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HAMAP rule MF_01531

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General rule information [?]

Accession MF_01531
Dates 16-FEB-2005 (Created)
1-JUN-2023 (Last updated, Version 35)
Name BtuB
Scope(s) Bacteria
Gammaproteobacteria
Template(s) P06129 (BTUB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01531 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier BTUB
Protein name RecName: Full=Vitamin B12 transporter BtuB;
AltName: Full=Cobalamin receptor;
AltName: Full=Outer membrane cobalamin translocator;
                 Flags: Precursor;
Gene name Name=btuB;

Comments [?]

FUNCTIONInvolved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB.
SUBCELLULAR LOCATIONCell outer membrane; Multi-pass membrane protein.
SIMILARITYBelongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.

Keywords [?]


Gene Ontology [?]

GO:0090482; Molecular function:vitamin transmembrane transporter activity
GO:0015889; Biological process:cobalamin transport
GO:0009279; Cellular component:cell outer membrane

Cross-references [?]

Pfam PF00593; TonB_dep_Rec; 1;
NCBIfam TIGR01779; TonB-B12; 1;
PROSITE PS00430; TONB_DEPENDENT_REC_1; 1;
PROSITE PS01156; TONB_DEPENDENT_REC_2; 1;
PROSITE PS52016; TONB_DEPENDENT_REC_3; 1;
General Signal; -; 1;

Features [?]

From: BTUB_ECOLI (P06129)
Key From To Description Tag Condition FTGroup
case <OC:Enterobacterales>
TRANSMEM 158 165 /note="Beta stranded"
TRANSMEM 169 178 /note="Beta stranded"
TRANSMEM 184 195 /note="Beta stranded"
TRANSMEM 217 227 /note="Beta stranded"
TRANSMEM 232 248 /note="Beta stranded"
TRANSMEM 263 277 /note="Beta stranded"
TRANSMEM 279 296 /note="Beta stranded"
TRANSMEM 309 325 /note="Beta stranded"
TRANSMEM 328 337 /note="Beta stranded"
TRANSMEM 353 369 /note="Beta stranded"
TRANSMEM 371 381 /note="Beta stranded"
TRANSMEM 385 400 /note="Beta stranded"
TRANSMEM 403 417 /note="Beta stranded"
TRANSMEM 434 443 /note="Beta stranded"
TRANSMEM 449 458 /note="Beta stranded"
TRANSMEM 473 490 /note="Beta stranded"
TRANSMEM 494 509 /note="Beta stranded"
TRANSMEM 517 529 /note="Beta stranded"
TRANSMEM 535 550 /note="Beta stranded"
TRANSMEM 558 572 /note="Beta stranded"
TRANSMEM 585 596 /note="Beta stranded"
TRANSMEM 602 614 /note="Beta stranded"
BINDING 110 111 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
[VIGL]-[ST]
BINDING 83 83 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
L
BINDING 85 85 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
[ST]
BINDING 92 92 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
N
BINDING 251 251 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
[ASG]
BINDING 309 309 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
[TS]
BINDING 517 517 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
R
BINDING 551 551 /ligand="cyanocob(III)alamin"
/ligand_id="ChEBI:CHEBI:17439"
[YF]
MOTIF 26 33 /note="TonB box"
MOTIF 597 614 /note="TonB C-terminal box"
BINDING 199 199 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="1"
[DN]
BINDING 211 211 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="1"
Q
BINDING 213 213 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="1"
D
BINDING 213 213 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="2"
D
BINDING 215 215 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="1"
D
BINDING 215 215 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="2"
D
BINDING 249 249 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="2"
Y
BINDING 250 250 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="1"
D
BINDING 250 250 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="2"
D
BINDING 261 261 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="2"
D
end case
case not <OC:Enterobacterales>
MOTIF 26 33 /note="TonB box"
MOTIF 597 614 /note="TonB C-terminal box"
end case

Additional information [?]

Size range 606-625 amino acids
Related rules None
Fusion Nter: None Cter: None



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