HAMAP rule MF_01642

General rule information [?]

Accession	MF_01642
Dates	7-NOV-2007 (Created) 17-FEB-2023 (Last updated, Version 27)

Name	DapL_aminotrans_1

Scope

Bacteria; Aquificae

Bacteria; Bacteroidota

Bacteria; Chlamydiota

Bacteria; Chloroflexota

Bacteria; Cyanobacteriota

Bacteria; Clostridia

Bacteria; Deltaproteobacteria

Bacteria; Spirochaetota

Archaea; Methanobacteriales

Templates

O84395 (DAPAT_CHLTR); Q6MDE0 (DAPAT_PARUW); Q55828 (DAPAT_SYNY3); O26158 (DAPAT_METTH); Q18T09 (DAPAT_DESHD); Q72NJ3 (DAPAT_LEPIC); Q2RK33 (DAPAT_MOOTA); Q5LC03 (DAPAT_BACFN); A3DK17 (DAPAT_ACET2); Q7NDX4 (DAPAT_GLOVI); A0LEA5 (DAPAT_SYNFM): [Recover all]

Triggered by

HAMAP; MF_01642 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

DAPAT

Protein name

RecName:		Full=LL-diaminopimelate aminotransferase;
		Short=DAP-AT;
		Short=DAP-aminotransferase;
		Short=LL-DAP-aminotransferase;
		EC 2.6.1.83;

Gene name

dapL

Comments [?]

Function	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
Catalytic activity	RHEA:23988: (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate EC 2.6.1.83
Cofactor	pyridoxal 5'-phosphate
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.
Subunit	Homodimer.
Similarity	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.

Keywords [?]

Aminotransferase
Pyridoxal phosphate
Transferase

Gene Ontology [?]

GO:0010285; Molecular function: L,L-diaminopimelate aminotransferase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0033362; Biological process: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway.

Cross-references [?]

PROSITE	PS00105; AA_TRANSFER_CLASS_1; 1;
Pfam	PF00155; Aminotran_1_2; 1;

Features [?]

From: DAPAT_CHLTR (O84395)

Key From To Description Tag Condition FTGroup

BINDING 104 105 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 [AST]-K

BINDING 233 235 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 S-x-S

BINDING 14 14 /ligand="substrate Y

BINDING 41 41 /ligand="substrate G

BINDING 71 71 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 Y

BINDING 105 105 /ligand="substrate K

BINDING 128 128 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 [YF]

BINDING 128 128 /ligand="substrate [YF]

BINDING 174 174 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 N

BINDING 174 174 /ligand="substrate N

BINDING 205 205 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 Y

BINDING 244 244 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 R

BINDING 275 275 /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326 N

BINDING 275 275 /ligand="substrate N

BINDING 369 369 /ligand="substrate R

MOD_RES 236 236 N6-(pyridoxal phosphate)lysine K

Additional information [?]

Size range	386-416 amino acids
Related rules	None
Fusion	None

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