HAMAP rule MF_01642
General rule information
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| PURL | https://purl.expasy.org/hamap/rule/MF_01642 |
| Accession | MF_01642 |
| Dates | 07-NOV-2007 (Created)
09-JAN-2025 (Last updated, Version 31) |
| Name | DapL_aminotrans_1 |
| Scope(s) |
Bacteria Aquificia Bacteroidota Chlamydiota Chloroflexota Cyanobacteriota Clostridia Deltaproteobacteria Spirochaetota Archaea Methanobacteriales |
| Template(s) | O84395; Q6MDE0; Q55828; O26158; Q18T09; Q72NJ3; Q2RK33; Q5LC03; A3DK17; Q7NDX4; A0LEA5; [ Recover all ] |
| Triggered by |
HAMAP; MF_01642 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | DAPAT |
| Protein name | RecName: Full=LL-diaminopimelate aminotransferase; Short=DAP-AT; Short=DAP-aminotransferase; Short=LL-DAP-aminotransferase; EC=2.6.1.83; |
| Gene name | Name=dapL; |
Comments
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| FUNCTION | Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL- diaminopimelate. |
| CATALYTIC ACTIVITY | Reaction=(2S,6S)-2,6-diaminopimelate + 2-oxoglutarate = (S)-2,3,4,5- tetrahydrodipicolinate + L-glutamate + H2O + H(+); Xref=Rhea:RHEA:23988, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16810, ChEBI:CHEBI:16845, ChEBI:CHEBI:29985, ChEBI:CHEBI:57609; EC=2.6.1.83; |
| COFACTOR | Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; |
| PATHWAY | Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1. |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily. |
Keywords
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Gene Ontology
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| GO:0010285; Molecular function:L,L-diaminopimelate aminotransferase activity |
| GO:0030170; Molecular function:pyridoxal phosphate binding |
| GO:0033362; Biological process:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway |
Cross-references
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Features
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| From: DAPAT_CHLTR (O84395) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 104 | 105 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
[AST]-K | ||||||||
| BINDING | 233 | 235 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
S-x-S | ||||||||
| BINDING | 14 | 14 | /ligand="substrate" | Y | ||||||||
| BINDING | 41 | 41 | /ligand="substrate" | G | ||||||||
| BINDING | 71 | 71 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
Y | ||||||||
| BINDING | 105 | 105 | /ligand="substrate" | K | ||||||||
| BINDING | 128 | 128 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
[YF] | ||||||||
| BINDING | 128 | 128 | /ligand="substrate" | [YF] | ||||||||
| BINDING | 174 | 174 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
N | ||||||||
| BINDING | 174 | 174 | /ligand="substrate" | N | ||||||||
| BINDING | 205 | 205 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
Y | ||||||||
| BINDING | 244 | 244 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
R | ||||||||
| BINDING | 275 | 275 | /ligand="pyridoxal 5'-phosphate" /ligand_id="ChEBI:CHEBI:597326" |
N | ||||||||
| BINDING | 275 | 275 | /ligand="substrate" | N | ||||||||
| BINDING | 369 | 369 | /ligand="substrate" | R | ||||||||
| MOD_RES | 236 | 236 | /note="N6-(pyridoxal phosphate)lysine" | K | ||||||||
Additional information
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| Size range | 386-416 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |