HAMAP rule MF_01634
General rule information
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| Accession | MF_01634 |
| Dates | 11-JUL-2006 (Created)
3-SEP-2024 (Last updated, Version 18) |
| Name | TgtA_arch |
| Scope(s) |
Archaea |
| Template(s) | O58843 (ATGT_PYRHO); Q57878 (ATGT_METJA); [ Recover all ] |
| Triggered by |
HAMAP; MF_01634 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ATGT |
| Protein name | RecName: Full=tRNA-guanine(15) transglycosylase; EC=2.4.2.48; AltName: Full=7-cyano-7-deazaguanine tRNA-ribosyltransferase; AltName: Full=Archaeal tRNA-guanine transglycosylase; |
| Gene name | Name=tgtA; |
Comments
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| FUNCTION | Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs. |
| CATALYTIC ACTIVITY | Reaction=guanosine(15) in tRNA + 7-cyano-7-deazaguanine = 7-cyano-7- carbaguanosine(15) in tRNA + guanine; Xref=Rhea:RHEA:43164, Rhea:RHEA-COMP:10371, Rhea:RHEA-COMP:10372, ChEBI:CHEBI:16235, ChEBI:CHEBI:45075, ChEBI:CHEBI:74269, ChEBI:CHEBI:82850; EC=2.4.2.48; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| PATHWAY | tRNA modification; archaeosine-tRNA biosynthesis. |
| SIMILARITY | Belongs to the archaeosine tRNA-ribosyltransferase family. |
Keywords
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Gene Ontology
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| GO:0016763; Molecular function:pentosyltransferase activity |
| GO:0008270; Molecular function:zinc ion binding |
| GO:0006400; Biological process:tRNA modification |
Cross-references
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| PROSITE | PS50890; PUA; 1; |
| Pfam | PF01472; PUA; 1; |
| Pfam | PF01702; TGT; 1; |
| NCBIfam | TIGR00432; Arcsn_tRNA_tgt; 1; |
| NCBIfam | TIGR00449; Tgt_general; 1; |
| NCBIfam | TIGR00451; Unchar_dom_2; 1; |
Features
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| From: ATGT_PYRHO (O58843) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 95 | 95 | /note="Nucleophile" | D | ||||||||
| BINDING | 279 | 279 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | ||||||||
| BINDING | 281 | 281 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | ||||||||
| BINDING | 284 | 284 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | ||||||||
| BINDING | 130 | 130 | /ligand="substrate" | D | ||||||||
| BINDING | 196 | 196 | /ligand="substrate" | [GA] | ||||||||
Additional information
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| Size range | 410-674 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |