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Annotation rule MF_01529
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General rule information [?]

Accession MF_01529
Dates 14-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 26)
Name MFS_MdtH
Scope
Bacteria; Gammaproteobacteria
Template P69367 (MDTH_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MDTH
Protein name
RecName: Full=Multidrug resistance protein MdtH;
Gene name
mdtH

Comments [?]

case <OC:Escherichia>
Function Confers resistance to norfloxacin and enoxacin.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
Subcellular location Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
Subcellular location Cell inner membrane; Multi-pass membrane protein.
end case
Similarity Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily.

Keywords [?]

case <OC:Escherichia>
end case
case defined <Property:Membrane> and <Property:Membrane=2>
end case

Gene Ontology [?]

GO:0022857; Molecular function: transmembrane transporter activity.
GO:0055085; Biological process: transmembrane transport.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam PF07690; MFS_1; 1;
PROSITE PS50850; MFS; 1;

Computed features [?]

case not <OC:Escherichia> and not <OC:Shigella> and not <OC:Salmonella>
General Transmembrane; -; 10-12; trigger=yes;
end case

Features [?]

case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
From: MDTH_ECOLI (P69367)
Key     From     To       Description   Tag   Condition   FTGroup
TOPO_DOM     Nter     12       Cytoplasmic        
TRANSMEM     13     33       Helical        
TOPO_DOM     34     98       Periplasmic        
TRANSMEM     99     116       Helical        
TOPO_DOM     117     138       Cytoplasmic        
TRANSMEM     139     159       Helical        
TOPO_DOM     160     164       Periplasmic        
TRANSMEM     165     185       Helical        
TOPO_DOM     186     213       Cytoplasmic        
TRANSMEM     214     234       Helical        
TOPO_DOM     235     243       Periplasmic        
TRANSMEM     244     264       Helical        
TOPO_DOM     265     276       Cytoplasmic        
TRANSMEM     277     297       Helical        
TOPO_DOM     298     299       Periplasmic        
TRANSMEM     300     320       Helical        
TOPO_DOM     321     339       Cytoplasmic        
TRANSMEM     340     360       Helical        
TOPO_DOM     361     367       Periplasmic        
TRANSMEM     368     388       Helical        
TOPO_DOM     389     Cter       Cytoplasmic        
end case

Additional information [?]

Size range 397-411 amino acids
Related rules None
Fusion None