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HAMAP rule MF_01550

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General rule information [?]

Accession MF_01550
Dates 25-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 15)
Name GppA
Scope(s) Bacteria
Template(s) P25552 (GPPA_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01550 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier GPPA
Protein name RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
AltName: Full=Guanosine pentaphosphate phosphohydrolase;
AltName: Full=pppGpp-5'-phosphohydrolase;
Gene name Name=gppA;

Comments [?]

FUNCTIONCatalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
CATALYTIC ACTIVITY Reaction=guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate; Xref=Rhea:RHEA:13073, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:77828, ChEBI:CHEBI:142410; EC=;
PATHWAYPurine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2.
SIMILARITYBelongs to the GppA/Ppx family. GppA subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008894; Molecular function:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity
GO:0015974; Biological process:guanosine pentaphosphate catabolic process

Cross-references [?]

Pfam PF02541; Ppx-GppA; 1;
PIRSF PIRSF001267; Pyrophosphatase_GppA_Ppx; 1;

Features [?]

Additional information [?]

Size range 475-525 amino acids
Related rules None
Fusion Nter: None Cter: None

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