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| Annotation rule MF_01531 |
General rule information
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| Accession | MF_01531 |
| Dates | 16-FEB-2005 (Created) 19-NOV-2019 (Last updated, Version 29) |
| Name | BtuB |
| Scope | Bacteria; Gammaproteobacteria |
| Template | P06129 (BTUB_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB. |
| Subcellular location | Cell outer membrane; Multi-pass membrane protein. |
| Similarity | Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. |
Keywords
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case <OC:Enterobacterales>
end case
Ion transport
Membrane
Cell outer membrane
Porin
Signal
TonB box
Transmembrane
Transmembrane beta strand
Transport
Membrane
Cell outer membrane
Porin
Signal
TonB box
Transmembrane
Transmembrane beta strand
Transport
Gene Ontology
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GO:0090482; Molecular function: vitamin transmembrane transporter activity.
GO:0015889; Biological process: cobalamin transport.
GO:0009279; Cellular component: cell outer membrane.
GO:0015889; Biological process: cobalamin transport.
GO:0009279; Cellular component: cell outer membrane.
Cross-references
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| Pfam | PF00593; TonB_dep_Rec; 1; |
| TIGRFAMs | TIGR01779; TonB-B12; 1; |
| PROSITE | PS00430; TONB_DEPENDENT_REC_1; 1; |
| PS01156; TONB_DEPENDENT_REC_2; 1; |
Computed features
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| General | Signal; -; 1; trigger=yes; |
Features
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case <OC:Enterobacterales>
| From: BTUB_ECOLI (P06129) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| TRANSMEM | 158 | 165 | Beta stranded | |||||||||
| TRANSMEM | 169 | 178 | Beta stranded | |||||||||
| TRANSMEM | 184 | 195 | Beta stranded | |||||||||
| TRANSMEM | 217 | 227 | Beta stranded | |||||||||
| TRANSMEM | 232 | 248 | Beta stranded | |||||||||
| TRANSMEM | 263 | 277 | Beta stranded | |||||||||
| TRANSMEM | 279 | 296 | Beta stranded | |||||||||
| TRANSMEM | 309 | 325 | Beta stranded | |||||||||
| TRANSMEM | 328 | 337 | Beta stranded | |||||||||
| TRANSMEM | 353 | 369 | Beta stranded | |||||||||
| TRANSMEM | 371 | 381 | Beta stranded | |||||||||
| TRANSMEM | 385 | 400 | Beta stranded | |||||||||
| TRANSMEM | 403 | 417 | Beta stranded | |||||||||
| TRANSMEM | 434 | 443 | Beta stranded | |||||||||
| TRANSMEM | 449 | 458 | Beta stranded | |||||||||
| TRANSMEM | 473 | 490 | Beta stranded | |||||||||
| TRANSMEM | 494 | 509 | Beta stranded | |||||||||
| TRANSMEM | 517 | 529 | Beta stranded | |||||||||
| TRANSMEM | 535 | 550 | Beta stranded | |||||||||
| TRANSMEM | 558 | 572 | Beta stranded | |||||||||
| TRANSMEM | 585 | 596 | Beta stranded | |||||||||
| TRANSMEM | 602 | 614 | Beta stranded | |||||||||
| REGION | 108 | 112 | Cobalamin-binding | A-G-[VIGL]-[ST]-G | ||||||||
| REGION | 249 | 251 | Cobalamin-binding | Y-[DN]-x | ||||||||
| REGION | 515 | 518 | Cobalamin-binding | L-x-R-R | ||||||||
| MOTIF | 26 | 33 | TonB box | |||||||||
| MOTIF | 597 | 614 | TonB C-terminal box | |||||||||
| METAL | 199 | 199 | Calcium 1 | [DN] | ||||||||
| METAL | 211 | 211 | Calcium 1 | Q | ||||||||
| METAL | 213 | 213 | Calcium 1 | D | ||||||||
| METAL | 213 | 213 | Calcium 2 | D | ||||||||
| METAL | 215 | 215 | Calcium 1 | D | ||||||||
| METAL | 215 | 215 | Calcium 2 | D | ||||||||
| METAL | 249 | 249 | Calcium 2; via carbonyl oxygen | Y | ||||||||
| METAL | 250 | 250 | Calcium 1 | D | ||||||||
| METAL | 250 | 250 | Calcium 2 | D | ||||||||
| METAL | 261 | 261 | Calcium 2 | D | ||||||||
end case
case not <OC:Enterobacterales>
end case
Additional information
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| Size range | 606-625 amino acids |
| Related rules | None |
| Fusion | None |