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| Annotation rule MF_01540 |
General rule information
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| Accession | MF_01540 |
| Dates | 22-AUG-2005 (Created) 19-NOV-2019 (Last updated, Version 13) |
| Name | CysI |
| Scope | Bacteria |
| Templates | P17846 (CYSI_ECOLI); P17845 (CYSI_SALTY); O32213 (CYSI_BACSU); Q8KQT8 (CYSI_XANOR): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. |
| Catalytic activity | RHEA:13801: 3 H2O + hydrogen sulfide + 3 NADP(+) = 4 H(+) + 3 NADPH + sulfite
EC 1.8.1.2 |
| Cofactor | siroheme Note: Binds 1 siroheme per subunit. |
| [4Fe-4S] cluster Note: Binds 1 [4Fe-4S] cluster per subunit. |
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| Pathway | Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1. |
| Subunit | Alpha(8)-beta(8). The alpha component is a flavoprotein, the beta component is a hemoprotein. |
| Similarity | Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. |
Keywords
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4Fe-4S
Amino-acid biosynthesis
Cysteine biosynthesis
Heme
Iron
Iron-sulfur
Metal-binding
NADP
Oxidoreductase
Amino-acid biosynthesis
Cysteine biosynthesis
Heme
Iron
Iron-sulfur
Metal-binding
NADP
Oxidoreductase
Gene Ontology
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GO:0004783; Molecular function: sulfite reductase (NADPH) activity.
GO:0000103; Biological process: sulfate assimilation.
GO:0070814; Biological process: hydrogen sulfide biosynthetic process.
GO:0000103; Biological process: sulfate assimilation.
GO:0070814; Biological process: hydrogen sulfide biosynthetic process.
Cross-references
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| PROSITE | PS00365; NIR_SIR; 1; |
| Pfam | PF01077; NIR_SIR; 1; |
| PF03460; NIR_SIR_ferr; 2; | |
| PRINTS | PR00397; SIROHAEM; 1; |
| TIGRFAMs | TIGR02041; CysI; 1; |
Features
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| From: CYSI_ECOLI (P17846) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| METAL | 434 | 434 | Iron-sulfur (4Fe-4S) | C | ||||||||
| METAL | 440 | 440 | Iron-sulfur (4Fe-4S) | C | ||||||||
| METAL | 479 | 479 | Iron-sulfur (4Fe-4S) | C | ||||||||
| METAL | 483 | 483 | Iron (siroheme axial ligand) | C | ||||||||
| METAL | 483 | 483 | Iron-sulfur (4Fe-4S) | C | ||||||||
Additional information
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| Size range | 555-616 amino acids |
| Related rules | None |
| Fusion | None |