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HAMAP rule MF_01642

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General rule information [?]

Accession MF_01642
Dates 7-NOV-2007 (Created)
14-MAY-2024 (Last updated, Version 28)
Name DapL_aminotrans_1
Scope(s) Bacteria
Aquificia
Bacteroidota
Chlamydiota
Chloroflexota
Cyanobacteriota
Clostridia
Deltaproteobacteria
Spirochaetota
Archaea
Methanobacteriales
Template(s) O84395 (DAPAT_CHLTR); Q6MDE0 (DAPAT_PARUW); Q55828 (DAPAT_SYNY3); O26158 (DAPAT_METTH); Q18T09 (DAPAT_DESHD); Q72NJ3 (DAPAT_LEPIC); Q2RK33 (DAPAT_MOOTA); Q5LC03 (DAPAT_BACFN); A3DK17 (DAPAT_ACET2); Q7NDX4 (DAPAT_GLOVI); A0LEA5 (DAPAT_SYNFM); [ Recover all ]
Triggered by HAMAP; MF_01642 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier DAPAT
Protein name RecName: Full=LL-diaminopimelate aminotransferase;
                 Short=DAP-AT;
                 Short=DAP-aminotransferase;
                 Short=LL-DAP-aminotransferase;
                 EC=2.6.1.83;
Gene name Name=dapL;

Comments [?]

FUNCTIONInvolved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate.
CATALYTIC ACTIVITY Reaction=(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)- 2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate; Xref=Rhea:RHEA:23988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:16845, ChEBI:CHEBI:29985, ChEBI:CHEBI:57609; EC=2.6.1.83;
COFACTOR Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
PATHWAYAmino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.
SUBUNITHomodimer.
SIMILARITYBelongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0010285; Molecular function:L,L-diaminopimelate aminotransferase activity
GO:0030170; Molecular function:pyridoxal phosphate binding
GO:0033362; Biological process:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway

Cross-references [?]

PROSITE PS00105; AA_TRANSFER_CLASS_1; 1;
Pfam PF00155; Aminotran_1_2; 1;

Features [?]

From: DAPAT_CHLTR (O84395)
Key From To Description Tag Condition FTGroup
BINDING 104 105 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
[AST]-K
BINDING 233 235 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
S-x-S
BINDING 14 14 /ligand="substrate" Y
BINDING 41 41 /ligand="substrate" G
BINDING 71 71 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
Y
BINDING 105 105 /ligand="substrate" K
BINDING 128 128 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
[YF]
BINDING 128 128 /ligand="substrate" [YF]
BINDING 174 174 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
N
BINDING 174 174 /ligand="substrate" N
BINDING 205 205 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
Y
BINDING 244 244 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
R
BINDING 275 275 /ligand="pyridoxal 5'-phosphate"
/ligand_id="ChEBI:CHEBI:597326"
N
BINDING 275 275 /ligand="substrate" N
BINDING 369 369 /ligand="substrate" R
MOD_RES 236 236 /note="N6-(pyridoxal phosphate)lysine" K

Additional information [?]

Size range 386-416 amino acids
Related rules None
Fusion Nter: None Cter: None



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