HAMAP rule MF_01634
General rule information
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| Accession |
MF_01634 |
| Dates |
11-JUL-2006 (Created)
19-NOV-2022 (Last updated, Version 15) |
Propagated annotation
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Identifier, protein and gene names
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| Protein name |
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RecName:
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Full=tRNA-guanine(15) transglycosylase;
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EC 2.4.2.48;
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AltName:
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Full=7-cyano-7-deazaguanine tRNA-ribosyltransferase;
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AltName:
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Full=Archaeal tRNA-guanine transglycosylase;
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| Function |
Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. |
| Catalytic activity |
RHEA:43164: 7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine
EC 2.4.2.48
|
| Cofactor |
Zn(2+)
Note: Binds 1 zinc ion per subunit. |
| Pathway |
tRNA modification; archaeosine-tRNA biosynthesis. |
| Similarity |
Belongs to the archaeosine tRNA-ribosyltransferase family. |
| From: ATGT_PYRHO (O58843) |
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Key
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From
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To
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Description
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Tag
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Condition
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FTGroup
|
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ACT_SITE
|
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95
|
|
95
|
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Nucleophile
|
|
|
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D
|
|
|
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BINDING
|
|
279
|
|
279
|
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/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105
|
|
|
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C
|
|
|
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BINDING
|
|
281
|
|
281
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105
|
|
|
|
C
|
|
|
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BINDING
|
|
284
|
|
284
|
|
/ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105
|
|
|
|
C
|
|
|
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BINDING
|
|
130
|
|
130
|
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/ligand="substrate
|
|
|
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D
|
|
|
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BINDING
|
|
196
|
|
196
|
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/ligand="substrate
|
|
|
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[GA]
|
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Additional information
[?]
| Size range |
410-674 amino acids |
| Related rules |
None |
| Fusion |
None |
