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HAMAP rule MF_01516

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General rule information [?]

Accession MF_01516
Dates 25-MAY-2004 (Created)
1-JUN-2023 (Last updated, Version 19)
Name Malate_dehydrog_1
Scope(s) Bacteria
Template(s) P61889 (MDH_ECOLI); Q7X3X5 (MDH_MORS2); P48364 (MDH_MORS5); [ Recover all ]
Triggered by HAMAP; MF_01516 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDH
Protein name RecName: Full=Malate dehydrogenase;
Gene name Name=mdh;

Comments [?]

FUNCTIONCatalyzes the reversible oxidation of malate to oxaloacetate.
CATALYTIC ACTIVITY Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SIMILARITYBelongs to the LDH/MDH superfamily. MDH type 1 family.

Keywords [?]

Gene Ontology [?]

GO:0030060; Molecular function:L-malate dehydrogenase activity
GO:0006099; Biological process:tricarboxylic acid cycle

Cross-references [?]

Pfam PF02866; Ldh_1_C; 1;
Pfam PF00056; Ldh_1_N; 1;
NCBIfam TIGR01772; MDH_euk_gproteo; 1;
PROSITE PS00068; MDH; 1;

Features [?]

From: MDH_ECOLI (P61889)
Key From To Description Tag Condition FTGroup
BINDING 7 13 /ligand="NAD(+)"
BINDING 117 119 /ligand="NAD(+)"
ACT_SITE 177 177 /note="Proton acceptor" H
BINDING 34 34 /ligand="NAD(+)"
BINDING 81 81 /ligand="substrate" R
BINDING 87 87 /ligand="substrate" R
BINDING 94 94 /ligand="NAD(+)"
BINDING 119 119 /ligand="substrate" N
BINDING 153 153 /ligand="substrate" R
BINDING 227 227 /ligand="NAD(+)"

Additional information [?]

Size range 310-324 amino acids
Related rules MF_00487
Fusion Nter: None Cter: None

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