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HAMAP rule MF_01590

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General rule information [?]

Accession MF_01590
Dates 22-NOV-2007 (Created)
1-JUN-2023 (Last updated, Version 15)
Name tRNA_carboxymethyltr_CmoB
Scope(s) Bacteria
Template(s) P76291 (CMOB_ECOLI); Q8ZNV1 (CMOB_SALTY); [ Recover all ]
Triggered by HAMAP; MF_01590 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier CMOB
Protein name RecName: Full=tRNA U34 carboxymethyltransferase;
Gene name Name=cmoB;

Comments [?]

FUNCTIONCatalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.
CATALYTIC ACTIVITY Reaction=5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:52848, Rhea:RHEA-COMP:13381, Rhea:RHEA- COMP:13383, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:134278, ChEBI:CHEBI:136877, ChEBI:CHEBI:136879;
case <OC:Pseudomonadota>
end case
SIMILARITYBelongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.

Keywords [?]

Gene Ontology [?]

GO:0016765; Molecular function:transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0006400; Biological process:tRNA modification

Cross-references [?]

Pfam PF08003; Methyltransf_9; 1;
NCBIfam TIGR00452; TIGR00452; 1;

Features [?]

From: CMOB_ECOLI (P76291)
Key From To Description Tag Condition FTGroup
BINDING 152 154 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 181 182 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 91 91 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 105 105 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 110 110 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 130 130 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 196 196 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 200 200 /ligand="carboxy-S-adenosyl-L-methionine"
BINDING 315 315 /ligand="carboxy-S-adenosyl-L-methionine"

Additional information [?]

Size range 261-363 amino acids
Related rules None
Fusion Nter: None Cter: None

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