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Annotation rule MF_01603 |
General rule information
[?]
Accession |
MF_01603 |
Dates |
30-SEP-2004 (Created) 19-NOV-2019 (Last updated, Version 24) |
Propagated annotation
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Identifier, protein and gene names
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Protein name |
RecName:
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Full=Bifunctional protein HldE;
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Includes:
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RecName:
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Full=D-beta-D-heptose 7-phosphate kinase;
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EC 2.7.1.167;
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AltName:
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Full=D-beta-D-heptose 7-phosphotransferase;
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AltName:
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Full=D-glycero-beta-D-manno-heptose-7-phosphate kinase;
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Includes:
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RecName:
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Full=D-beta-D-heptose 1-phosphate adenylyltransferase;
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EC 2.7.7.70;
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AltName:
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Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase;
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Function |
Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate. |
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Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. |
Catalytic activity |
RHEA:27473: ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)
EC 2.7.1.167
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RHEA:27465: ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate
EC 2.7.7.70
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Pathway |
Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4. |
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Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4. |
Subunit |
Homodimer. |
Similarity |
In the N-terminal section; belongs to the carbohydrate kinase PfkB family. |
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In the C-terminal section; belongs to the cytidylyltransferase family. |
case <FT:5>
end case
GO:0005524; Molecular function: ATP binding.
GO:0033785; Molecular function: heptose 7-phosphate kinase activity.
GO:0033786; Molecular function: heptose-1-phosphate adenylyltransferase activity.
GO:0005975; Biological process: carbohydrate metabolic process.
From: HLDE_ECOLI (P76658) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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NP_BIND
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195
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198
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ATP
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N-x-x-E
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REGION
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Nter
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318
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Ribokinase
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REGION
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344
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Cter
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Cytidylyltransferase
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ACT_SITE
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264
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264
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D
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case <OC:Escherichia> or <OC:Shigella>
MOD_RES
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179
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179
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N6-acetyllysine
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K
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end case
Additional information
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Size range |
458-496 amino acids |
Related rules |
None |
Fusion |
None |