HAMAP rule MF_01551

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01551
Accession	MF_01551
Dates	28-NOV-2005 (Created) 03-SEP-2024 (Last updated, Version 23)
Name	23SrRNA_methyltr_M
Scope(s)	Bacteria Pseudomonadota
Template(s)	P0ADR6; [ Recover all ]
Triggered by	HAMAP; MF_01551 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	RLMM
Protein name	RecName: Full=Ribosomal RNA large subunit methyltransferase M; EC=2.1.1.186; AltName: Full=23S rRNA (cytidine2498-2'-O)-methyltransferase; AltName: Full=23S rRNA 2'-O-ribose methyltransferase RlmM;
Gene name	Name=rlmM;

Comments [?]

FUNCTION	Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.
CATALYTIC ACTIVITY	Reaction=cytidine(2498) in 23S rRNA + S-adenosyl-L-methionine = 2'-O- methylcytidine(2498) in 23S rRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:42788, Rhea:RHEA-COMP:10244, Rhea:RHEA-COMP:10245, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:74495, ChEBI:CHEBI:82748; EC=2.1.1.186;
SUBUNIT	Monomer.
SUBCELLULAR LOCATION	Cytoplasm.
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.

Keywords [?]

Gene Ontology [?]

GO:0008757; Molecular function:S-adenosylmethionine-dependent methyltransferase activity

GO:0006364; Biological process:rRNA processing

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam	PF01728; FtsJ; 1;
PIRSF	PIRSF028774; UCP028774; 1;

Features [?]

From: RLMM_ECOLI (P0ADR6)

Key

From

Description

Tag

Condition

FTGroup

ACT_SITE

306

/note="Proton acceptor"

BINDING

221

224