HAMAP rule MF_01550

General rule information [?]

Accession	MF_01550
Dates	25-NOV-2005 (Created) 19-NOV-2019 (Last updated, Version 15)
Name	GppA
Scope(s)	Bacteria Gammaproteobacteria
Template(s)	P25552 (GPPA_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01550 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	GPPA
Protein name	RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; EC=3.6.1.40; AltName: Full=Guanosine pentaphosphate phosphohydrolase; AltName: Full=pppGpp-5'-phosphohydrolase;
Gene name	Name=gppA;

Comments [?]

FUNCTION	Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
CATALYTIC ACTIVITY	Reaction=guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate; Xref=Rhea:RHEA:13073, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:77828, ChEBI:CHEBI:142410; EC=3.6.1.40;
PATHWAY	Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2.
SIMILARITY	Belongs to the GppA/Ppx family. GppA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008894; Molecular function:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity

GO:0015974; Biological process:guanosine pentaphosphate catabolic process

Cross-references [?]

Pfam	PF02541; Ppx-GppA; 1;
PIRSF	PIRSF001267; Pyrophosphatase_GppA_Ppx; 1;

Features [?]

Additional information [?]