Home  |  Contact
Annotation rule MF_01524
Send feedback

General rule information [?]

Accession MF_01524
Dates 23-NOV-2004 (Created)
19-NOV-2019 (Last updated, Version 15)
Name CaiC
Scope
Bacteria; Enterobacterales
Template P31552 (CAIC_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
CAIC
Protein name
RecName: Full=Crotonobetaine/carnitine--CoA ligase;
EC 6.2.1.48;
Gene name
caiC

Comments [?]

Function Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
Catalytic activity RHEA:28514: (R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate
EC 6.2.1.48
RHEA:30079: ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate
RHEA:55960: 4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA
Pathway Amine and polyamine metabolism; carnitine metabolism.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords [?]


Gene Ontology [?]

GO:0016405; Molecular function: CoA-ligase activity.

Cross-references [?]

Pfam PF00501; AMP-binding; 1;
PRINTS PR00154; AMPBINDING; 1;
PROSITE PS00455; AMP_BINDING; 1;

Additional information [?]

Size range 510-518 amino acids
Related rules None
Fusion None