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| Annotation rule MF_01517 |
General rule information
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| Accession | MF_01517 |
| Dates | 27-MAY-2004 (Created) 19-NOV-2019 (Last updated, Version 22) |
| Name | Malate_dehydrog_2 |
| Scope | Bacteria |
| Templates | P10584 (MDH_THETH); Q8NN33 (MDH_CORGL); Q82HS2 (MDH_STRAW); Q9K3J3 (MDH_STRCO): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the reversible oxidation of malate to oxaloacetate. |
| Catalytic activity | RHEA:21432: (S)-malate + NAD(+) = H(+) + NADH + oxaloacetate
EC 1.1.1.37 |
| Similarity | Belongs to the LDH/MDH superfamily. MDH type 2 family. |
Keywords
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Gene Ontology
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GO:0030060; Molecular function: L-malate dehydrogenase activity.
GO:0006099; Biological process: tricarboxylic acid cycle.
GO:0006099; Biological process: tricarboxylic acid cycle.
Cross-references
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| Pfam | PF02866; Ldh_1_C; 1; |
| PF00056; Ldh_1_N; 1; | |
| TIGRFAMs | TIGR01759; MalateDH-SF1; 1; |
| PROSITE | PS00068; MDH; 1; |
Features
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| From: MDH_THETH (P10584) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| NP_BIND | 11 | 17 | NAD | G-[AG]-x-G-x-[IV]-[GACS] | ||||||||
| NP_BIND | 129 | 131 | NAD | [VT]-G-N | ||||||||
| ACT_SITE | 187 | 187 | Proton acceptor | H | ||||||||
| BINDING | 92 | 92 | Substrate | R | ||||||||
| BINDING | 98 | 98 | Substrate | R | ||||||||
| BINDING | 105 | 105 | NAD | N | ||||||||
| BINDING | 112 | 112 | NAD | Q | ||||||||
| BINDING | 131 | 131 | Substrate | N | ||||||||
| BINDING | 162 | 162 | Substrate | R | ||||||||
Additional information
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| Size range | 310-375 amino acids |
| Related rules | MF_00487 (MDH); MF_00488 (LDH); MF_01516 (MDH) |
| Fusion | None |