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Annotation rule MF_01634
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General rule information [?]

Accession MF_01634
Dates 11-JUL-2006 (Created)
14-MAY-2022 (Last updated, Version 14)
Name TgtA_arch
Scope
Archaea
Templates O58843 (ATGT_PYRHO); Q57878 (ATGT_METJA): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ATGT
Protein name
RecName: Full=tRNA-guanine(15) transglycosylase;
EC 2.4.2.48;
AltName: Full=7-cyano-7-deazaguanine tRNA-ribosyltransferase;
AltName: Full=Archaeal tRNA-guanine transglycosylase;
Gene name
tgtA

Comments [?]

Function Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
Catalytic activity RHEA:43164: 7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine
EC 2.4.2.48
Cofactor Zn(2+)
Note: Binds 1 zinc ion per subunit.
Pathway tRNA modification; archaeosine-tRNA biosynthesis.
Similarity Belongs to the archaeosine tRNA-ribosyltransferase family.

Keywords [?]

Glycosyltransferase
Metal-binding
Transferase
tRNA processing
Zinc

Gene Ontology [?]

GO:0008033; Biological process: tRNA processing.

Cross-references [?]

PROSITE PS50890; PUA; 1; trigger=PRU00161;
Pfam PF01472; PUA; 1;
PF01702; TGT; 1;
TIGRFAMs TIGR00432; Arcsn_tRNA_tgt; 1;
TIGR00449; Tgt_general; 1;
TIGR00451; Unchar_dom_2; 1;

Features [?]

From: ATGT_PYRHO (O58843)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     95     95       Nucleophile     D  
BINDING     279     279       /ligand="Zn(2+)" /ligand_id="29105     C  
BINDING     281     281       /ligand="Zn(2+)" /ligand_id="29105     C  
BINDING     284     284       /ligand="Zn(2+)" /ligand_id="29105     C  
BINDING     130     130       /ligand="substrate     D  
BINDING     196     196       /ligand="substrate     [GA]  

Additional information [?]

Size range 410-674 amino acids
Related rules None
Fusion None


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