HAMAP rule MF_01570
General rule information
[?]
| PURL | https://purl.expasy.org/hamap/rule/MF_01570 |
| Accession | MF_01570 |
| Dates | 21-AUG-2006 (Created)
03-SEP-2024 (Last updated, Version 15) |
| Name | Pro_tRNA_synth_type2 |
| Scope(s) |
Bacteria Alphaproteobacteria Epsilonproteobacteria |
| Template(s) | Q6N5P6; [ Recover all ] |
| Triggered by |
HAMAP; MF_01570 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | SYP |
| Protein name | RecName: Full=Proline--tRNA ligase; EC=6.1.1.15; AltName: Full=Prolyl-tRNA synthetase; Short=ProRS; |
| Gene name | Name=proS; |
Comments
[?]
| FUNCTION | Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). |
| CATALYTIC ACTIVITY | Reaction=tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate; Xref=Rhea:RHEA:14305, Rhea:RHEA-COMP:9700, Rhea:RHEA- COMP:9702, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:60039, ChEBI:CHEBI:78442, ChEBI:CHEBI:78532, ChEBI:CHEBI:456215; EC=6.1.1.15; |
| SUBUNIT | Homodimer. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 2 subfamily. |
Keywords
[?]
Gene Ontology
[?]
| GO:0005524; Molecular function:ATP binding |
| GO:0004827; Molecular function:proline-tRNA ligase activity |
| GO:0006433; Biological process:prolyl-tRNA aminoacylation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
[?]
| PROSITE | PS50862; AA_TRNA_LIGASE_II; 1; |
| Pfam | PF03129; HGTP_anticodon; 1; |
| Pfam | PF00587; tRNA-synt_2b; 1; |
| PRINTS | PR01046; TRNASYNTHPRO; 1; |
| NCBIfam | TIGR00409; ProS_fam_II; 1; |
Features
[?]
Additional information
[?]
| Size range | 422-464 amino acids |
| Related rules |
MF_01569 MF_01571 |
| Fusion | Nter: None Cter: None |