HAMAP rule MF_01573
General rule information
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| Accession | MF_01573 |
| Dates | 31-OCT-2006 (Created)
3-SEP-2024 (Last updated, Version 16) |
| Name | Pyl_tRNA_synth |
| Scope(s) |
Archaea Methanosarcinales |
| Template(s) | Q6WRH6 (PYLS_METBA); Q46E77 (PYLS_METBF); [ Recover all ] |
| Triggered by |
HAMAP; MF_01573 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | PYLS |
| Protein name | RecName: Full=Pyrrolysine--tRNA ligase; EC=6.1.1.26; AltName: Full=Pyrrolysyl-tRNA synthetase; Short=PylRS; |
| Gene name | Name=pylS; |
Comments
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| FUNCTION | Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG. |
| CATALYTIC ACTIVITY | Reaction=tRNA(Pyl) + L-pyrrolysine + ATP = L-pyrrolysyl-tRNA(Pyl) + AMP + diphosphate; Xref=Rhea:RHEA:19277, Rhea:RHEA-COMP:9720, Rhea:RHEA-COMP:9721, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58499, ChEBI:CHEBI:78442, ChEBI:CHEBI:78556, ChEBI:CHEBI:456215; EC=6.1.1.26; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the class-II aminoacyl-tRNA synthetase family. |
Keywords
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Gene Ontology
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| GO:0004812; Molecular function:aminoacyl-tRNA ligase activity |
| GO:0005524; Molecular function:ATP binding |
| GO:0006418; Biological process:tRNA aminoacylation for protein translation |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS50862; AA_TRNA_LIGASE_II; 1; |
| Pfam | PF00587; tRNA-synt_2b; 1; |
| NCBIfam | TIGR02367; PylS_Cterm; 1; |
| NCBIfam | TIGR03912; PylS_Nterm; 1; |
Features
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Additional information
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| Size range | 404-478 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |