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HAMAP rule MF_01618

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General rule information [?]

Accession MF_01618
Dates 11-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 19)
Name FadI
Bacteria; Gammaproteobacteria
Template P76503 (FADI_ECOLI)

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=3-ketoacyl-CoA thiolase;
AltName: Full=ACSs;
AltName: Full=Acetyl-CoA acyltransferase;
AltName: Full=Acyl-CoA ligase;
AltName: Full=Beta-ketothiolase;
AltName: Full=Fatty acid oxidation complex subunit beta;
Gene name

Comments [?]

Function Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Catalytic activity RHEA:21564: acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA
Pathway Lipid metabolism; fatty acid beta-oxidation.
Subunit Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
Subcellular location Cytoplasm.
Similarity Belongs to the thiolase-like superfamily. Thiolase family.

Keywords [?]

Gene Ontology [?]

GO:0003988; Molecular function: acetyl-CoA C-acyltransferase activity.
GO:0006631; Biological process: fatty acid metabolic process.
GO:0016042; Biological process: lipid catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PS00737; THIOLASE_2; 1;
PS00099; THIOLASE_3; 1;
Pfam PF02803; Thiolase_C; 1;
PF00108; Thiolase_N; 1;
TIGRFAMs TIGR01930; AcCoA-C-Actrans; 1;
TIGR02446; FadI; 1;

Features [?]

From: FADI_ECOLI (P76503)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     99     99       Acyl-thioester intermediate     C  
ACT_SITE     392     392       Proton acceptor     H  
ACT_SITE     422     422       Proton acceptor     C  

Additional information [?]

Size range 435-442 amino acids
Related rules None
Fusion None