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Annotation rule MF_01642
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General rule information [?]

Accession MF_01642
Dates 7-NOV-2007 (Created)
21-JAN-2020 (Last updated, Version 22)
Name DapL_aminotrans_1
Scope
Bacteria; Aquificae
Bacteria; Bacteroidetes
Bacteria; Chlamydiae
Bacteria; Chloroflexi
Bacteria; Cyanobacteria
Bacteria; Clostridia
Bacteria; Deltaproteobacteria
Bacteria; Spirochaetes
Archaea; Methanobacteriales
Templates O84395 (DAPAT_CHLTR); Q6MDE0 (DAPAT_PARUW); Q55828 (DAPAT_SYNY3); O26158 (DAPAT_METTH); Q18T09 (DAPAT_DESHD); Q72NJ3 (DAPAT_LEPIC); Q2RK33 (DAPAT_MOOTA); Q5LC03 (DAPAT_BACFN); A3DK17 (DAPAT_HUNT2); Q7NDX4 (DAPAT_GLOVI); A0LEA5 (DAPAT_SYNFM): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
DAPAT
Protein name
RecName: Full=LL-diaminopimelate aminotransferase;
Short=DAP-AT;
Short=DAP-aminotransferase;
Short=LL-DAP-aminotransferase;
EC 2.6.1.83;
Gene name
dapL

Comments [?]

Function Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.
Catalytic activity RHEA:23988: (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate
EC 2.6.1.83
Cofactor pyridoxal 5'-phosphate
Pathway Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.
Subunit Homodimer.
Similarity Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.

Keywords [?]


Gene Ontology [?]

GO:0010285; Molecular function: L,L-diaminopimelate aminotransferase activity.
GO:0030170; Molecular function: pyridoxal phosphate binding.
GO:0033362; Biological process: lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway.

Cross-references [?]

PROSITE PS00105; AA_TRANSFER_CLASS_1; 1;
Pfam PF00155; Aminotran_1_2; 1;

Features [?]

From: DAPAT_CHLTR (O84395)
Key     From     To       Description   Tag   Condition   FTGroup
REGION     104     105       Pyridoxal phosphate binding     [AST]-K  
REGION     233     235       Pyridoxal phosphate binding     S-x-S  
BINDING     14     14       Substrate     Y  
BINDING     41     41       Substrate; via amide nitrogen     G  
BINDING     71     71       Pyridoxal phosphate     Y  
BINDING     105     105       Substrate     K  
BINDING     128     128       Pyridoxal phosphate     [YF]  
BINDING     128     128       Substrate     [YF]  
BINDING     174     174       Pyridoxal phosphate     N  
BINDING     174     174       Substrate     N  
BINDING     205     205       Pyridoxal phosphate     Y  
BINDING     244     244       Pyridoxal phosphate     R  
BINDING     275     275       Pyridoxal phosphate     N  
BINDING     275     275       Substrate     N  
BINDING     369     369       Substrate     R  
MOD_RES     236     236       N6-(pyridoxal phosphate)lysine     K  

Additional information [?]

Size range 386-416 amino acids
Related rules None
Fusion None