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Annotation rule MF_01610 |
General rule information
[?]
Accession |
MF_01610 |
Dates |
12-APR-2005 (Created) 19-NOV-2019 (Last updated, Version 14) |
Propagated annotation
[?]
Identifier, protein and gene names
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case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
else
Protein name |
RecName:
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Full=Probable L-aspartate decarboxylase;
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Short=ADC;
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EC 4.1.1.11;
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end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Function |
Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis. |
Catalytic activity |
RHEA:14345: H(+) + L-tyrosine = CO2 + tyramine
EC 4.1.1.25
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RHEA:19497: H(+) + L-aspartate = beta-alanine + CO2
EC 4.1.1.11
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else
Function |
Catalyzes the decarboxylation of L-aspartate to produce beta-alanine. |
Catalytic activity |
RHEA:19497: H(+) + L-aspartate = beta-alanine + CO2
EC 4.1.1.11
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end case
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
Pathway |
Cofactor biosynthesis; methanofuran biosynthesis. |
end case
Pathway |
Cofactor biosynthesis; coenzyme A biosynthesis. |
Similarity |
Belongs to the group II decarboxylase family. MfnA subfamily. |
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0004068; Molecular function: aspartate 1-decarboxylase activity.
GO:0015937; Biological process: coenzyme A biosynthetic process.
case <OC:Methanobacteria> or <OC:Methanococci> or <OC:Methanomicrobia> or <OC:Methanopyri>
GO:0004837; Molecular function: tyrosine decarboxylase activity.
GO:2001120; Biological process: methanofuran biosynthetic process.
end case
From: MFNA_METJA (Q60358) |
Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
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MOD_RES
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245
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245
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N6-(pyridoxal phosphate)lysine
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K
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Additional information
[?]
Size range |
325-410 amino acids |
Related rules |
None |
Fusion |
None |
Comments |
In methanogens, the essential role of MfnA is to generate tyramine for methanofuran biosynthesis, but it can also supply the small amount of beta-alanine needed for coenzyme A production (see PubMed:24891443). |