HAMAP rule MF_01582
General rule information
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Accession | MF_01582 |
Dates | 4-OCT-2007 (Created)
26-JAN-2023 (Last updated, Version 22) |
Name | Ser_Thr_transp_SstT |
Scope(s) |
Bacteria Bifidobacteriales Bacillota Pseudomonadota |
Template(s) | P0AGE4 (SSTT_ECOLI); [ Recover all ] |
Triggered by |
HAMAP; MF_01582 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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Identifier | SSTT |
Protein name | RecName: Full=Serine/threonine transporter SstT; AltName: Full=Na(+)/serine-threonine symporter; |
Gene name | Name=sstT; |
Comments
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FUNCTION | Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system). |
CATALYTIC ACTIVITY | Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29577; |
CATALYTIC ACTIVITY | Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70001; |
case not defined <Property:Membrane> or <Property:Membrane=1> | |
SUBCELLULAR LOCATION | Cell membrane; Multi-pass membrane protein. |
else case <Property:Membrane=2> | |
SUBCELLULAR LOCATION | Cell inner membrane; Multi-pass membrane protein. |
end case | |
SIMILARITY | Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. |
Keywords
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Amino-acid transport | |
Cell membrane | |
case defined <Property:Membrane> and <Property:Membrane=2> | |
Cell inner membrane | |
end case | |
Membrane | |
Symport | |
Transmembrane | |
Transport | |
Transmembrane helix |
Gene Ontology
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GO:0015171; Molecular function:amino acid transmembrane transporter activity |
GO:0015293; Molecular function:symporter activity |
GO:0006865; Biological process:amino acid transport |
GO:0005886; Cellular component:plasma membrane |
Cross-references
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PROSITE | PS00713; NA_DICARBOXYL_SYMP_1; 1; |
PROSITE | PS00714; NA_DICARBOXYL_SYMP_2; 1; |
Pfam | PF00375; SDF; 1; |
PRINTS | PR00173; EDTRNSPORT; 1; |
General | Transmembrane; -; 8-10; |
Features
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From: SSTT_ECOLI (P0AGE4) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
case <OC:Escherichia> or <OC:Shigella> | ||||||||||||
INIT_MET | 1 | 1 | /note="Removed" | M | ||||||||
TOPO_DOM | 2 | 15 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 16 | 36 | /note="Helical" | |||||||||
TOPO_DOM | 37 | 45 | /note="Periplasmic" | |||||||||
TRANSMEM | 46 | 66 | /note="Helical" | |||||||||
TOPO_DOM | 67 | 83 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 84 | 104 | /note="Helical" | |||||||||
TOPO_DOM | 105 | 142 | /note="Periplasmic" | |||||||||
TRANSMEM | 143 | 163 | /note="Helical" | |||||||||
TOPO_DOM | 164 | 179 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 180 | 200 | /note="Helical" | |||||||||
TOPO_DOM | 201 | 217 | /note="Periplasmic" | |||||||||
TRANSMEM | 218 | 238 | /note="Helical" | |||||||||
TOPO_DOM | 239 | 299 | /note="Cytoplasmic" | |||||||||
TRANSMEM | 300 | 320 | /note="Helical" | |||||||||
TOPO_DOM | 321 | 331 | /note="Periplasmic" | |||||||||
TRANSMEM | 332 | 352 | /note="Helical" | |||||||||
TOPO_DOM | 353 | Cter | /note="Cytoplasmic" | |||||||||
end case |
Additional information
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Size range | 360-434 amino acids |
Related rules |
None |
Fusion | Nter: None Cter: None |