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HAMAP rule MF_01529

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General rule information [?]

Accession MF_01529
Dates 14-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 26)
Name MFS_MdtH
Scope(s) Bacteria
Template(s) P69367 (MDTH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01529 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MDTH
Protein name RecName: Full=Multidrug resistance protein MdtH;
Gene name Name=mdtH;

Comments [?]

case <OC:Escherichia>
FUNCTIONConfers resistance to norfloxacin and enoxacin.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.

Keywords [?]

case <OC:Escherichia>
Antibiotic resistance
end case
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Transmembrane helix

Gene Ontology [?]

GO:0022857; Molecular function:transmembrane transporter activity
GO:0055085; Biological process:transmembrane transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Pfam PF07690; MFS_1; 1;
PROSITE PS50850; MFS; 1;
General Transmembrane; -; 10-12;

Features [?]

From: MDTH_ECOLI (P69367)
Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
TOPO_DOM Nter 12 /note="Cytoplasmic"
TRANSMEM 13 33 /note="Helical"
TOPO_DOM 34 98 /note="Periplasmic"
TRANSMEM 99 116 /note="Helical"
TOPO_DOM 117 138 /note="Cytoplasmic"
TRANSMEM 139 159 /note="Helical"
TOPO_DOM 160 164 /note="Periplasmic"
TRANSMEM 165 185 /note="Helical"
TOPO_DOM 186 213 /note="Cytoplasmic"
TRANSMEM 214 234 /note="Helical"
TOPO_DOM 235 243 /note="Periplasmic"
TRANSMEM 244 264 /note="Helical"
TOPO_DOM 265 276 /note="Cytoplasmic"
TRANSMEM 277 297 /note="Helical"
TOPO_DOM 298 299 /note="Periplasmic"
TRANSMEM 300 320 /note="Helical"
TOPO_DOM 321 339 /note="Cytoplasmic"
TRANSMEM 340 360 /note="Helical"
TOPO_DOM 361 367 /note="Periplasmic"
TRANSMEM 368 388 /note="Helical"
TOPO_DOM 389 Cter /note="Cytoplasmic"
end case

Additional information [?]

Size range 397-411 amino acids
Related rules None
Fusion Nter: None Cter: None

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