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Annotation rule MF_01547
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General rule information [?]

Accession MF_01547
Dates 22-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 25)
Name RNA_methyltr_E
Scope
Bacteria
Archaea
Template P0C0R7 (RLME_ECOLI)
case <OC:Bacteria> or <OC:Archaea>
end case


Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
RLME
Protein name
RecName: Full=Ribosomal RNA large subunit methyltransferase E;
EC 2.1.1.166;
AltName: Full=23S rRNA Um2552 methyltransferase;
AltName: Full=rRNA (uridine-2'-O-)-methyltransferase;
case <OC:Bacteria>
Gene name
rlmE, ftsJ, rrmJ
else case <OC:Archaea>
Gene name
rlmE
end case

Comments [?]

Function Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
Catalytic activity RHEA:42720: S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.166
Subcellular location Cytoplasm.
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.

Keywords [?]


Gene Ontology [?]

GO:0008650; Molecular function: rRNA (uridine-2'-O-)-methyltransferase activity.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS50926; TRAM; 0-1; trigger=PRU00208;
Pfam PF01728; FtsJ; 1;
PF01938; TRAM; 0-1;
PIRSF PIRSF005461; 23S_rRNA_mtase; 1;
TIGRFAMs TIGR00438; RrmJ; 1;

Features [?]

From: RLME_ECOLI (P0C0R7)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     164     164       Proton acceptor     K  
BINDING     63     63       S-adenosyl-L-methionine; via amide nitrogen     G   1
BINDING     65     65       S-adenosyl-L-methionine; via amide nitrogen     [WF]   1
BINDING     83     83       S-adenosyl-L-methionine     D   1
BINDING     99     99       S-adenosyl-L-methionine     [DN]   1
BINDING     124     124       S-adenosyl-L-methionine     D   1

Additional information [?]

Size range 189-279 amino acids
Related rules MF_03162 (TRM7 supersedes the current rule); MF_03163 (SPB1 supersedes the current rule)
Fusion None