HAMAP rule MF_01547
General rule information
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Accession | MF_01547 |
Dates | 22-NOV-2005 (Created) 19-NOV-2022 (Last updated, Version 27) |
Name | RNA_methyltr_E |
Scope | Bacteria
Archaea |
Template | P0C0R7 (RLME_ECOLI) |
case <OC:Bacteria> or <OC:Archaea>
Triggered by |
end case
Propagated annotation
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Identifier, protein and gene names
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Identifier |
|
Protein name |
|
case <OC:Bacteria>
Gene name |
|
else case <OC:Archaea>
Gene name |
|
end case
Comments
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Function | Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. |
Catalytic activity | RHEA:42720: S-adenosyl-L-methionine + uridine(2552) in 23S rRNA = 2'-O-methyluridine(2552) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine
EC 2.1.1.166 |
Subcellular location | Cytoplasm. |
Similarity | Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. |
Keywords
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Gene Ontology
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GO:0008650; Molecular function: rRNA (uridine-2'-O-)-methyltransferase activity.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.
GO:0006364; Biological process: rRNA processing.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS50926; TRAM; 0-1; trigger=PRU00208; |
Pfam | PF01728; FtsJ; 1; |
PF01938; TRAM; 0-1; | |
PIRSF | PIRSF005461; 23S_rRNA_mtase; 1; |
TIGRFAMs | TIGR00438; RrmJ; 1; |
Features
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From: RLME_ECOLI (P0C0R7) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 164 | 164 | Proton acceptor | K | ||||||||
BINDING | 63 | 63 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | G | 1 | |||||||
BINDING | 65 | 65 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [WF] | 1 | |||||||
BINDING | 83 | 83 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | 1 | |||||||
BINDING | 99 | 99 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | [DN] | 1 | |||||||
BINDING | 124 | 124 | /ligand="S-adenosyl-L-methionine" /ligand_id="ChEBI:CHEBI:59789 | D | 1 |
Additional information
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Size range | 189-279 amino acids |
Related rules | MF_03162 (TRM7 supersedes the current rule); MF_03163 (SPB1 supersedes the current rule) |
Fusion | None |