HAMAP rule MF_01516

General rule information [?]

Accession	MF_01516
Dates	25-MAY-2004 (Created) 19-NOV-2022 (Last updated, Version 18)

Name	Malate_dehydrog_1

Scope

Bacteria; Gammaproteobacteria

Templates

P61889 (MDH_ECOLI); Q7X3X5 (MDH_MORS2); P48364 (MDH_MORS5): [Recover all]

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MDH

Protein name

RecName:		Full=Malate dehydrogenase;
		EC 1.1.1.37;

Gene name

mdh

Comments [?]

Function	Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity	RHEA:21432: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate EC 1.1.1.37
Subunit	Homodimer.
Similarity	Belongs to the LDH/MDH superfamily. MDH type 1 family.

Keywords [?]

Gene Ontology [?]

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

Features [?]

From: MDH_ECOLI (P61889)

Key From To Description Tag Condition FTGroup

BINDING 7 13 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 G-A-[AS]-G-G-I-G

BINDING 117 119 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 [IV]-T-N

ACT_SITE 177 177 Proton acceptor H

BINDING 34 34 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 D

BINDING 81 81 /ligand="substrate R

BINDING 87 87 /ligand="substrate R

BINDING 94 94 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 N

BINDING 119 119 /ligand="substrate N

BINDING 153 153 /ligand="substrate R

BINDING 227 227 /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 M

Additional information [?]