HAMAP rule MF_01571
General rule information
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Accession | MF_01571 |
Dates | 22-AUG-2006 (Created) 19-NOV-2019 (Last updated, Version 16) |
Name | Pro_tRNA_synth_type3 |
Scope | Bacteria
Archaea |
Templates | Q5SM28 (SYP_THET8); Q58635 (SYP_METJA); O26708 (SYP_METTH); O51363 (SYP_BORBU); Q9L4Q8 (SYP_ACESD); Q9RUW4 (SYP_DEIRA): [Recover all] |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). |
Catalytic activity | RHEA:14305: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
EC 6.1.1.15 |
Subunit | Homodimer. |
Subcellular location | Cytoplasm. |
Domain | Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension. |
Similarity | Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily. |
Keywords
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Gene Ontology
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GO:0005524; Molecular function: ATP binding.
GO:0004827; Molecular function: proline-tRNA ligase activity.
GO:0006433; Biological process: prolyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
GO:0004827; Molecular function: proline-tRNA ligase activity.
GO:0006433; Biological process: prolyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.
Cross-references
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PROSITE | PS50862; AA_TRNA_LIGASE_II; 1; |
Pfam | PF03129; HGTP_anticodon; 1; |
PF00587; tRNA-synt_2b; 1; | |
PRINTS | PR01046; TRNASYNTHPRO; 1; |
TIGRFAMs | TIGR00408; ProS_fam_I; 1; |
Additional information
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Size range | 455-537 amino acids |
Related rules | MF_01569 (SYP); MF_01570 (SYP) |
Fusion | None |
Comments | Some species have a second copy of proS in another subfamily (MF_01569). |