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Annotation rule MF_01590
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General rule information [?]

Accession MF_01590
Dates 22-NOV-2007 (Created)
19-NOV-2019 (Last updated, Version 10)
Name tRNA_carboxymethyltr_CmoB
Bacteria; Oscillatoriales
Bacteria; Proteobacteria
Templates P76291 (CMOB_ECOLI); Q8ZNV1 (CMOB_SALTY): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=tRNA U34 carboxymethyltransferase;
EC 2.5.1.-;
Gene name

Comments [?]

Function Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
Catalytic activity RHEA:52848: 5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine
case <OC:Proteobacteria>
Subunit Homotetramer.
end case
Similarity Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.

Keywords [?]

Gene Ontology [?]

GO:0016765; Molecular function: transferase activity, transferring alkyl or aryl (other than methyl) groups.
GO:0006400; Biological process: tRNA modification.

Cross-references [?]

Pfam PF08003; Methyltransf_9; 1;
TIGRFAMs TIGR00452; TIGR00452; 1;

Features [?]

From: CMOB_ECOLI (P76291)
Key     From     To       Description   Tag   Condition   FTGroup
REGION (Optional)     152     154       Carboxy-S-adenosyl-L-methionine binding     [DE]-P-[TS]  
REGION (Optional)     181     182       Carboxy-S-adenosyl-L-methionine binding     [IVLM]-[ED]  
BINDING (Optional)     91     91       Carboxy-S-adenosyl-L-methionine     K  
BINDING (Optional)     105     105       Carboxy-S-adenosyl-L-methionine     W  
BINDING (Optional)     110     110       Carboxy-S-adenosyl-L-methionine     K  
BINDING (Optional)     130     130       Carboxy-S-adenosyl-L-methionine; via carbonyl oxygen     G  
BINDING (Optional)     196     196       Carboxy-S-adenosyl-L-methionine; via carbonyl oxygen     M  
BINDING (Optional)     200     200       Carboxy-S-adenosyl-L-methionine     Y  
BINDING (Optional)     315     315       Carboxy-S-adenosyl-L-methionine     R  

Additional information [?]

Size range 261-363 amino acids
Related rules None
Fusion None