HAMAP rule MF_01571

General rule information [?]

Accession	MF_01571
Dates	22-AUG-2006 (Created) 19-NOV-2019 (Last updated, Version 16)

Name	Pro_tRNA_synth_type3

Scope

Bacteria

Archaea

Templates

Q5SM28 (SYP_THET8); Q58635 (SYP_METJA); O26708 (SYP_METTH); O51363 (SYP_BORBU); Q9L4Q8 (SYP_ACESD); Q9RUW4 (SYP_DEIRA): [Recover all]

Triggered by

HAMAP; MF_01571 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

SYP

Protein name

RecName:		Full=Proline--tRNA ligase;
		EC 6.1.1.15;
AltName:		Full=Prolyl-tRNA synthetase;
		Short=ProRS;

Gene name

proS

Comments [?]

Function	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).
Catalytic activity	RHEA:14305: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro) EC 6.1.1.15
Subunit	Homodimer.
Subcellular location	Cytoplasm.
Domain	Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.
Similarity	Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.

Keywords [?]

Cytoplasm
Aminoacyl-tRNA synthetase
ATP-binding
Ligase
Nucleotide-binding
Protein biosynthesis

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0004827; Molecular function: proline-tRNA ligase activity.
GO:0006433; Biological process: prolyl-tRNA aminoacylation.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE	PS50862; AA_TRNA_LIGASE_II; 1;
Pfam	PF03129; HGTP_anticodon; 1;
	PF00587; tRNA-synt_2b; 1;
PRINTS	PR01046; TRNASYNTHPRO; 1;
TIGRFAMs	TIGR00408; ProS_fam_I; 1;

Additional information [?]

Size range	455-537 amino acids
Related rules	MF_01569 (SYP); MF_01570 (SYP)
Fusion	None
Comments	Some species have a second copy of proS in another subfamily (MF_01569).

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