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HAMAP rule MF_01573

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General rule information [?]

Accession MF_01573
Dates 31-OCT-2006 (Created)
1-JUN-2023 (Last updated, Version 15)
Name Pyl_tRNA_synth
Scope(s) Archaea
Template(s) Q6WRH6 (PYLS_METBA); Q46E77 (PYLS_METBF); [ Recover all ]
Triggered by HAMAP; MF_01573 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier PYLS
Protein name RecName: Full=Pyrrolysine--tRNA ligase;
AltName: Full=Pyrrolysyl-tRNA synthetase;
Gene name Name=pylS;

Comments [?]

FUNCTIONCatalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG.
CATALYTIC ACTIVITY Reaction=ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L- pyrrolysyl-tRNA(Pyl); Xref=Rhea:RHEA:19277, Rhea:RHEA-COMP:9720, Rhea:RHEA-COMP:9721, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58499, ChEBI:CHEBI:78442, ChEBI:CHEBI:78556, ChEBI:CHEBI:456215; EC=;
SIMILARITYBelongs to the class-II aminoacyl-tRNA synthetase family.

Keywords [?]

Gene Ontology [?]

GO:0004812; Molecular function:aminoacyl-tRNA ligase activity
GO:0005524; Molecular function:ATP binding
GO:0006418; Biological process:tRNA aminoacylation for protein translation
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF00587; tRNA-synt_2b; 1;
NCBIfam TIGR02367; PylS_Cterm; 1;
NCBIfam TIGR03912; PylS_Nterm; 1;

Features [?]

Additional information [?]

Size range 404-478 amino acids
Related rules None
Fusion Nter: None Cter: None

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