HAMAP rule MF_01571

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01571
Accession	MF_01571
Dates	22-AUG-2006 (Created) 03-SEP-2024 (Last updated, Version 19)
Name	Pro_tRNA_synth_type3
Scope(s)	Bacteria Archaea
Template(s)	Q5SM28; Q58635; O26708; O51363; Q9L4Q8; Q9RUW4; [ Recover all ]
Triggered by	HAMAP; MF_01571 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SYP
Protein name	RecName: Full=Proline--tRNA ligase; EC=6.1.1.15; AltName: Full=Prolyl-tRNA synthetase; Short=ProRS;
Gene name	Name=proS;

Comments [?]

FUNCTION	Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
CATALYTIC ACTIVITY	Reaction=tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate; Xref=Rhea:RHEA:14305, Rhea:RHEA-COMP:9700, Rhea:RHEA- COMP:9702, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:60039, ChEBI:CHEBI:78442, ChEBI:CHEBI:78532, ChEBI:CHEBI:456215; EC=6.1.1.15;
SUBUNIT	Homodimer.
SUBCELLULAR LOCATION	Cytoplasm.
DOMAIN	Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
SIMILARITY	Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.

Keywords [?]

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding

GO:0004827; Molecular function:proline-tRNA ligase activity

GO:0006433; Biological process:prolyl-tRNA aminoacylation

GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Features [?]

Additional information [?]

Size range	455-537 amino acids
Related rules	MF_01569 MF_01570
Fusion	Nter: None Cter: None
Comments	Some species have a second copy of proS in another subfamily (MF_01569).