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| Annotation rule MF_01529 |
General rule information
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| Accession | MF_01529 |
| Dates | 14-FEB-2005 (Created) 19-NOV-2019 (Last updated, Version 26) |
| Name | MFS_MdtH |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P69367 (MDTH_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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case <OC:Escherichia>
| Function | Confers resistance to norfloxacin and enoxacin. |
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily. |
Keywords
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case <OC:Escherichia>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0022857; Molecular function: transmembrane transporter activity.
GO:0055085; Biological process: transmembrane transport.
GO:0005886; Cellular component: plasma membrane.
GO:0055085; Biological process: transmembrane transport.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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Computed features
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case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
| General | Transmembrane; -; 10-12; trigger=yes; |
end case
Features
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case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
| From: MDTH_ECOLI (P69367) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TOPO_DOM | Nter | 12 | Cytoplasmic | |||||||||
| TRANSMEM | 13 | 33 | Helical | |||||||||
| TOPO_DOM | 34 | 98 | Periplasmic | |||||||||
| TRANSMEM | 99 | 116 | Helical | |||||||||
| TOPO_DOM | 117 | 138 | Cytoplasmic | |||||||||
| TRANSMEM | 139 | 159 | Helical | |||||||||
| TOPO_DOM | 160 | 164 | Periplasmic | |||||||||
| TRANSMEM | 165 | 185 | Helical | |||||||||
| TOPO_DOM | 186 | 213 | Cytoplasmic | |||||||||
| TRANSMEM | 214 | 234 | Helical | |||||||||
| TOPO_DOM | 235 | 243 | Periplasmic | |||||||||
| TRANSMEM | 244 | 264 | Helical | |||||||||
| TOPO_DOM | 265 | 276 | Cytoplasmic | |||||||||
| TRANSMEM | 277 | 297 | Helical | |||||||||
| TOPO_DOM | 298 | 299 | Periplasmic | |||||||||
| TRANSMEM | 300 | 320 | Helical | |||||||||
| TOPO_DOM | 321 | 339 | Cytoplasmic | |||||||||
| TRANSMEM | 340 | 360 | Helical | |||||||||
| TOPO_DOM | 361 | 367 | Periplasmic | |||||||||
| TRANSMEM | 368 | 388 | Helical | |||||||||
| TOPO_DOM | 389 | Cter | Cytoplasmic | |||||||||
end case
Additional information
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| Size range | 397-411 amino acids |
| Related rules | None |
| Fusion | None |