Home  |  Contact
Annotation rule MF_01543
Send feedback

General rule information [?]

Accession MF_01543
Dates 15-NOV-2005 (Created)
19-NOV-2022 (Last updated, Version 22)
Name FTHFS
Scope
Bacteria
Archaea; Euryarchaeota
Templates P21164 (FTHS_MOOTH); Q83WS0 (FTHS_METEA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FTHS
Protein name
RecName: Full=Formate--tetrahydrofolate ligase;
EC 6.3.4.3;
AltName: Full=Formyltetrahydrofolate synthetase;
Short=FHS;
Short=FTHFS;
Gene name
fhs

Comments [?]

Catalytic activity RHEA:20221: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate
EC 6.3.4.3
Pathway One-carbon metabolism; tetrahydrofolate interconversion.
Similarity Belongs to the formate--tetrahydrofolate ligase family.

Keywords [?]

ATP-binding
Ligase
Nucleotide-binding
One-carbon metabolism

Gene Ontology [?]

GO:0004329; Molecular function: formate-tetrahydrofolate ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006730; Biological process: one-carbon metabolic process.

Cross-references [?]

PROSITE PS00721; FTHFS_1; 1;
PS00722; FTHFS_2; 1;
Pfam PF01268; FTHFS; 1;

Features [?]

From: FTHS_MOOTH (P21164)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING     68     75       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616     [TS]-x-x-G-[EIV]-G-K-[TS]  

Additional information [?]

Size range 505-597 amino acids
Related rules None
Fusion None


View rule in raw text format (no links)