HAMAP rule MF_01543
General rule information
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Accession | MF_01543 |
Dates | 15-NOV-2005 (Created) 19-NOV-2022 (Last updated, Version 22) |
Name | FTHFS |
Scope | Bacteria
Archaea; Euryarchaeota |
Templates | P21164 (FTHS_MOOTH); Q83WS0 (FTHS_METEA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Catalytic activity | RHEA:20221: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate
EC 6.3.4.3 |
Pathway | One-carbon metabolism; tetrahydrofolate interconversion. |
Similarity | Belongs to the formate--tetrahydrofolate ligase family. |
Keywords
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Gene Ontology
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GO:0004329; Molecular function: formate-tetrahydrofolate ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006730; Biological process: one-carbon metabolic process.
GO:0005524; Molecular function: ATP binding.
GO:0006730; Biological process: one-carbon metabolic process.
Cross-references
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Features
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From: FTHS_MOOTH (P21164) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
BINDING | 68 | 75 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 | [TS]-x-x-G-[EIV]-G-K-[TS] |
Additional information
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Size range | 505-597 amino acids |
Related rules | None |
Fusion | None |