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Annotation rule MF_01645 |
Accession | MF_01645 |
Dates | 14-JAN-2008 (Created) 19-NOV-2019 (Last updated, Version 25) |
Name | Hydantoinase |
Scope | Bacteria |
Templates | P77671 (ALLB_ECOLI); O32137 (ALLB_BACSU): [Recover all] |
Triggered by |
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Function | Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. |
Catalytic activity | RHEA:17029: (S)-allantoin + H2O = allantoate + H(+)
EC 3.5.2.5 |
Cofactor | Zn(2+) Note: Binds 2 Zn(2+) ions per subunit. |
Pathway | Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. |
Subunit | Homotetramer. |
Ptm | Carboxylation allows a single lysine to coordinate two zinc ions. |
Similarity | Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. |
From: ALLB_ECOLI (P77671) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
METAL | 59 | 59 | Zinc 1 | H | ||||||||
METAL | 61 | 61 | Zinc 1 | H | ||||||||
METAL | 146 | 146 | Zinc 1; via carbamate group | K | ||||||||
METAL | 146 | 146 | Zinc 2; via carbamate group | K | ||||||||
METAL | 186 | 186 | Zinc 2 | H | ||||||||
METAL | 242 | 242 | Zinc 2 | H | ||||||||
METAL | 315 | 315 | Zinc 1 | D | ||||||||
MOD_RES | 146 | 146 | N6-carboxylysine | K |
Size range | 438-457 amino acids |
Related rules | None |
Fusion | None |