Due to maintenance work, this service will be unavailable from
Mon Nov 11 17:30 until
Tue Nov 12 09:00
CET.
Apologies for the inconvenience.
HAMAP rule MF_01574
General rule information
[?]
| Accession | MF_01574 |
| Dates | 2-NOV-2006 (Created)
1-JUN-2023 (Last updated, Version 17) |
| Name | LacG |
| Scope(s) |
Bacteria Bacillota Fusobacteriota |
| Template(s) | C7N8L9 (LACG_LEPBD); P11546 (LACG_LACLL); P11175 (LACG_STAAU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01574 (Get profile general information and statistics) |
Propagated annotation
[?]
Identifier, protein and gene names
[?]
| Identifier | LACG |
| Protein name | RecName: Full=6-phospho-beta-galactosidase; EC=3.2.1.85; AltName: Full=Beta-D-phosphogalactoside galactohydrolase; Short=PGALase; AltName: Full=P-beta-Gal; Short=PBG; |
| Gene name | Name=lacG; |
Comments
[?]
| CATALYTIC ACTIVITY | Reaction=a 6-phospho-beta-D-galactoside + H2O = an alcohol + D- galactose 6-phosphate; Xref=Rhea:RHEA:24568, ChEBI:CHEBI:15377, ChEBI:CHEBI:30879, ChEBI:CHEBI:58534, ChEBI:CHEBI:91004; EC=3.2.1.85; |
| PATHWAY | Carbohydrate metabolism; lactose degradation; D-galactose 6- phosphate and beta-D-glucose from lactose 6-phosphate: step 1/1. |
| SIMILARITY | Belongs to the glycosyl hydrolase 1 family. |
Keywords
[?]
Gene Ontology
[?]
| GO:0033920; Molecular function:6-phospho-beta-galactosidase activity |
| GO:0005990; Biological process:lactose catabolic process |
Cross-references
[?]
| PROSITE | PS00572; GLYCOSYL_HYDROL_F1_1; 1; |
| PROSITE | PS00653; GLYCOSYL_HYDROL_F1_2; 1; |
| Pfam | PF00232; Glyco_hydro_1; 1; |
| PRINTS | PR00131; GLHYDRLASE1; 1; |
| NCBIfam | TIGR01233; LacG; 1; |
Features
[?]
| From: LACG_LACLL (P11546) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 160 | 160 | /note="Proton donor" | E | ||||||||
| ACT_SITE | 375 | 375 | /note="Nucleophile" | E | ||||||||
| BINDING | 19 | 19 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
Q | ||||||||
| BINDING | 116 | 116 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
H | ||||||||
| BINDING | 159 | 159 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
N | ||||||||
| BINDING | 160 | 160 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
E | ||||||||
| BINDING | 297 | 297 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
[ND] | ||||||||
| BINDING | 428 | 428 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
[ST] | ||||||||
| BINDING | 429 | 429 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
W | ||||||||
| BINDING | 435 | 435 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
K | ||||||||
| BINDING | 437 | 437 | /ligand="D-galactose 6-phosphate" /ligand_id="ChEBI:CHEBI:91004" |
Y | ||||||||
Additional information
[?]
| Size range | 468-474 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |