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HAMAP rule MF_01634

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General rule information [?]

Accession MF_01634
Dates 11-JUL-2006 (Created)
31-JAN-2024 (Last updated, Version 17)
Name TgtA_arch
Scope(s) Archaea
Template(s) O58843 (ATGT_PYRHO); Q57878 (ATGT_METJA); [ Recover all ]
Triggered by HAMAP; MF_01634 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ATGT
Protein name RecName: Full=tRNA-guanine(15) transglycosylase;
AltName: Full=7-cyano-7-deazaguanine tRNA-ribosyltransferase;
AltName: Full=Archaeal tRNA-guanine transglycosylase;
Gene name Name=tgtA;

Comments [?]

FUNCTIONExchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.
CATALYTIC ACTIVITY Reaction=7-cyano-7-deazaguanine + guanosine(15) in tRNA = 7-cyano-7- carbaguanosine(15) in tRNA + guanine; Xref=Rhea:RHEA:43164, Rhea:RHEA-COMP:10371, Rhea:RHEA-COMP:10372, ChEBI:CHEBI:16235, ChEBI:CHEBI:45075, ChEBI:CHEBI:74269, ChEBI:CHEBI:82850; EC=;
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
PATHWAYtRNA modification; archaeosine-tRNA biosynthesis.
SIMILARITYBelongs to the archaeosine tRNA-ribosyltransferase family.

Keywords [?]

Gene Ontology [?]

GO:0016763; Molecular function:pentosyltransferase activity
GO:0008270; Molecular function:zinc ion binding
GO:0006400; Biological process:tRNA modification

Cross-references [?]

PROSITE PS50890; PUA; 1;
Pfam PF01472; PUA; 1;
Pfam PF01702; TGT; 1;
NCBIfam TIGR00432; Arcsn_tRNA_tgt; 1;
NCBIfam TIGR00449; Tgt_general; 1;
NCBIfam TIGR00451; Unchar_dom_2; 1;

Features [?]

From: ATGT_PYRHO (O58843)
Key From To Description Tag Condition FTGroup
ACT_SITE 95 95 /note="Nucleophile" D
BINDING 279 279 /ligand="Zn(2+)"
BINDING 281 281 /ligand="Zn(2+)"
BINDING 284 284 /ligand="Zn(2+)"
BINDING 130 130 /ligand="substrate" D
BINDING 196 196 /ligand="substrate" [GA]

Additional information [?]

Size range 410-674 amino acids
Related rules None
Fusion Nter: None Cter: None

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