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Annotation rule MF_01517
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General rule information [?]

Accession MF_01517
Dates 27-MAY-2004 (Created)
19-NOV-2019 (Last updated, Version 22)
Name Malate_dehydrog_2
Templates P10584 (MDH_THETH); Q8NN33 (MDH_CORGL); Q82HS2 (MDH_STRAW); Q9K3J3 (MDH_STRCO): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Malate dehydrogenase;
Gene name

Comments [?]

Function Catalyzes the reversible oxidation of malate to oxaloacetate.
Catalytic activity RHEA:21432: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
Similarity Belongs to the LDH/MDH superfamily. MDH type 2 family.

Keywords [?]

Gene Ontology [?]

GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.

Cross-references [?]

Pfam PF02866; Ldh_1_C; 1;
PF00056; Ldh_1_N; 1;
TIGRFAMs TIGR01759; MalateDH-SF1; 1;
PROSITE PS00068; MDH; 1;

Features [?]

From: MDH_THETH (P10584)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     11     17       NAD     G-[AG]-x-G-x-[IV]-[GACS]  
NP_BIND     129     131       NAD     [VT]-G-N  
ACT_SITE     187     187       Proton acceptor     H  
BINDING     92     92       Substrate     R  
BINDING     98     98       Substrate     R  
BINDING     105     105       NAD     N  
BINDING     112     112       NAD     Q  
BINDING     131     131       Substrate     N  
BINDING     162     162       Substrate     R  

Additional information [?]

Size range 310-375 amino acids
Related rules MF_00487 (MDH); MF_00488 (LDH); MF_01516 (MDH)
Fusion None