HAMAP rule MF_01573
General rule information
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Accession | MF_01573 |
Dates | 31-OCT-2006 (Created)
1-JUN-2023 (Last updated, Version 15) |
Name | Pyl_tRNA_synth |
Scope(s) |
Archaea Methanosarcinales |
Template(s) | Q6WRH6 (PYLS_METBA); Q46E77 (PYLS_METBF); [ Recover all ] |
Triggered by |
HAMAP; MF_01573 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | PYLS |
Protein name | RecName: Full=Pyrrolysine--tRNA ligase; EC=6.1.1.26; AltName: Full=Pyrrolysyl-tRNA synthetase; Short=PylRS; |
Gene name | Name=pylS; |
Comments
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FUNCTION | Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG. |
CATALYTIC ACTIVITY | Reaction=ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L- pyrrolysyl-tRNA(Pyl); Xref=Rhea:RHEA:19277, Rhea:RHEA-COMP:9720, Rhea:RHEA-COMP:9721, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58499, ChEBI:CHEBI:78442, ChEBI:CHEBI:78556, ChEBI:CHEBI:456215; EC=6.1.1.26; |
SUBCELLULAR LOCATION | Cytoplasm. |
SIMILARITY | Belongs to the class-II aminoacyl-tRNA synthetase family. |
Keywords
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Gene Ontology
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GO:0004812; Molecular function:aminoacyl-tRNA ligase activity |
GO:0005524; Molecular function:ATP binding |
GO:0006418; Biological process:tRNA aminoacylation for protein translation |
GO:0005737; Cellular component:cytoplasm |
Cross-references
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PROSITE | PS50862; AA_TRNA_LIGASE_II; 1; |
Pfam | PF00587; tRNA-synt_2b; 1; |
NCBIfam | TIGR02367; PylS_Cterm; 1; |
NCBIfam | TIGR03912; PylS_Nterm; 1; |
Features
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Additional information
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Size range | 404-478 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |