HAMAP rule MF_01517
General rule information
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| Accession | MF_01517 |
| Dates | 27-MAY-2004 (Created)
1-JUN-2023 (Last updated, Version 25) |
| Name | Malate_dehydrog_2 |
| Scope(s) |
Bacteria |
| Template(s) | P10584 (MDH_THETH); Q8NN33 (MDH_CORGL); Q82HS2 (MDH_STRAW); Q9K3J3 (MDH_STRCO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01517 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MDH |
| Protein name | RecName: Full=Malate dehydrogenase; EC=1.1.1.37; |
| Gene name | Name=mdh; |
Comments
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| FUNCTION | Catalyzes the reversible oxidation of malate to oxaloacetate. |
| CATALYTIC ACTIVITY | Reaction=(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate; Xref=Rhea:RHEA:21432, ChEBI:CHEBI:15378, ChEBI:CHEBI:15589, ChEBI:CHEBI:16452, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.37; |
| SIMILARITY | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Keywords
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Gene Ontology
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| GO:0030060; Molecular function:L-malate dehydrogenase activity |
| GO:0006099; Biological process:tricarboxylic acid cycle |
Cross-references
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| Pfam | PF02866; Ldh_1_C; 1; |
| Pfam | PF00056; Ldh_1_N; 1; |
| NCBIfam | TIGR01759; MalateDH-SF1; 1; |
| PROSITE | PS00068; MDH; 1; |
Features
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| From: MDH_THETH (P10584) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 11 | 17 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
G-[AG]-x-G-x-[IV]-[GACS] | ||||||||
| BINDING | 129 | 131 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
[VT]-G-N | ||||||||
| ACT_SITE | 187 | 187 | /note="Proton acceptor" | H | ||||||||
| BINDING | 92 | 92 | /ligand="substrate" | R | ||||||||
| BINDING | 98 | 98 | /ligand="substrate" | R | ||||||||
| BINDING | 105 | 105 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
N | ||||||||
| BINDING | 112 | 112 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540" |
Q | ||||||||
| BINDING | 131 | 131 | /ligand="substrate" | N | ||||||||
| BINDING | 162 | 162 | /ligand="substrate" | R | ||||||||
Additional information
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| Size range | 310-375 amino acids |
| Related rules |
MF_00487 MF_00488 MF_01516 |
| Fusion | Nter: None Cter: None |