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Annotation rule MF_01531
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General rule information [?]

Accession MF_01531
Dates 16-FEB-2005 (Created)
19-NOV-2019 (Last updated, Version 29)
Name BtuB
Scope
Bacteria; Gammaproteobacteria
Template P06129 (BTUB_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
BTUB
Protein name
RecName: Full=Vitamin B12 transporter BtuB;
AltName: Full=Cobalamin receptor;
AltName: Full=Outer membrane cobalamin translocator;
Flags: Precursor;
Gene name
btuB

Comments [?]

Function Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB.
Subcellular location Cell outer membrane; Multi-pass membrane protein.
Similarity Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.

Keywords [?]

case <OC:Enterobacterales>
end case

Gene Ontology [?]

GO:0090482; Molecular function: vitamin transmembrane transporter activity.
GO:0015889; Biological process: cobalamin transport.
GO:0009279; Cellular component: cell outer membrane.

Cross-references [?]

Pfam PF00593; TonB_dep_Rec; 1;
TIGRFAMs TIGR01779; TonB-B12; 1;
PROSITE PS00430; TONB_DEPENDENT_REC_1; 1;
PS01156; TONB_DEPENDENT_REC_2; 1;

Computed features [?]

General Signal; -; 1; trigger=yes;

Features [?]

case <OC:Enterobacterales>
From: BTUB_ECOLI (P06129)
Key     From     To       Description   Tag   Condition   FTGroup
TRANSMEM     158     165       Beta stranded        
TRANSMEM     169     178       Beta stranded        
TRANSMEM     184     195       Beta stranded        
TRANSMEM     217     227       Beta stranded        
TRANSMEM     232     248       Beta stranded        
TRANSMEM     263     277       Beta stranded        
TRANSMEM     279     296       Beta stranded        
TRANSMEM     309     325       Beta stranded        
TRANSMEM     328     337       Beta stranded        
TRANSMEM     353     369       Beta stranded        
TRANSMEM     371     381       Beta stranded        
TRANSMEM     385     400       Beta stranded        
TRANSMEM     403     417       Beta stranded        
TRANSMEM     434     443       Beta stranded        
TRANSMEM     449     458       Beta stranded        
TRANSMEM     473     490       Beta stranded        
TRANSMEM     494     509       Beta stranded        
TRANSMEM     517     529       Beta stranded        
TRANSMEM     535     550       Beta stranded        
TRANSMEM     558     572       Beta stranded        
TRANSMEM     585     596       Beta stranded        
TRANSMEM     602     614       Beta stranded        
REGION     108     112       Cobalamin-binding     A-G-[VIGL]-[ST]-G  
REGION     249     251       Cobalamin-binding     Y-[DN]-x  
REGION     515     518       Cobalamin-binding     L-x-R-R  
MOTIF     26     33       TonB box        
MOTIF     597     614       TonB C-terminal box        
METAL     199     199       Calcium 1     [DN]  
METAL     211     211       Calcium 1     Q  
METAL     213     213       Calcium 1     D  
METAL     213     213       Calcium 2     D  
METAL     215     215       Calcium 1     D  
METAL     215     215       Calcium 2     D  
METAL     249     249       Calcium 2; via carbonyl oxygen     Y  
METAL     250     250       Calcium 1     D  
METAL     250     250       Calcium 2     D  
METAL     261     261       Calcium 2     D  
end case
case not <OC:Enterobacterales>
MOTIF     26     33       TonB box        
MOTIF     597     614       TonB C-terminal box        
end case

Additional information [?]

Size range 606-625 amino acids
Related rules None
Fusion None