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Annotation rule MF_01603
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General rule information [?]

Accession MF_01603
Dates 30-SEP-2004 (Created)
19-NOV-2019 (Last updated, Version 24)
Name HldE
Scope
Bacteria
Template P76658 (HLDE_ECOLI)
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
HLDE
Protein name
RecName: Full=Bifunctional protein HldE;
Includes:
RecName: Full=D-beta-D-heptose 7-phosphate kinase;
EC 2.7.1.167;
AltName: Full=D-beta-D-heptose 7-phosphotransferase;
AltName: Full=D-glycero-beta-D-manno-heptose-7-phosphate kinase;
Includes:
RecName: Full=D-beta-D-heptose 1-phosphate adenylyltransferase;
EC 2.7.7.70;
AltName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase;
Gene name
hldE

Comments [?]

Function Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.
Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.
Catalytic activity RHEA:27473: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)
EC 2.7.1.167
RHEA:27465: ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate
EC 2.7.7.70
Pathway Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.
Subunit Homodimer.
Similarity In the N-terminal section; belongs to the carbohydrate kinase PfkB family.
In the C-terminal section; belongs to the cytidylyltransferase family.

Keywords [?]

case <FT:5>
Acetylation
end case
ATP-binding
Carbohydrate metabolism
Kinase
Multifunctional enzyme
Nucleotide-binding
Nucleotidyltransferase
Transferase

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0033785; Molecular function: heptose 7-phosphate kinase activity.
GO:0033786; Molecular function: heptose-1-phosphate adenylyltransferase activity.
GO:0005975; Biological process: carbohydrate metabolic process.

Cross-references [?]

Pfam PF01467; CTP_transf_2; 1;
PF00294; PfkB; 1;
TIGRFAMs TIGR00125; Cyt_tran_rel; 1;
TIGR02198; RfaE_dom_I; 1;
TIGR02199; RfaE_dom_II; 1;
PROSITE PS00583; PFKB_KINASES_1; 1;
PS00584; PFKB_KINASES_2; 1;

Features [?]

From: HLDE_ECOLI (P76658)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND     195     198       ATP     N-x-x-E  
REGION     Nter     318       Ribokinase        
REGION     344     Cter       Cytidylyltransferase        
ACT_SITE     264     264             D  
case <OC:Escherichia> or <OC:Shigella>
MOD_RES     179     179       N6-acetyllysine     K  
end case

Additional information [?]

Size range 458-496 amino acids
Related rules None
Fusion None


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