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HAMAP rule MF_01633

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General rule information [?]

Accession MF_01633
Dates 3-JUL-2006 (Created)
1-JUN-2023 (Last updated, Version 23)
Name QueC
Scope(s) Bacteria
Archaea
Template(s) P77756 (QUEC_ECOLI); O31675 (QUEC_BACSU); Q6D820 (QUEC_PECAS); [ Recover all ]
Triggered by HAMAP; MF_01633 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier QUEC
case <OC:Bacteria>
Protein name RecName: Full=7-cyano-7-deazaguanine synthase;
                 EC=6.3.4.20;
AltName: Full=7-cyano-7-carbaguanine synthase;
AltName: Full=PreQ(0) synthase;
AltName: Full=Queuosine biosynthesis protein QueC;
else case <OC:Archaea>
Protein name RecName: Full=7-cyano-7-deazaguanine synthase;
                 EC=6.3.4.20;
AltName: Full=7-cyano-7-carbaguanine synthase;
AltName: Full=Archaeosine biosynthesis protein QueC;
AltName: Full=PreQ(0) synthase;
end case
Gene name Name=queC;

Comments [?]

FUNCTIONCatalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).
CATALYTIC ACTIVITY Reaction=7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7- deazaguanine + ADP + H(+) + H2O + phosphate; Xref=Rhea:RHEA:27982, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:45075, ChEBI:CHEBI:61036, ChEBI:CHEBI:456216; EC=6.3.4.20;
case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case
PATHWAYPurine metabolism; 7-cyano-7-deazaguanine biosynthesis.
case <OC:Bacillota>
SUBUNITHomodimer.
end case
SIMILARITYBelongs to the QueC family.

Keywords [?]

ATP-binding
Ligase
Nucleotide-binding
case <FTGroup:1>
Metal-binding
Zinc
end case
case <OC:Bacteria>
Queuosine biosynthesis
end case

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016879; Molecular function:ligase activity, forming carbon-nitrogen bonds
case <FTGroup:1>
GO:0008270; Molecular function:zinc ion binding
end case
case <OCellular component:Bacteria>
GO:0008616; Biological process:queuosine biosynthetic process
end case

Cross-references [?]

Pfam PF06508; ExsB; 1;
NCBIfam TIGR00364; TIGR00364; 1;
PIRSF PIRSF006293; ExsB; 1;

Features [?]

From: QUEC_BACSU (O31675)
Key From To Description Tag Condition FTGroup
BINDING 10 20 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
BINDING 186 186 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 195 195 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 198 198 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1
BINDING 201 201 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
C 1

Additional information [?]

Size range 196-269 amino acids
Related rules None
Fusion Nter: <type-2 glutamine amidotransferase domain> Cter: None



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