HAMAP rule MF_01593
General rule information
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| Accession | MF_01593 |
| Dates | 19-DEC-2007 (Created)
18-OCT-2023 (Last updated, Version 13) |
| Name | MtfA |
| Scope(s) |
Bacteria Enterobacterales |
| Template(s) | P76346 (MTFA_ECOLI); A6TB83 (MTFA_KLEP7); [ Recover all ] |
| Triggered by |
HAMAP; MF_01593 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MTFA |
| Protein name | RecName: Full=Mlc titration factor A; AltName: Full=Probable zinc metallopeptidase MtfA; EC=3.4.11.-; |
| Gene name | Name=mtfA; |
Comments
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| FUNCTION | Involved in the modulation of the activity of the glucose- phosphotransferase system (glucose-PTS). Interacts with the transcriptional repressor Mlc, preventing its interaction with DNA and leading to the modulation of expression of genes regulated by Mlc, including ptsG, which encodes the PTS system glucose-specific EIICB component. |
| FUNCTION | Shows zinc-dependent metallopeptidase activity. |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| SUBUNIT | Interacts with Mlc. |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the MtfA family. |
Keywords
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Gene Ontology
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| GO:0004177; Molecular function:aminopeptidase activity |
| GO:0008237; Molecular function:metallopeptidase activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| Pfam | PF06167; Peptidase_M90; 1; |
Features
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| From: MTFA_KLEP7 (A6TB83) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 111 | 111 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 148 | 148 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 152 | 152 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
H | ||||||||
| BINDING | 211 | 211 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
E | ||||||||
Additional information
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| Size range | 251-270 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |