HAMAP rule MF_01610
General rule information
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| Accession | MF_01610 |
| Dates | 12-APR-2005 (Created)
1-JUN-2023 (Last updated, Version 15) |
| Name | MfnA_decarbox |
| Scope(s) |
Archaea |
| Template(s) | Q60358 (MFNA_METJA); Q5JJ82 (MFNA_THEKO); O58679 (MFNA_PYRHO); [ Recover all ] |
| Triggered by |
HAMAP; MF_01610 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MFNA |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| Protein name | RecName: Full=Probable L-tyrosine/L-aspartate decarboxylase; Short=TDC/ADC; EC=4.1.1.25; EC=4.1.1.11; |
| else | |
| Protein name | RecName: Full=Probable L-aspartate decarboxylase; Short=ADC; EC=4.1.1.11; |
| end case | |
| Gene name | Name=mfnA; |
Comments
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| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| FUNCTION | Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. |
| CATALYTIC ACTIVITY | Reaction=H(+) + L-tyrosine = CO2 + tyramine; Xref=Rhea:RHEA:14345, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:58315, ChEBI:CHEBI:327995; EC=4.1.1.25; |
| CATALYTIC ACTIVITY | Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11; |
| else | |
| FUNCTION | Catalyzes the decarboxylation of L-aspartate to produce beta- alanine. |
| CATALYTIC ACTIVITY | Reaction=H(+) + L-aspartate = beta-alanine + CO2; Xref=Rhea:RHEA:19497, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:29991, ChEBI:CHEBI:57966; EC=4.1.1.11; |
| end case | |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| PATHWAY | Cofactor biosynthesis; methanofuran biosynthesis. |
| end case | |
| PATHWAY | Cofactor biosynthesis; coenzyme A biosynthesis. |
| SIMILARITY | Belongs to the group II decarboxylase family. MfnA subfamily. |
Keywords
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Gene Ontology
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| GO:0030170; Molecular function:pyridoxal phosphate binding | |
| GO:0004068; Molecular function:aspartate 1-decarboxylase activity | |
| GO:0015937; Biological process:coenzyme A biosynthetic process | |
| case <OCellular component:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri> | |
| GO:0004837; Molecular function:tyrosine decarboxylase activity | |
| GO:2001120; Biological process:methanofuran biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF00282; Pyridoxal_deC; 1; |
| PROSITE | PS00392; DDC_GAD_HDC_YDC; 1; |
| NCBIfam | TIGR03812; tyr_de_CO2_Arch; 1; |
Features
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| From: MFNA_METJA (Q60358) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| MOD_RES | 245 | 245 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 325-410 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |
| Comments | In methanogens, the essential role of MfnA is to generate tyramine for methanofuran biosynthesis, but it can also supply the small amount of beta-alanine needed for coenzyme A production (see PubMed:24891443). |