HAMAP rule MF_01524
General rule information
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Accession |
MF_01524 |
Dates |
23-NOV-2004 (Created) 15-DEC-2022 (Last updated, Version 16) |
Scope |
Bacteria; Enterobacterales |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Crotonobetaine/carnitine--CoA ligase;
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EC 6.2.1.48;
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Function |
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. |
Catalytic activity |
RHEA:28514: (R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate
EC 6.2.1.48
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RHEA:30079: ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate
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RHEA:55960: 4-(trimethylamino)butanoate + ATP + CoA = 4-(trimethylamino)butanoyl-CoA + AMP + diphosphate
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Pathway |
Amine and polyamine metabolism; carnitine metabolism. |
Similarity |
Belongs to the ATP-dependent AMP-binding enzyme family. |
GO:0016405; Molecular function: CoA-ligase activity.
Additional information
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Size range |
510-518 amino acids |
Related rules |
None |
Fusion |
None |