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HAMAP rule MF_01620
General rule information
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| Accession | MF_01620 |
| Dates | 18-NOV-2005 (Created)
7-MAY-2024 (Last updated, Version 24) |
| Name | FadA |
| Scope(s) |
Bacteria Gammaproteobacteria |
| Template(s) | P21151 (FADA_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01620 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | FADA |
| Protein name | RecName: Full=3-ketoacyl-CoA thiolase; EC=2.3.1.16; AltName: Full=Acetyl-CoA acyltransferase; AltName: Full=Beta-ketothiolase; AltName: Full=Fatty acid oxidation complex subunit beta; |
| Gene name | Name=fadA; |
Comments
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| FUNCTION | Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. |
| CATALYTIC ACTIVITY | Reaction=acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA; Xref=Rhea:RHEA:21564, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58342, ChEBI:CHEBI:90726; EC=2.3.1.16; |
| PATHWAY | Lipid metabolism; fatty acid beta-oxidation. |
| SUBUNIT | Heterotetramer of two alpha chains (FadB) and two beta chains (FadA). |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the thiolase-like superfamily. Thiolase family. |
Keywords
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Gene Ontology
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| GO:0003988; Molecular function:acetyl-CoA C-acyltransferase activity |
| GO:0006635; Biological process:fatty acid beta-oxidation |
| GO:0016042; Biological process:lipid catabolic process |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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| PROSITE | PS00098; THIOLASE_1; 1; |
| PROSITE | PS00737; THIOLASE_2; 1; |
| PROSITE | PS00099; THIOLASE_3; 1; |
| Pfam | PF02803; Thiolase_C; 1; |
| Pfam | PF00108; Thiolase_N; 1; |
| NCBIfam | TIGR01930; AcCoA-C-Actrans; 1; |
| NCBIfam | TIGR02445; FadA; 1; |
Features
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| From: FADA_ECOLI (P21151) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 91 | 91 | /note="Acyl-thioester intermediate" | C | ||||||||
| ACT_SITE | 343 | 343 | /note="Proton acceptor" | H | ||||||||
| ACT_SITE | 373 | 373 | /note="Proton acceptor" | C | ||||||||
Additional information
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| Size range | 386-392 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |