HAMAP rule MF_01550
General rule information
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Accession | MF_01550 |
Dates | 25-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 15) |
Name | GppA |
Scope(s) |
Bacteria Gammaproteobacteria |
Template(s) | P25552 (GPPA_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01550 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | GPPA |
Protein name | RecName: Full=Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase; EC=3.6.1.40; AltName: Full=Guanosine pentaphosphate phosphohydrolase; AltName: Full=pppGpp-5'-phosphohydrolase; |
Gene name | Name=gppA; |
Comments
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FUNCTION | Catalyzes the conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the 'stringent response', an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities. |
CATALYTIC ACTIVITY | Reaction=guanosine 3'-diphosphate 5'-triphosphate + H2O = guanosine 3',5'-bis(diphosphate) + H(+) + phosphate; Xref=Rhea:RHEA:13073, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474, ChEBI:CHEBI:77828, ChEBI:CHEBI:142410; EC=3.6.1.40; |
PATHWAY | Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 2/2. |
SIMILARITY | Belongs to the GppA/Ppx family. GppA subfamily. |
Keywords
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Gene Ontology
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GO:0008894; Molecular function:guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity |
GO:0015974; Biological process:guanosine pentaphosphate catabolic process |
Cross-references
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Pfam | PF02541; Ppx-GppA; 1; |
PIRSF | PIRSF001267; Pyrophosphatase_GppA_Ppx; 1; |
Features
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Additional information
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Size range | 475-525 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |