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HAMAP rule MF_01539

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General rule information [?]

Accession MF_01539
Dates 12-AUG-2005 (Created)
1-JUN-2023 (Last updated, Version 18)
Name TmcAL
Scope(s) Bacteria
Template(s) O34513 (TMCAL_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01539 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier TMCAL
Protein name RecName: Full=tRNA(Met) cytidine acetate ligase;
Gene name Name=tmcAL;

Comments [?]

FUNCTIONCatalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
CATALYTIC ACTIVITY Reaction=acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met); Xref=Rhea:RHEA:58144, Rhea:RHEA-COMP:10693, Rhea:RHEA-COMP:10694, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456215;
SIMILARITYBelongs to the TmcAL family.

Keywords [?]

Gene Ontology [?]

GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds
GO:0006400; Biological process:tRNA modification
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF05636; HIGH_NTase1; 1;
NCBIfam TIGR00125; cyt_tran_rel; 1;

Features [?]

From: TMCAL_BACSU (O34513)
Key From To Description Tag Condition FTGroup
BINDING 7 20 /ligand="ATP"
BINDING 187 188 /ligand="ATP"
BINDING 101 101 /ligand="ATP"
BINDING 162 162 /ligand="ATP"
case not <FT:2>
BINDING 187 187 /ligand="ATP"
end case

Additional information [?]

Size range 298-426 amino acids
Related rules None
Fusion Nter: None Cter: None

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