HAMAP rule MF_01590

General rule information [?]

PURL	https://purl.expasy.org/hamap/rule/MF_01590
Accession	MF_01590
Dates	22-NOV-2007 (Created) 03-SEP-2024 (Last updated, Version 17)
Name	tRNA_carboxymethyltr_CmoB
Scope(s)	Bacteria Oscillatoriales Pseudomonadota
Template(s)	P76291; Q8ZNV1; [ Recover all ]
Triggered by	HAMAP; MF_01590 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	CMOB
Protein name	RecName: Full=tRNA U34 carboxymethyltransferase; EC=2.5.1.-;
Gene name	Name=cmoB;

Comments [?]

FUNCTION	Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
CATALYTIC ACTIVITY	Reaction=carboxy-S-adenosyl-L-methionine + 5-hydroxyuridine(34) in tRNA = 5-carboxymethoxyuridine(34) in tRNA + S-adenosyl-L-homocysteine + H(+); Xref=Rhea:RHEA:52848, Rhea:RHEA-COMP:13381, Rhea:RHEA- COMP:13383, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:134278, ChEBI:CHEBI:136877, ChEBI:CHEBI:136879;
case <OC:Pseudomonadota>
SUBUNIT	Homotetramer.
end case
SIMILARITY	Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.

Keywords [?]

Gene Ontology [?]

GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups

GO:0006400; Biological process:tRNA modification

Cross-references [?]

Pfam	PF08003; Methyltransf_9; 1;
NCBIfam	TIGR00452; TIGR00452; 1;

Features [?]

From: CMOB_ECOLI (P76291)

Key

From

Description

Tag

Condition

FTGroup

BINDING

152

154