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Annotation rule MF_01615 |
Accession | MF_01615 |
Dates | 13-JUN-2005 (Created) 19-NOV-2019 (Last updated, Version 22) |
Name | PdxT |
Scope | Bacteria
Archaea |
Templates | P37528 (PDXT_BACSU); Q9WYU3 (PDXT_THEMA): [Recover all] |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. |
Catalytic activity | RHEA:31507: aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = H(+) + 3 H2O + L-glutamate + phosphate + pyridoxal 5'-phosphate
EC 4.3.3.6 |
RHEA:15889: H2O + L-glutamine = L-glutamate + NH4(+)
EC 3.5.1.2 |
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Pathway | Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis. |
Subunit | In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. |
Similarity | Belongs to the glutaminase PdxT/SNO family. |
Pfam | PF01174; SNO; 1; |
PRINTS | PR00096; GATASE; 1; |
PROSITE | PS01236; PDXT_SNO_1; 1; |
PS51130; PDXT_SNO_2; 1; | |
TIGRFAMs | TIGR03800; PLP_synth_Pdx2; 1; |
From: PDXT_BACSU (P37528) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
REGION | 47 | 49 | L-glutamine binding | G-x-S | ||||||||
REGION | 134 | 135 | L-glutamine binding | I-R | ||||||||
ACT_SITE | 79 | 79 | Nucleophile | C | ||||||||
ACT_SITE | 170 | 170 | Charge relay system | H | ||||||||
ACT_SITE | 172 | 172 | Charge relay system | E | ||||||||
BINDING | 106 | 106 | L-glutamine | R |
Size range | 173-236 amino acids |
Related rules | None |
Fusion | None |