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HAMAP rule MF_01593

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General rule information [?]

Accession MF_01593
Dates 19-DEC-2007 (Created)
18-OCT-2023 (Last updated, Version 13)
Name MtfA
Scope(s) Bacteria
Template(s) P76346 (MTFA_ECOLI); A6TB83 (MTFA_KLEP7); [ Recover all ]
Triggered by HAMAP; MF_01593 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MTFA
Protein name RecName: Full=Mlc titration factor A;
AltName: Full=Probable zinc metallopeptidase MtfA;
Gene name Name=mtfA;

Comments [?]

FUNCTIONInvolved in the modulation of the activity of the glucose- phosphotransferase system (glucose-PTS). Interacts with the transcriptional repressor Mlc, preventing its interaction with DNA and leading to the modulation of expression of genes regulated by Mlc, including ptsG, which encodes the PTS system glucose-specific EIICB component.
FUNCTIONShows zinc-dependent metallopeptidase activity.
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
SUBUNITInteracts with Mlc.
SIMILARITYBelongs to the MtfA family.

Keywords [?]

Gene Ontology [?]

GO:0004177; Molecular function:aminopeptidase activity
GO:0008237; Molecular function:metallopeptidase activity
GO:0008270; Molecular function:zinc ion binding
GO:0005737; Cellular component:cytoplasm

Cross-references [?]

Pfam PF06167; Peptidase_M90; 1;

Features [?]

From: MTFA_KLEP7 (A6TB83)
Key From To Description Tag Condition FTGroup
BINDING 111 111 /ligand="Zn(2+)"
BINDING 148 148 /ligand="Zn(2+)"
BINDING 152 152 /ligand="Zn(2+)"
BINDING 211 211 /ligand="Zn(2+)"

Additional information [?]

Size range 251-270 amino acids
Related rules None
Fusion Nter: None Cter: None

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