HAMAP rule MF_01539
General rule information
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| Accession | MF_01539 |
| Dates | 12-AUG-2005 (Created)
1-JUN-2023 (Last updated, Version 18) |
| Name | TmcAL |
| Scope(s) |
Bacteria |
| Template(s) | O34513 (TMCAL_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01539 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | TMCAL |
| Protein name | RecName: Full=tRNA(Met) cytidine acetate ligase; EC=6.3.4.-; |
| Gene name | Name=tmcAL; |
Comments
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| FUNCTION | Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. |
| CATALYTIC ACTIVITY | Reaction=acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met); Xref=Rhea:RHEA:58144, Rhea:RHEA-COMP:10693, Rhea:RHEA-COMP:10694, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:74900, ChEBI:CHEBI:82748, ChEBI:CHEBI:456215; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the TmcAL family. |
Keywords
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Gene Ontology
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| GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds |
| GO:0006400; Biological process:tRNA modification |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: TMCAL_BACSU (O34513) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 7 | 20 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 187 | 188 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R-I | ||||||||
| BINDING | 101 | 101 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
G | ||||||||
| BINDING | 162 | 162 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
N | ||||||||
| case not <FT:2> | ||||||||||||
| BINDING | 187 | 187 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
R | ||||||||
| end case | ||||||||||||
Additional information
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| Size range | 298-426 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |