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HAMAP rule MF_01582

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General rule information [?]

Accession MF_01582
Dates 4-OCT-2007 (Created)
26-JAN-2023 (Last updated, Version 22)
Name Ser_Thr_transp_SstT
Scope(s) Bacteria
Bifidobacteriales
Bacillota
Pseudomonadota
Template(s) P0AGE4 (SSTT_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01582 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier SSTT
Protein name RecName: Full=Serine/threonine transporter SstT;
AltName: Full=Na(+)/serine-threonine symporter;
Gene name Name=sstT;

Comments [?]

FUNCTIONInvolved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system).
CATALYTIC ACTIVITY Reaction=L-serine(in) + Na(+)(in) = L-serine(out) + Na(+)(out); Xref=Rhea:RHEA:29575, ChEBI:CHEBI:29101, ChEBI:CHEBI:33384; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:29577;
CATALYTIC ACTIVITY Reaction=L-threonine(in) + Na(+)(in) = L-threonine(out) + Na(+)(out); Xref=Rhea:RHEA:69999, ChEBI:CHEBI:29101, ChEBI:CHEBI:57926; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:70001;
case not defined <Property:Membrane> or <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
end case
SIMILARITYBelongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.

Keywords [?]

Amino-acid transport
Cell membrane
case defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case
Membrane
Symport
Transmembrane
Transport
Transmembrane helix

Gene Ontology [?]

GO:0015171; Molecular function:amino acid transmembrane transporter activity
GO:0015293; Molecular function:symporter activity
GO:0006865; Biological process:amino acid transport
GO:0005886; Cellular component:plasma membrane

Cross-references [?]

PROSITE PS00713; NA_DICARBOXYL_SYMP_1; 1;
PROSITE PS00714; NA_DICARBOXYL_SYMP_2; 1;
Pfam PF00375; SDF; 1;
PRINTS PR00173; EDTRNSPORT; 1;
General Transmembrane; -; 8-10;

Features [?]

From: SSTT_ECOLI (P0AGE4)
Key From To Description Tag Condition FTGroup
case <OC:Escherichia> or <OC:Shigella>
INIT_MET 1 1 /note="Removed" M
TOPO_DOM 2 15 /note="Cytoplasmic"
TRANSMEM 16 36 /note="Helical"
TOPO_DOM 37 45 /note="Periplasmic"
TRANSMEM 46 66 /note="Helical"
TOPO_DOM 67 83 /note="Cytoplasmic"
TRANSMEM 84 104 /note="Helical"
TOPO_DOM 105 142 /note="Periplasmic"
TRANSMEM 143 163 /note="Helical"
TOPO_DOM 164 179 /note="Cytoplasmic"
TRANSMEM 180 200 /note="Helical"
TOPO_DOM 201 217 /note="Periplasmic"
TRANSMEM 218 238 /note="Helical"
TOPO_DOM 239 299 /note="Cytoplasmic"
TRANSMEM 300 320 /note="Helical"
TOPO_DOM 321 331 /note="Periplasmic"
TRANSMEM 332 352 /note="Helical"
TOPO_DOM 353 Cter /note="Cytoplasmic"
end case

Additional information [?]

Size range 360-434 amino acids
Related rules None
Fusion Nter: None Cter: None



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