![]() |
|
Annotation rule MF_01634 |
Accession | MF_01634 |
Dates | 11-JUL-2006 (Created) 14-MAY-2022 (Last updated, Version 14) |
Name | TgtA_arch |
Scope | Archaea |
Templates | O58843 (ATGT_PYRHO); Q57878 (ATGT_METJA): [Recover all] |
Triggered by |
Identifier |
|
Protein name |
|
Gene name |
|
Function | Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. |
Catalytic activity | RHEA:43164: 7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7-carbaguanosine(15) in tRNA + guanine
EC 2.4.2.48 |
Cofactor | Zn(2+) Note: Binds 1 zinc ion per subunit. |
Pathway | tRNA modification; archaeosine-tRNA biosynthesis. |
Similarity | Belongs to the archaeosine tRNA-ribosyltransferase family. |
PROSITE | PS50890; PUA; 1; trigger=PRU00161; |
Pfam | PF01472; PUA; 1; |
PF01702; TGT; 1; | |
TIGRFAMs | TIGR00432; Arcsn_tRNA_tgt; 1; |
TIGR00449; Tgt_general; 1; | |
TIGR00451; Unchar_dom_2; 1; |
From: ATGT_PYRHO (O58843) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 95 | 95 | Nucleophile | D | ||||||||
BINDING | 279 | 279 | /ligand="Zn(2+)" /ligand_id="29105 | C | ||||||||
BINDING | 281 | 281 | /ligand="Zn(2+)" /ligand_id="29105 | C | ||||||||
BINDING | 284 | 284 | /ligand="Zn(2+)" /ligand_id="29105 | C | ||||||||
BINDING | 130 | 130 | /ligand="substrate | D | ||||||||
BINDING | 196 | 196 | /ligand="substrate | [GA] |
Size range | 410-674 amino acids |
Related rules | None |
Fusion | None |