Home  |  Contact
Annotation rule MF_01620
Send feedback

General rule information [?]

Accession MF_01620
Dates 18-NOV-2005 (Created)
19-NOV-2019 (Last updated, Version 22)
Name FadA
Scope
Bacteria; Gammaproteobacteria
Template P21151 (FADA_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
FADA
Protein name
RecName: Full=3-ketoacyl-CoA thiolase;
EC 2.3.1.16;
AltName: Full=Acetyl-CoA acyltransferase;
AltName: Full=Beta-ketothiolase;
AltName: Full=Fatty acid oxidation complex subunit beta;
Gene name
fadA

Comments [?]

Function Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed.
Catalytic activity RHEA:21564: acetyl-CoA + an acyl-CoA = a 3-oxoacyl-CoA + CoA
EC 2.3.1.16
Pathway Lipid metabolism; fatty acid beta-oxidation.
Subunit Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).
Subcellular location Cytoplasm.
Similarity Belongs to the thiolase-like superfamily. Thiolase family.

Keywords [?]


Gene Ontology [?]

GO:0003988; Molecular function: acetyl-CoA C-acyltransferase activity.
GO:0006631; Biological process: fatty acid metabolic process.
GO:0016042; Biological process: lipid catabolic process.
GO:0005737; Cellular component: cytoplasm.

Cross-references [?]

PROSITE PS00098; THIOLASE_1; 1;
PS00737; THIOLASE_2; 1;
PS00099; THIOLASE_3; 1;
Pfam PF02803; Thiolase_C; 1;
PF00108; Thiolase_N; 1;
TIGRFAMs TIGR01930; AcCoA-C-Actrans; 1;
TIGR02445; FadA; 1;

Features [?]

From: FADA_ECOLI (P21151)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     91     91       Acyl-thioester intermediate     C  
ACT_SITE     343     343       Proton acceptor     H  
ACT_SITE     373     373       Proton acceptor     C  

Additional information [?]

Size range 386-392 amino acids
Related rules None
Fusion None