HAMAP rule MF_01529
General rule information
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| Accession | MF_01529 |
| Dates | 14-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 26) |
| Name | MFS_MdtH |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P69367 (MDTH_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01529 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MDTH |
| Protein name | RecName: Full=Multidrug resistance protein MdtH; |
| Gene name | Name=mdtH; |
Comments
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| case <OC:Escherichia> | |
| FUNCTION | Confers resistance to norfloxacin and enoxacin. |
| end case | |
| case not defined <Property:Membrane> or <Property:Membrane=1> | |
| SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
| else case <Property:Membrane=2> | |
| SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
| end case | |
| SIMILARITY | Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily. |
Keywords
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| case <OC:Escherichia> | |
| Antibiotic resistance | |
| end case | |
| Cell membrane | |
| case defined <Property:Membrane> and <Property:Membrane=2> | |
| Cell inner membrane | |
| end case | |
| Membrane | |
| Transmembrane | |
| Transport | |
| Transmembrane helix | |
Gene Ontology
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| GO:0022857; Molecular function:transmembrane transporter activity |
| GO:0055085; Biological process:transmembrane transport |
| GO:0005886; Cellular component:plasma membrane |
Cross-references
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| Pfam | PF07690; MFS_1; 1; |
| PROSITE | PS50850; MFS; 1; |
| General | Transmembrane; -; 10-12; |
Features
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| From: MDTH_ECOLI (P69367) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella> | ||||||||||||
| TOPO_DOM | Nter | 12 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 13 | 33 | /note="Helical" | |||||||||
| TOPO_DOM | 34 | 98 | /note="Periplasmic" | |||||||||
| TRANSMEM | 99 | 116 | /note="Helical" | |||||||||
| TOPO_DOM | 117 | 138 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 139 | 159 | /note="Helical" | |||||||||
| TOPO_DOM | 160 | 164 | /note="Periplasmic" | |||||||||
| TRANSMEM | 165 | 185 | /note="Helical" | |||||||||
| TOPO_DOM | 186 | 213 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 214 | 234 | /note="Helical" | |||||||||
| TOPO_DOM | 235 | 243 | /note="Periplasmic" | |||||||||
| TRANSMEM | 244 | 264 | /note="Helical" | |||||||||
| TOPO_DOM | 265 | 276 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 277 | 297 | /note="Helical" | |||||||||
| TOPO_DOM | 298 | 299 | /note="Periplasmic" | |||||||||
| TRANSMEM | 300 | 320 | /note="Helical" | |||||||||
| TOPO_DOM | 321 | 339 | /note="Cytoplasmic" | |||||||||
| TRANSMEM | 340 | 360 | /note="Helical" | |||||||||
| TOPO_DOM | 361 | 367 | /note="Periplasmic" | |||||||||
| TRANSMEM | 368 | 388 | /note="Helical" | |||||||||
| TOPO_DOM | 389 | Cter | /note="Cytoplasmic" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 397-411 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |