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HAMAP rule MF_01614

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General rule information [?]

Accession MF_01614
Dates 1-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 19)
Name NamA
Scope(s) Bacteria
Bacillales
Eubacteriales
Template(s) P54550 (NAMA_BACSU); [ Recover all ]
Triggered by HAMAP; MF_01614 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier NAMA
Protein name RecName: Full=NADPH dehydrogenase;
                 EC=1.6.99.1;
Gene name Name=namA;

Comments [?]

FUNCTIONCatalyzes the reduction of the double bond of an array of alpha,beta-unsaturated aldehydes and ketones. It also reduces the nitro group of nitroester and nitroaromatic compounds. It could have a role in detoxification processes.
CATALYTIC ACTIVITY Reaction=A + H(+) + NADPH = AH2 + NADP(+); Xref=Rhea:RHEA:13149, ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.6.99.1;
COFACTOR Name=FMN; Xref=ChEBI:CHEBI:58210;
SUBUNITHomotetramer.
SIMILARITYBelongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.

Keywords [?]


Gene Ontology [?]

GO:0003959; Molecular function:NADPH dehydrogenase activity
GO:0010181; Molecular function:FMN binding
GO:0050661; Molecular function:NADP binding

Cross-references [?]

Pfam PF00724; Oxidored_FMN; 1;

Features [?]

From: NAMA_BACSU (P54550)
Key From To Description Tag Condition FTGroup
BINDING 23 26 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[SP]-P-M-C
BINDING 307 308 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
[AG]-R
BINDING 164 167 /ligand="substrate" H-x-x-H
BINDING 28 28 /ligand="substrate" Y
BINDING 60 60 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
A
BINDING 102 102 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
Q
BINDING 215 215 /ligand="FMN"
/ligand_id="ChEBI:CHEBI:58210"
R

Additional information [?]

Size range 337-346 amino acids
Related rules None
Fusion Nter: None Cter: None



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