HAMAP rule MF_01540

General rule information [?]

Accession	MF_01540
Dates	22-AUG-2005 (Created) 1-JUN-2023 (Last updated, Version 16)

Name

CysI

Scope

Bacteria

Templates

P17846 (CYSI_ECOLI); P17845 (CYSI_SALTY); O32213 (CYSI_BACSU); Q8KQT8 (CYSI_XANOR): [Recover all]

Triggered by

HAMAP; MF_01540 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CYSI

Protein name

RecName:		Full=Sulfite reductase [NADPH] hemoprotein beta-component;
		Short=SiR-HP;
		Short=SiRHP;
		EC 1.8.1.2;

Gene name

cysI

Comments [?]

Function	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.
Catalytic activity	RHEA:13801: 3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite EC 1.8.1.2
Cofactor	siroheme Note: Binds 1 siroheme per subunit.
	[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit.
Pathway	Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.
Subunit	Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein.
Similarity	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.

Keywords [?]

4Fe-4S
Amino-acid biosynthesis
Cysteine biosynthesis
Heme
Iron
Iron-sulfur
Metal-binding
NADP
Oxidoreductase

Gene Ontology [?]

GO:0004783; Molecular function: sulfite reductase (NADPH) activity.
GO:0000103; Biological process: sulfate assimilation.
GO:0070814; Biological process: hydrogen sulfide biosynthetic process.

Cross-references [?]

PROSITE	PS00365; NIR_SIR; 1;
Pfam	PF01077; NIR_SIR; 1;
	PF03460; NIR_SIR_ferr; 2;
PRINTS	PR00397; SIROHAEM; 1;
NCBIfam	TIGR02041; CysI; 1;

Features [?]

From: CYSI_ECOLI (P17846)

Key From To Description Tag Condition FTGroup

BINDING 434 434 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

BINDING 440 440 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

BINDING 479 479 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

BINDING 483 483 /ligand="siroheme" /ligand_id="ChEBI:CHEBI:60052" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue C

BINDING 483 483 /ligand="[4Fe-4S] cluster" /ligand_id="ChEBI:CHEBI:49883 C

Additional information [?]

Size range	555-616 amino acids
Related rules	None
Fusion	None

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