HAMAP rule MF_01531
General rule information
[?]
| Accession | MF_01531 |
| Dates | 16-FEB-2005 (Created)
1-JUN-2023 (Last updated, Version 35) |
| Name | BtuB |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P06129 (BTUB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01531 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | BTUB |
| Protein name | RecName: Full=Vitamin B12 transporter BtuB; AltName: Full=Cobalamin receptor; AltName: Full=Outer membrane cobalamin translocator; Flags: Precursor; |
| Gene name | Name=btuB; |
Comments
[?]
| FUNCTION | Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB. |
| SUBCELLULAR LOCATION | Cell outer membrane; Multi-pass membrane protein. |
| SIMILARITY | Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily. |
Keywords
[?]
| case <OC:Enterobacterales> | |
| Calcium | |
| Metal-binding | |
| end case | |
| Ion transport | |
| Membrane | |
| Cell outer membrane | |
| Porin | |
| Signal | |
| TonB box | |
| Transmembrane | |
| Transmembrane beta strand | |
| Transport | |
Gene Ontology
[?]
| GO:0090482; Molecular function:vitamin transmembrane transporter activity |
| GO:0015889; Biological process:cobalamin transport |
| GO:0009279; Cellular component:cell outer membrane |
Cross-references
[?]
| Pfam | PF00593; TonB_dep_Rec; 1; |
| NCBIfam | TIGR01779; TonB-B12; 1; |
| PROSITE | PS00430; TONB_DEPENDENT_REC_1; 1; |
| PROSITE | PS01156; TONB_DEPENDENT_REC_2; 1; |
| PROSITE | PS52016; TONB_DEPENDENT_REC_3; 1; |
| General | Signal; -; 1; |
Features
[?]
| From: BTUB_ECOLI (P06129) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <OC:Enterobacterales> | ||||||||||||
| TRANSMEM | 158 | 165 | /note="Beta stranded" | |||||||||
| TRANSMEM | 169 | 178 | /note="Beta stranded" | |||||||||
| TRANSMEM | 184 | 195 | /note="Beta stranded" | |||||||||
| TRANSMEM | 217 | 227 | /note="Beta stranded" | |||||||||
| TRANSMEM | 232 | 248 | /note="Beta stranded" | |||||||||
| TRANSMEM | 263 | 277 | /note="Beta stranded" | |||||||||
| TRANSMEM | 279 | 296 | /note="Beta stranded" | |||||||||
| TRANSMEM | 309 | 325 | /note="Beta stranded" | |||||||||
| TRANSMEM | 328 | 337 | /note="Beta stranded" | |||||||||
| TRANSMEM | 353 | 369 | /note="Beta stranded" | |||||||||
| TRANSMEM | 371 | 381 | /note="Beta stranded" | |||||||||
| TRANSMEM | 385 | 400 | /note="Beta stranded" | |||||||||
| TRANSMEM | 403 | 417 | /note="Beta stranded" | |||||||||
| TRANSMEM | 434 | 443 | /note="Beta stranded" | |||||||||
| TRANSMEM | 449 | 458 | /note="Beta stranded" | |||||||||
| TRANSMEM | 473 | 490 | /note="Beta stranded" | |||||||||
| TRANSMEM | 494 | 509 | /note="Beta stranded" | |||||||||
| TRANSMEM | 517 | 529 | /note="Beta stranded" | |||||||||
| TRANSMEM | 535 | 550 | /note="Beta stranded" | |||||||||
| TRANSMEM | 558 | 572 | /note="Beta stranded" | |||||||||
| TRANSMEM | 585 | 596 | /note="Beta stranded" | |||||||||
| TRANSMEM | 602 | 614 | /note="Beta stranded" | |||||||||
| BINDING | 110 | 111 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
[VIGL]-[ST] | ||||||||
| BINDING | 83 | 83 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
L | ||||||||
| BINDING | 85 | 85 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
[ST] | ||||||||
| BINDING | 92 | 92 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
N | ||||||||
| BINDING | 251 | 251 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
[ASG] | ||||||||
| BINDING | 309 | 309 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
[TS] | ||||||||
| BINDING | 517 | 517 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
R | ||||||||
| BINDING | 551 | 551 | /ligand="cyanocob(III)alamin" /ligand_id="ChEBI:CHEBI:17439" |
[YF] | ||||||||
| MOTIF | 26 | 33 | /note="TonB box" | |||||||||
| MOTIF | 597 | 614 | /note="TonB C-terminal box" | |||||||||
| BINDING | 199 | 199 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" |
[DN] | ||||||||
| BINDING | 211 | 211 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" |
Q | ||||||||
| BINDING | 213 | 213 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" |
D | ||||||||
| BINDING | 213 | 213 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" |
D | ||||||||
| BINDING | 215 | 215 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" |
D | ||||||||
| BINDING | 215 | 215 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" |
D | ||||||||
| BINDING | 249 | 249 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" |
Y | ||||||||
| BINDING | 250 | 250 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="1" |
D | ||||||||
| BINDING | 250 | 250 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" |
D | ||||||||
| BINDING | 261 | 261 | /ligand="Ca(2+)" /ligand_id="ChEBI:CHEBI:29108" /ligand_label="2" |
D | ||||||||
| end case | ||||||||||||
| case not <OC:Enterobacterales> | ||||||||||||
| MOTIF | 26 | 33 | /note="TonB box" | |||||||||
| MOTIF | 597 | 614 | /note="TonB C-terminal box" | |||||||||
| end case | ||||||||||||
Additional information
[?]
| Size range | 606-625 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |