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Annotation rule MF_01550
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General rule information [?]

Accession MF_01550
Dates 25-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 15)
Name GppA
Scope
Bacteria; Gammaproteobacteria
Template P25552 (GPPA_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GPPA
Protein name
RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase;
EC 3.6.1.40;
AltName: Full=Guanosine pentaphosphate phosphohydrolase;
AltName: Full=pppGpp-5'-phosphohydrolase;
Gene name
gppA

Comments [?]

Function Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.
Catalytic activity RHEA:13073: guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate
EC 3.6.1.40
Pathway Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2.
Similarity Belongs to the GppA/Ppx family. GppA subfamily.

Keywords [?]

Hydrolase

Gene Ontology [?]

GO:0008894; Molecular function: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity.
GO:0015974; Biological process: guanosine pentaphosphate catabolic process.

Cross-references [?]

Pfam PF02541; Ppx-GppA; 1;
PIRSF PIRSF001267; Pyrophosphatase_GppA_Ppx; 1;

Additional information [?]

Size range 475-525 amino acids
Related rules None
Fusion None


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