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HAMAP rule MF_01516

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General rule information [?]

Accession MF_01516
Dates 25-MAY-2004 (Created)
19-NOV-2022 (Last updated, Version 18)
Name Malate_dehydrog_1
Bacteria; Gammaproteobacteria
Templates P61889 (MDH_ECOLI); Q7X3X5 (MDH_MORS2); P48364 (MDH_MORS5): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Malate dehydrogenase;
Gene name

Comments [?]

Function Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity RHEA:21432: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
Subunit Homodimer.
Similarity Belongs to the LDH/MDH superfamily. MDH type 1 family.

Keywords [?]

Gene Ontology [?]

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

Pfam PF02866; Ldh_1_C; 1;
PF00056; Ldh_1_N; 1;
TIGRFAMs TIGR01772; MDH_euk_gproteo; 1;
PROSITE PS00068; MDH; 1;

Features [?]

From: MDH_ECOLI (P61889)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     7     13       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     G-A-[AS]-G-G-I-G  
BINDING     117     119       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [IV]-T-N  
ACT_SITE     177     177       Proton acceptor     H  
BINDING     34     34       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     D  
BINDING     81     81       /ligand="substrate     R  
BINDING     87     87       /ligand="substrate     R  
BINDING     94     94       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     N  
BINDING     119     119       /ligand="substrate     N  
BINDING     153     153       /ligand="substrate     R  
BINDING     227     227       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     M  

Additional information [?]

Size range 310-324 amino acids
Related rules MF_00487 (MDH); MF_00488 (LDH); MF_01517 (MDH)
Fusion None