Function |
Catalyzes the transfer of CoA to carnitine, generating the initial carnitinyl-CoA needed for the CaiB reaction cycle. Also has activity toward crotonobetaine and gamma-butyrobetaine. |
Catalytic activity |
RHEA:28514: (R)-carnitine + ATP + CoA = (R)-carnitinyl-CoA + AMP + diphosphate
EC 6.2.1.48
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RHEA:30079: ATP + CoA + crotonobetaine = AMP + crotonobetainyl-CoA + diphosphate
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RHEA:55960: 4-(trimethylamino)butanoate + ATP + CoA = AMP + diphosphate + gamma-butyrobetainyl-CoA
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Pathway |
Amine and polyamine metabolism; carnitine metabolism. |
Similarity |
Belongs to the ATP-dependent AMP-binding enzyme family. |