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Annotation rule MF_01571
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General rule information [?]

Accession MF_01571
Dates 22-AUG-2006 (Created)
19-NOV-2019 (Last updated, Version 16)
Name Pro_tRNA_synth_type3
Scope
Bacteria
Archaea
Templates Q5SM28 (SYP_THET8); Q58635 (SYP_METJA); O26708 (SYP_METTH); O51363 (SYP_BORBU); Q9L4Q8 (SYP_ACESD); Q9RUW4 (SYP_DEIRA): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
SYP
Protein name
RecName: Full=Proline--tRNA ligase;
EC 6.1.1.15;
AltName: Full=Prolyl-tRNA synthetase;
Short=ProRS;
Gene name
proS

Comments [?]

Function Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Catalytic activity RHEA:14305: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)
EC 6.1.1.15
Subunit Homodimer.
Subcellular location Cytoplasm.
Domain Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Similarity Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.

Keywords [?]


Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004827; Molecular function: proline-tRNA ligase activity.
GO:0006433; Biological process: prolyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS50862; AA_TRNA_LIGASE_II; 1;
Pfam PF03129; HGTP_anticodon; 1;
PF00587; tRNA-synt_2b; 1;
PRINTS PR01046; TRNASYNTHPRO; 1;
TIGRFAMs TIGR00408; ProS_fam_I; 1;

Additional information [?]

Size range 455-537 amino acids
Related rules MF_01569 (SYP); MF_01570 (SYP)
Fusion None
Comments Some species have a second copy of proS in another subfamily (MF_01569).