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Annotation rule MF_01609
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General rule information [?]

Accession MF_01609
Dates 12-APR-2005 (Created)
27-OCT-2018 (Last updated, Version 23)
Name Glu_cys_ligase_2
Scope
Bacteria
Archaea
Templates D4GZN2 (GCS2_HALVD); P77213 (GCS2_ECOLI): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
GCS2
case <OC:Archaea>
Protein name
RecName: Full=Glutamate--cysteine ligase;
EC=6.3.2.2;
AltName: Full=Gamma-glutamylcysteine synthetase;
Short=Gamma-GCS;
Short=GCS;
Gene name
gshA
else
Protein name
RecName: Full=Putative glutamate--cysteine ligase 2;
EC=6.3.2.2;
AltName: Full=Gamma-glutamylcysteine synthetase 2;
Short=Gamma-GCS 2;
Short=GCS 2;
end case

Comments [?]

case <OC:Archaea>
Function Catalyzes the synthesis of gamma-glutamylcysteine (gamma-GC), the main low-molecular-weight thiol compound instead of glutathione in halophilic archaea.
else
Function ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.
end case
Catalytic activity Reaction=ATP + L-cysteine + L-glutamate = ADP + H(+) + L-gamma- glutamyl-L-cysteine + phosphate; Xref=Rhea:RHEA:13285, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:35235, ChEBI:CHEBI:43474, ChEBI:CHEBI:58173, ChEBI:CHEBI:456216; EC=6.3.2.2;.
case <OC:Enterobacterales>
Subunit Homodimer.
end case
Similarity Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily.

Keywords [?]

Ligase
ATP-binding
Nucleotide-binding

Gene Ontology [?]

case <OC:Archaea>
GO:0004357; Molecular function: glutamate-cysteine ligase activity.
else
GO:0016879; Molecular function: ligase activity, forming carbon-nitrogen bonds.
end case

Cross-references [?]

Pfam PF04107; GCS2; 1;
TIGRFAMs TIGR02050; GshA_cyan_rel; 1;

Additional information [?]

Size range 320-426 amino acids
Related rules None
Fusion Nter: None; Cter: <Unknown>, <Peptidase M20>


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