HAMAP rule MF_01543
General rule information
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| Accession | MF_01543 |
| Dates | 15-NOV-2005 (Created)
7-MAY-2024 (Last updated, Version 24) |
| Name | FTHFS |
| Scope(s) |
Bacteria Archaea Euryarchaeota |
| Template(s) | P21164 (FTHS_MOOTH); Q83WS0 (FTHS_METEA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01543 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FTHS |
| Protein name | RecName: Full=Formate--tetrahydrofolate ligase; EC=6.3.4.3; AltName: Full=Formyltetrahydrofolate synthetase; Short=FHS; Short=FTHFS; |
| Gene name | Name=fhs; |
Comments
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| CATALYTIC ACTIVITY | Reaction=(6S)-5,6,7,8-tetrahydrofolate + ATP + formate = (6R)-10- formyltetrahydrofolate + ADP + phosphate; Xref=Rhea:RHEA:20221, ChEBI:CHEBI:15740, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57453, ChEBI:CHEBI:195366, ChEBI:CHEBI:456216; EC=6.3.4.3; |
| PATHWAY | One-carbon metabolism; tetrahydrofolate interconversion. |
| SIMILARITY | Belongs to the formate--tetrahydrofolate ligase family. |
Keywords
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Gene Ontology
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| GO:0004329; Molecular function:formate-tetrahydrofolate ligase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0035999; Biological process:tetrahydrofolate interconversion |
Cross-references
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Features
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| From: FTHS_MOOTH (P21164) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 68 | 75 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[TS]-x-x-G-[EIV]-G-K-[TS] | ||||||||
Additional information
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| Size range | 505-597 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |