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Annotation rule MF_01615
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General rule information [?]

Accession MF_01615
Dates 13-JUN-2005 (Created)
19-NOV-2019 (Last updated, Version 22)
Name PdxT
Scope
Bacteria
Archaea
Templates P37528 (PDXT_BACSU); Q9WYU3 (PDXT_THEMA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
PDXT
Protein name
RecName: Full=Pyridoxal 5'-phosphate synthase subunit PdxT;
EC 4.3.3.6;
AltName: Full=Pyridoxal 5'-phosphate synthase glutaminase subunit;
EC 3.5.1.2;
AltName: Full=Pdx2;
Gene name
pdxT

Comments [?]

Function Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.
Catalytic activity RHEA:31507: aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
EC 4.3.3.6
RHEA:15889: H2O + L-glutamine = L-glutamate + NH4(+)
EC 3.5.1.2
Pathway Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.
Subunit In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer.
Similarity Belongs to the glutaminase PdxT/SNO family.

Keywords [?]

Glutamine amidotransferase
Pyridoxal phosphate
Hydrolase
Lyase

Gene Ontology [?]

GO:0004359; Molecular function: glutaminase activity.
GO:0036381; Molecular function: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity.
GO:0006543; Biological process: glutamine catabolic process.
GO:0042823; Biological process: pyridoxal phosphate biosynthetic process.

Cross-references [?]

Pfam PF01174; SNO; 1;
PRINTS PR00096; GATASE; 1;
PROSITE PS01236; PDXT_SNO_1; 1;
PS51130; PDXT_SNO_2; 1;
TIGRFAMs TIGR03800; PLP_synth_Pdx2; 1;

Features [?]

From: PDXT_BACSU (P37528)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     47     49       L-glutamine binding     G-x-S  
REGION     134     135       L-glutamine binding     I-R  
ACT_SITE     79     79       Nucleophile     C  
ACT_SITE     170     170       Charge relay system     H  
ACT_SITE     172     172       Charge relay system     E  
BINDING     106     106       L-glutamine     R  

Additional information [?]

Size range 173-236 amino acids
Related rules None
Fusion None


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