HAMAP rule MF_01624
General rule information
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| Accession | MF_01624 |
| Dates | 7-DEC-2005 (Created)
1-JUN-2023 (Last updated, Version 20) |
| Name | Arsenate_reduct |
| Scope(s) |
Bacteria Bacillota |
| Template(s) | P0A006 (ARSC_STAAU); P45947 (ARSC_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01624 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ARSC |
| Protein name | RecName: Full=Arsenate reductase; EC=1.20.4.4; |
| Gene name | Name=arsC; |
Comments
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| FUNCTION | Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]. |
| CATALYTIC ACTIVITY | Reaction=[thioredoxin]-dithiol + arsenate + H(+) = [thioredoxin]- disulfide + arsenite + H2O; Xref=Rhea:RHEA:43848, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:29950, ChEBI:CHEBI:48597, ChEBI:CHEBI:50058; EC=1.20.4.4; |
| SUBCELLULAR LOCATION | Cytoplasm. |
| SIMILARITY | Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily. |
Keywords
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| Arsenical resistance | |
| Cytoplasm | |
| case <FT:4> or <FT:5> | |
| Disulfide bond | |
| end case | |
| Oxidoreductase | |
| Redox-active center | |
Gene Ontology
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| GO:0030612; Molecular function:arsenate reductase (thioredoxin) activity |
| GO:0005737; Cellular component:cytoplasm |
Cross-references
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Features
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| From: ARSC_STAAU (P0A006) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 10 | 10 | /note="Nucleophile" | C | ||||||||
| ACT_SITE | 82 | 82 | /note="Nucleophile" | C | ||||||||
| ACT_SITE | 89 | 89 | /note="Nucleophile" | C | ||||||||
| DISULFID | 10 | 82 | /note="Redox-active; alternate" | C-x*-C | ||||||||
| DISULFID | 82 | 89 | /note="Redox-active; alternate" | C-x*-C | ||||||||
Additional information
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| Size range | 130-160 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |