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HAMAP rule MF_01543

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General rule information [?]

Accession MF_01543
Dates 15-NOV-2005 (Created)
18-JUL-2023 (Last updated, Version 23)
Scope(s) Bacteria
Template(s) P21164 (FTHS_MOOTH); Q83WS0 (FTHS_METEA); [ Recover all ]
Triggered by HAMAP; MF_01543 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier FTHS
Protein name RecName: Full=Formate--tetrahydrofolate ligase;
AltName: Full=Formyltetrahydrofolate synthetase;
Gene name Name=fhs;

Comments [?]

CATALYTIC ACTIVITY Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10- formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216; EC=;
PATHWAYOne-carbon metabolism; tetrahydrofolate interconversion.
SIMILARITYBelongs to the formate--tetrahydrofolate ligase family.

Keywords [?]

Gene Ontology [?]

GO:0004329; Molecular function:formate-tetrahydrofolate ligase activity
GO:0005524; Molecular function:ATP binding
GO:0006730; Biological process:one-carbon metabolic process

Cross-references [?]

PROSITE PS00721; FTHFS_1; 1;
PROSITE PS00722; FTHFS_2; 1;
Pfam PF01268; FTHFS; 1;

Features [?]

From: FTHS_MOOTH (P21164)
Key From To Description Tag Condition FTGroup
BINDING 68 75 /ligand="ATP"

Additional information [?]

Size range 505-597 amino acids
Related rules None
Fusion Nter: None Cter: None

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