <FTGroup:1> | |
| Magnesium | |
| Metal-binding | |
| end case | |
| Antibiotic resistance | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| end case | |
| GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups | |
| GO:0046677; Biological process:response to antibiotic | |
| GO:0005737; Cellular component:cytoplasm | |
Cross-references
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Features
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| From: FOSB_BACSU (O31817) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 8 | 8 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
H | 1 | |||||||
| BINDING | 67 | 67 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
H | 1 | |||||||
| BINDING | 116 | 116 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" |
E | 1 | |||||||
Additional information
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| Size range | 138-154 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |