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Annotation rule MF_01552 |
General rule information
[?]
Accession |
MF_01552 |
Dates |
30-NOV-2005 (Created) 19-NOV-2019 (Last updated, Version 17) |
Scope |
Bacteria; Cyanobacteria
Bacteria; Planctomycetes
Bacteria; Proteobacteria
Archaea; Methanomicrobia |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Protein name |
RecName:
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Full=Ribosomal protein S6--L-glutamate ligase;
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EC 6.3.2.-;
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AltName:
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Full=Poly-alpha-glutamate synthase;
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AltName:
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Full=Ribosomal protein S6 modification protein;
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else
Protein name |
RecName:
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Full=Probable alpha-L-glutamate ligase;
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EC 6.3.2.-;
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|
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
Function |
Is an L-glutamate ligase that catalyzes the ATP-dependent post-translational addition of glutamate residues to the C-terminus of ribosomal protein S6 (RpsF). Is also able to catalyze the synthesis of poly-alpha-glutamate in vitro, via ATP hydrolysis from unprotected glutamate as substrate. The number of glutamate residues added to either RpsF or to poly-alpha-glutamate changes with pH. |
end case
case <FTGroup:1>
Cofactor |
Mg(2+) Mn(2+) Note: Binds 2 magnesium or manganese ions per subunit. |
end case
Similarity |
Belongs to the RimK family. |
case <FTGroup:1>
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
GO:0018169; Molecular function: ribosomal S6-glutamic acid ligase activity.
GO:0018410; Biological process: C-terminal protein amino acid modification.
else
GO:0016881; Molecular function: acid-amino acid ligase activity.
end case
From: RIMK_ECOLI (P0C0U4) |
Key
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From
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To
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Description
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Tag
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|
Condition
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FTGroup
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NP_BIND
|
|
178
|
|
179
|
|
ATP
|
|
|
|
[EDQ]-[YF]
|
|
|
NP_BIND
|
|
211
|
|
213
|
|
ATP
|
|
|
|
R-[SA]-N
|
|
|
METAL
|
|
248
|
|
248
|
|
Magnesium or manganese 1
|
|
|
|
D
|
|
1
|
METAL
|
|
260
|
|
260
|
|
Magnesium or manganese 1
|
|
|
|
E
|
|
1
|
METAL
|
|
260
|
|
260
|
|
Magnesium or manganese 2
|
|
|
|
E
|
|
1
|
METAL
|
|
262
|
|
262
|
|
Magnesium or manganese 2
|
|
|
|
N
|
|
1
|
BINDING
|
|
141
|
|
141
|
|
ATP
|
|
|
|
K
|
|
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BINDING
|
|
187
|
|
187
|
|
ATP
|
|
|
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D
|
|
|
Additional information
[?]
Size range |
291-313 amino acids |
Related rules |
None |
Fusion |
Nter: <Unknown>; Cter: None |
Comments |
The ribosomal protein S6-modifying function does not apply to all RimK family members since some bacteria do not possess a rpsF gene in their genome or the C-terminal sequence of RpsF is not conserved or does not end with a glutamate residue. |