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Annotation rule MF_01550 |
Accession | MF_01550 |
Dates | 25-NOV-2005 (Created) 19-NOV-2019 (Last updated, Version 15) |
Name | GppA |
Scope | Bacteria; Gammaproteobacteria |
Template | P25552 (GPPA_ECOLI) |
Triggered by |
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Protein name |
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Function | Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. |
Catalytic activity | RHEA:13073: guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate
EC 3.6.1.40 |
Pathway | Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2. |
Similarity | Belongs to the GppA/Ppx family. GppA subfamily. |
Pfam | PF02541; Ppx-GppA; 1; |
PIRSF | PIRSF001267; Pyrophosphatase_GppA_Ppx; 1; |
Size range | 475-525 amino acids |
Related rules | None |
Fusion | None |