HAMAP rule MF_01516
General rule information
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| Accession | MF_01516 |
| Dates | 25-MAY-2004 (Created)
3-SEP-2024 (Last updated, Version 20) |
| Name | Malate_dehydrog_1 |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P61889 (MDH_ECOLI); Q7X3X5 (MDH_MORS2); P48364 (MDH_MORS5); [ Recover all ] |
| Triggered by |
HAMAP; MF_01516 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MDH |
| Protein name | RecName: Full=Malate dehydrogenase; EC=1.1.1.37; |
| Gene name | Name=mdh; |
Comments
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| FUNCTION | Catalyzes the reversible oxidation of malate to oxaloacetate. |
| CATALYTIC ACTIVITY | Reaction=(S)-malate + NAD(+) = oxaloacetate + NADH + H(+); Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the LDH/MDH superfamily. MDH type 1 family. |
Keywords
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Gene Ontology
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| GO:0030060; Molecular function:L-malate dehydrogenase (NAD+) activity |
| GO:0006099; Biological process:tricarboxylic acid cycle |
Cross-references
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| Pfam | PF02866; Ldh_1_C; 1; |
| Pfam | PF00056; Ldh_1_N; 1; |
| NCBIfam | TIGR01772; MDH_euk_gproteo; 1; |
| PROSITE | PS00068; MDH; 1; |
Features
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| From: MDH_ECOLI (P61889) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 7 | 13 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-A-[AS]-G-G-I-G | ||||||||
| BINDING | 117 | 119 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[IV]-T-N | ||||||||
| ACT_SITE | 177 | 177 | /note="Proton acceptor" | H | ||||||||
| BINDING | 34 | 34 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
D | ||||||||
| BINDING | 81 | 81 | /ligand="substrate" | R | ||||||||
| BINDING | 87 | 87 | /ligand="substrate" | R | ||||||||
| BINDING | 94 | 94 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
| BINDING | 119 | 119 | /ligand="substrate" | N | ||||||||
| BINDING | 153 | 153 | /ligand="substrate" | R | ||||||||
| BINDING | 227 | 227 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
M | ||||||||
Additional information
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| Size range | 310-324 amino acids |
| Related rules |
MF_00487 MF_00488 MF_01517 |
| Fusion | Nter: None Cter: None |