HAMAP rule MF_01618

Accession	MF_01618
Dates	11-NOV-2005 (Created) 19-NOV-2019 (Last updated, Version 19)

Name

FadI

Scope

Bacteria; Gammaproteobacteria

Template

P76503 (FADI_ECOLI)

Triggered by

HAMAP; MF_01618 (Get profile general information and statistics)

Identifier

FADI

Protein name

RecName: Full=3-ketoacyl-CoA thiolase; EC 2.3.1.16; AltName: Full=ACSs; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Acyl-CoA ligase; AltName: Full=Beta-ketothiolase; AltName: Full=Fatty acid oxidation complex subunit beta;

Gene name

fadI

Function	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Catalytic activity	RHEA:21564: acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA EC 2.3.1.16
Pathway	Lipid metabolism; fatty acid beta-oxidation.
Subunit	Heterotetramer of two alpha chains (FadJ) and two beta chains (FadI).
Subcellular location	Cytoplasm.
Similarity	Belongs to the thiolase-like superfamily. Thiolase family.

Cytoplasm
Acyltransferase
Fatty acid metabolism
Lipid degradation
Lipid metabolism
Transferase

GO:0003988; Molecular function: acetyl-CoA C-acyltransferase activity.
GO:0006631; Biological process: fatty acid metabolic process.
GO:0016042; Biological process: lipid catabolic process.
GO:0005737; Cellular component: cytoplasm.

PROSITE	PS00098; THIOLASE_1; 1;
	PS00737; THIOLASE_2; 1;
	PS00099; THIOLASE_3; 1;
Pfam	PF02803; Thiolase_C; 1;
	PF00108; Thiolase_N; 1;
TIGRFAMs	TIGR01930; AcCoA-C-Actrans; 1;
	TIGR02446; FadI; 1;

From: FADI_ECOLI (P76503)

Key

From

To

Description

Tag

Condition

FTGroup

ACT_SITE

99

99

Acyl-thioester intermediate

C

ACT_SITE

392

392

Proton acceptor

H

ACT_SITE

422

422

Proton acceptor

C

Size range	435-442 amino acids
Related rules	None
Fusion	None

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