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Annotation rule MF_01539
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General rule information [?]

Accession MF_01539
Dates 12-AUG-2005 (Created)
19-NOV-2019 (Last updated, Version 15)
Name TmcAL
Scope
Bacteria
Template O34513 (TMCAL_BACSU)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
TMCAL
Protein name
RecName: Full=tRNA(Met) cytidine acetate ligase;
EC 6.3.4.-;
Gene name
tmcAL

Comments [?]

Function Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.
Catalytic activity RHEA:58144: acetate + ATP + cytidine(34) in elongator tRNA(Met) = AMP + diphosphate + N(4)-acetylcytidine(34) in elongator tRNA(Met)
Subcellular location Cytoplasm.
Similarity Belongs to the TmcAL family.

Keywords [?]

ATP-binding
Cytoplasm
Ligase
Nucleotide-binding
RNA-binding
tRNA processing
tRNA-binding

Gene Ontology [?]

GO:0016879; Molecular function: ligase activity, forming carbon-nitrogen bonds.
GO:0006400; Biological process: tRNA modification.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

Pfam PF05636; HIGH_NTase1; 1;
TIGRFAMs TIGR00125; cyt_tran_rel; 1;

Features [?]

From: TMCAL_BACSU (O34513)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     7     20       ATP        
NP_BIND (Optional)     187     188       ATP     R-I  
BINDING (Optional)     101     101       ATP; via amide nitrogen     G  
BINDING (Optional)     162     162       ATP     N  
case not <FT:2>
BINDING (Optional)     187     187       ATP     R  
end case

Additional information [?]

Size range 298-426 amino acids
Related rules None
Fusion None


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