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Annotation rule MF_01540 |
Accession | MF_01540 |
Dates | 22-AUG-2005 (Created) 19-NOV-2019 (Last updated, Version 13) |
Name | CysI |
Scope | Bacteria |
Templates | P17846 (CYSI_ECOLI); P17845 (CYSI_SALTY); O32213 (CYSI_BACSU); Q8KQT8 (CYSI_XANOR): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. |
Catalytic activity | RHEA:13801: 3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite
EC 1.8.1.2 |
Cofactor | siroheme Note: Binds 1 siroheme per subunit. |
[4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. |
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Pathway | Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. |
Subunit | Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein. |
Similarity | Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. |
PROSITE | PS00365; NIR_SIR; 1; |
Pfam | PF01077; NIR_SIR; 1; |
PF03460; NIR_SIR_ferr; 2; | |
PRINTS | PR00397; SIROHAEM; 1; |
TIGRFAMs | TIGR02041; CysI; 1; |
From: CYSI_ECOLI (P17846) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
METAL | 434 | 434 | Iron-sulfur (4Fe-4S) | C | ||||||||
METAL | 440 | 440 | Iron-sulfur (4Fe-4S) | C | ||||||||
METAL | 479 | 479 | Iron-sulfur (4Fe-4S) | C | ||||||||
METAL | 483 | 483 | Iron (siroheme axial ligand) | C | ||||||||
METAL | 483 | 483 | Iron-sulfur (4Fe-4S) | C |
Size range | 555-616 amino acids |
Related rules | None |
Fusion | None |