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Annotation rule MF_01610
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General rule information [?]

Accession MF_01610
Dates 12-APR-2005 (Created)
19-NOV-2019 (Last updated, Version 14)
Name MfnA_decarbox
Scope
Archaea
Templates Q60358 (MFNA_METJA); Q5JJ82 (MFNA_THEKO); O58679 (MFNA_PYRHO): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MFNA
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Protein name
RecName: Full=Probable L-tyrosine/L-aspartate decarboxylase;
Short=TDC/ADC;
EC 4.1.1.25;
EC 4.1.1.11;
else
Protein name
RecName: Full=Probable L-aspartate decarboxylase;
Short=ADC;
EC 4.1.1.11;
end case
Gene name
mfnA

Comments [?]

case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis.
Catalytic activity RHEA:14345: H(+) + L-tyrosine = CO2 + tyramine
EC 4.1.1.25
RHEA:19497: H(+) + L-aspartate = beta-alanine + CO2
EC 4.1.1.11
else
Function Catalyzes the decarboxylation of L-aspartate to produce beta-alanine.
Catalytic activity RHEA:19497: H(+) + L-aspartate = beta-alanine + CO2
EC 4.1.1.11
end case
Cofactor pyridoxal 5'-phosphate
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway Cofactor biosynthesis; methanofuran biosynthesis.
end case
Pathway Cofactor biosynthesis; coenzyme A biosynthesis.
Similarity Belongs to the group II decarboxylase family. MfnA subfamily.

Keywords [?]

Decarboxylase
Lyase
Pyridoxal phosphate

Gene Ontology [?]

GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0004068; Molecular function: aspartate 1-decarboxylase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0004837; Molecular function: tyrosine decarboxylase activity.
GO:2001120; Biological process: methanofuran biosynthetic process.
end case

Cross-references [?]

Pfam PF00282; Pyridoxal_deC; 1;
PROSITE PS00392; DDC_GAD_HDC_YDC; 1;
TIGRFAMs TIGR03812; tyr_de_CO2_Arch; 1;

Features [?]

From: MFNA_METJA (Q60358)
Key     From     To       Description   Tag   Condition   FTGroup
MOD_RES     245     245       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 325-410 amino acids
Related rules None
Fusion None
Comments In methanogens, the essential role of MfnA is to generate tyramine for methanofuran biosynthesis, but it can also supply the small amount of beta-alanine needed for coenzyme A production (see PubMed:24891443).


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