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HAMAP rule MF_01524

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General rule information [?]

Accession MF_01524
Dates 23-NOV-2004 (Created)
12-MAR-2024 (Last updated, Version 17)
Name CaiC
Scope(s) Bacteria
Template(s) P31552 (CAIC_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01524 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CAIC
Protein name RecName: Full=Crotonobetaine/carnitine--CoA ligase;
Gene name Name=caiC;

Comments [?]

FUNCTIONCatalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
CATALYTIC ACTIVITY Reaction=(R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:28514, ChEBI:CHEBI:16347, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:60932, ChEBI:CHEBI:456215; EC=;
CATALYTIC ACTIVITY Reaction=ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate; Xref=Rhea:RHEA:30079, ChEBI:CHEBI:17237, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:60933, ChEBI:CHEBI:456215;
CATALYTIC ACTIVITY Reaction=4-(trimethylamino)butanoate + ATP + CoA = 4- (trimethylamino)butanoyl-CoA + AMP + diphosphate; Xref=Rhea:RHEA:55960, ChEBI:CHEBI:16244, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:61513, ChEBI:CHEBI:456215;
PATHWAYAmine and polyamine metabolism; carnitine metabolism.
SIMILARITYBelongs to the ATP-dependent AMP-binding enzyme family.

Keywords [?]

Gene Ontology [?]

GO:0016405; Molecular function:CoA-ligase activity
GO:0009437; Biological process:carnitine metabolic process

Cross-references [?]

Pfam PF00501; AMP-binding; 1;

Features [?]

Additional information [?]

Size range 510-518 amino acids
Related rules None
Fusion Nter: None Cter: None

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