HAMAP rule MF_01582
General rule information
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| Accession | MF_01582 |
| Dates | 4-OCT-2007 (Created) 26-JAN-2023 (Last updated, Version 22) |
| Name | Ser_Thr_transp_SstT |
| Scope | Bacteria; Bifidobacteriales
Bacteria; Bacillota
Bacteria; Pseudomonadota |
| Template | P0AGE4 (SSTT_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). |
| Catalytic activity | RHEA:29575: L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out)
PhysiologicalDirection=right-to-left (RHEA:29577) |
| RHEA:69999: L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out)
PhysiologicalDirection=right-to-left (RHEA:70001) |
case not defined <Property:Membrane> or <Property:Membrane=1>
| Subcellular location | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2>
| Subcellular location | Cell inner membrane; Multi-pass membrane protein. |
end case
| Similarity | Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. |
Keywords
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case defined <Property:Membrane> and <Property:Membrane=2>
end case
Gene Ontology
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GO:0015171; Molecular function: amino acid transmembrane transporter activity.
GO:0015293; Molecular function: symporter activity.
GO:0006865; Biological process: amino acid transport.
GO:0005886; Cellular component: plasma membrane.
GO:0015293; Molecular function: symporter activity.
GO:0006865; Biological process: amino acid transport.
GO:0005886; Cellular component: plasma membrane.
Cross-references
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| PROSITE | PS00713; NA_DICARBOXYL_SYMP_1; 1; |
| PS00714; NA_DICARBOXYL_SYMP_2; 1; | |
| Pfam | PF00375; SDF; 1; |
| PRINTS | PR00173; EDTRNSPORT; 1; |
Computed features
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case not <OC:Escherichia> and not <OC:Shigella>
| General | Transmembrane; -; 8-10; trigger=yes; |
end case
Features
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case <OC:Escherichia> or <OC:Shigella>
| From: SSTT_ECOLI (P0AGE4) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| INIT_MET | 1 | 1 | Removed | M | ||||||||
| TOPO_DOM | 2 | 15 | Cytoplasmic | |||||||||
| TRANSMEM | 16 | 36 | Helical | |||||||||
| TOPO_DOM | 37 | 45 | Periplasmic | |||||||||
| TRANSMEM | 46 | 66 | Helical | |||||||||
| TOPO_DOM | 67 | 83 | Cytoplasmic | |||||||||
| TRANSMEM | 84 | 104 | Helical | |||||||||
| TOPO_DOM | 105 | 142 | Periplasmic | |||||||||
| TRANSMEM | 143 | 163 | Helical | |||||||||
| TOPO_DOM | 164 | 179 | Cytoplasmic | |||||||||
| TRANSMEM | 180 | 200 | Helical | |||||||||
| TOPO_DOM | 201 | 217 | Periplasmic | |||||||||
| TRANSMEM | 218 | 238 | Helical | |||||||||
| TOPO_DOM | 239 | 299 | Cytoplasmic | |||||||||
| TRANSMEM | 300 | 320 | Helical | |||||||||
| TOPO_DOM | 321 | 331 | Periplasmic | |||||||||
| TRANSMEM | 332 | 352 | Helical | |||||||||
| TOPO_DOM | 353 | Cter | Cytoplasmic | |||||||||
end case
Additional information
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| Size range | 360-434 amino acids |
| Related rules | None |
| Fusion | None |