HAMAP rule MF_01524

General rule information [?]

Accession	MF_01524
Dates	23-NOV-2004 (Created) 15-DEC-2022 (Last updated, Version 16)

Name

CaiC

Scope

Bacteria; Enterobacterales

Template

P31552 (CAIC_ECOLI)

Triggered by

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CAIC

Protein name

RecName:		Full=Crotonobetaine/carnitine--CoA ligase;
		EC 6.2.1.48;

Gene name

caiC

Comments [?]

Function	Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine.
Catalytic activity	RHEA:28514: (R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate EC 6.2.1.48
	RHEA:30079: ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate
	RHEA:55960: 4-(trimethylamino)butanoate + ATP + CoA = 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate
Pathway	Amine and polyamine metabolism; carnitine metabolism.
Similarity	Belongs to the ATP-dependent AMP-binding enzyme family.

Keywords [?]

Gene Ontology [?]

GO:0016405; Molecular function: CoA-ligase activity.

Cross-references [?]

Additional information [?]