HAMAP rule MF_01582

General rule information [?]

Accession	MF_01582
Dates	4-OCT-2007 (Created) 26-JAN-2023 (Last updated, Version 22)
Name	Ser_Thr_transp_SstT
Scope(s)	Bacteria Bifidobacteriales Bacillota Pseudomonadota
Template(s)	P0AGE4 (SSTT_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01582 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	SSTT
Protein name	RecName: Full=Serine/threonine transporter SstT; AltName: Full=Na(+)/serine-threonine symporter;
Gene name	Name=sstT;

Comments [?]

FUNCTION	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
CATALYTIC ACTIVITY	Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29577;
CATALYTIC ACTIVITY	Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70001;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATION	Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATION	Cell inner membrane; Multi-pass membrane protein.
end case
SIMILARITY	Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.

Keywords [?]

Amino-acid transport
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Symport
Transmembrane
Transport
Transmembrane helix

Gene Ontology [?]

GO:0015171; Molecular function:amino acid transmembrane transporter activity

GO:0015293; Molecular function:symporter activity

GO:0006865; Biological process:amino acid transport

GO:0005886; Cellular component:plasma membrane

Cross-references [?]

Features [?]

From: SSTT_ECOLI (P0AGE4)
Key	From	To	Description	Tag	Condition	FTGroup
case <OC:Escherichia> or <OC:Shigella>
INIT_MET	1	1	/note="Removed"		M
TOPO_DOM	2	15	/note="Cytoplasmic"
TRANSMEM	16	36	/note="Helical"
TOPO_DOM	37	45	/note="Periplasmic"
TRANSMEM	46	66	/note="Helical"
TOPO_DOM	67	83	/note="Cytoplasmic"
TRANSMEM	84	104	/note="Helical"
TOPO_DOM	105	142	/note="Periplasmic"
TRANSMEM	143	163	/note="Helical"
TOPO_DOM	164	179	/note="Cytoplasmic"
TRANSMEM	180	200	/note="Helical"
TOPO_DOM	201	217	/note="Periplasmic"
TRANSMEM	218	238	/note="Helical"
TOPO_DOM	239	299	/note="Cytoplasmic"
TRANSMEM	300	320	/note="Helical"
TOPO_DOM	321	331	/note="Periplasmic"
TRANSMEM	332	352	/note="Helical"
TOPO_DOM	353	Cter	/note="Cytoplasmic"
end case

Additional information [?]