HAMAP rule MF_01633
General rule information
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| Accession | MF_01633 |
| Dates | 3-JUL-2006 (Created)
1-JUN-2023 (Last updated, Version 23) |
| Name | QueC |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P77756 (QUEC_ECOLI); O31675 (QUEC_BACSU); Q6D820 (QUEC_PECAS); [ Recover all ] |
| Triggered by |
HAMAP; MF_01633 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | QUEC |
| case <OC:Bacteria> | |
| Protein name | RecName: Full=7-cyano-7-deazaguanine synthase; EC=6.3.4.20; AltName: Full=7-cyano-7-carbaguanine synthase; AltName: Full=PreQ(0) synthase; AltName: Full=Queuosine biosynthesis protein QueC; |
| else case <OC:Archaea> | |
| Protein name | RecName: Full=7-cyano-7-deazaguanine synthase; EC=6.3.4.20; AltName: Full=7-cyano-7-carbaguanine synthase; AltName: Full=Archaeosine biosynthesis protein QueC; AltName: Full=PreQ(0) synthase; |
| end case | |
| Gene name | Name=queC; |
Comments
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| FUNCTION | Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). |
| CATALYTIC ACTIVITY | Reaction=7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7- deazaguanine + ADP + H(+) + H2O + phosphate; Xref=Rhea:RHEA:27982, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45075, ChEBI:CHEBI:61036, ChEBI:CHEBI:456216; EC=6.3.4.20; |
| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| end case | |
| PATHWAY | Purine metabolism; 7-cyano-7-deazaguanine biosynthesis. |
| case <OC:Bacillota> | |
| SUBUNIT | Homodimer. |
| end case | |
| SIMILARITY | Belongs to the QueC family. |
Keywords
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| ATP-binding | |
| Ligase | |
| Nucleotide-binding | |
| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
| case <OC:Bacteria> | |
| Queuosine biosynthesis | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds | |
| case <FTGroup:1> | |
| GO:0008270; Molecular function:zinc ion binding | |
| end case | |
| case <OCellular component:Bacteria> | |
| GO:0008616; Biological process:queuosine biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF06508; ExsB; 1; |
| NCBIfam | TIGR00364; TIGR00364; 1; |
| PIRSF | PIRSF006293; ExsB; 1; |
Features
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| From: QUEC_BACSU (O31675) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 10 | 20 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 195 | 195 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 198 | 198 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 201 | 201 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 196-269 amino acids |
| Related rules |
None |
| Fusion | Nter: <type-2 glutamine amidotransferase domain> Cter: None |