HAMAP rule MF_01543

General rule information [?]

Accession	MF_01543
Dates	15-NOV-2005 (Created) 19-NOV-2022 (Last updated, Version 22)

Name

FTHFS

Scope

Bacteria

Archaea; Euryarchaeota

Templates

P21164 (FTHS_MOOTH); Q83WS0 (FTHS_METEA): [Recover all]

Triggered by

HAMAP; MF_01543 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

FTHS

Protein name

RecName:		Full=Formate--tetrahydrofolate ligase;
		EC 6.3.4.3;
AltName:		Full=Formyltetrahydrofolate synthetase;
		Short=FHS;
		Short=FTHFS;

Gene name

fhs

Comments [?]

Catalytic activity	RHEA:20221: (6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6S)-10-formyltetrahydrofolate + ADP + phosphate EC 6.3.4.3
Pathway	One-carbon metabolism; tetrahydrofolate interconversion.
Similarity	Belongs to the formate--tetrahydrofolate ligase family.

Keywords [?]

ATP-binding
Ligase
Nucleotide-binding
One-carbon metabolism

Gene Ontology [?]

GO:0004329; Molecular function: formate-tetrahydrofolate ligase activity.
GO:0005524; Molecular function: ATP binding.
GO:0006730; Biological process: one-carbon metabolic process.

Cross-references [?]

PROSITE	PS00721; FTHFS_1; 1;
	PS00722; FTHFS_2; 1;
Pfam	PF01268; FTHFS; 1;

Features [?]

From: FTHS_MOOTH (P21164)

Key From To Description Tag Condition FTGroup

BINDING 68 75 /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616 [TS]-x-x-G-[EIV]-G-K-[TS]

Additional information [?]

Size range	505-597 amino acids
Related rules	None
Fusion	None

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