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HAMAP rule MF_01517

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General rule information [?]

Accession MF_01517
Dates 27-MAY-2004 (Created)
1-JUN-2023 (Last updated, Version 25)
Name Malate_dehydrog_2
Scope(s) Bacteria
Template(s) P10584 (MDH_THETH); Q8NN33 (MDH_CORGL); Q82HS2 (MDH_STRAW); Q9K3J3 (MDH_STRCO); [ Recover all ]
Triggered by HAMAP; MF_01517 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDH
Protein name RecName: Full=Malate dehydrogenase;
Gene name Name=mdh;

Comments [?]

FUNCTIONCatalyzes the reversible oxidation of malate to oxaloacetate.
CATALYTIC ACTIVITY Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
SIMILARITYBelongs to the LDH/MDH superfamily. MDH type 2 family.

Keywords [?]

Gene Ontology [?]

GO:0030060; Molecular function:L-malate dehydrogenase activity
GO:0006099; Biological process:tricarboxylic acid cycle

Cross-references [?]

Pfam PF02866; Ldh_1_C; 1;
Pfam PF00056; Ldh_1_N; 1;
NCBIfam TIGR01759; MalateDH-SF1; 1;
PROSITE PS00068; MDH; 1;

Features [?]

From: MDH_THETH (P10584)
Key From To Description Tag Condition FTGroup
BINDING 11 17 /ligand="NAD(+)"
BINDING 129 131 /ligand="NAD(+)"
ACT_SITE 187 187 /note="Proton acceptor" H
BINDING 92 92 /ligand="substrate" R
BINDING 98 98 /ligand="substrate" R
BINDING 105 105 /ligand="NAD(+)"
BINDING 112 112 /ligand="NAD(+)"
BINDING 131 131 /ligand="substrate" N
BINDING 162 162 /ligand="substrate" R

Additional information [?]

Size range 310-375 amino acids
Related rules MF_00487
Fusion Nter: None Cter: None

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