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Annotation rule MF_01645
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General rule information [?]

Accession MF_01645
Dates 14-JAN-2008 (Created)
19-NOV-2019 (Last updated, Version 25)
Name Hydantoinase
Scope
Bacteria
Templates P77671 (ALLB_ECOLI); O32137 (ALLB_BACSU): [Recover all]
Triggered by

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ALLB
Protein name
RecName: Full=Allantoinase;
EC 3.5.2.5;
AltName: Full=Allantoin-utilizing enzyme;
case <OC:Bacillus>
Gene name
allB, pucH
else
Gene name
allB
end case

Comments [?]

Function Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.
Catalytic activity RHEA:17029: (S)-allantoin + H2O = allantoate + H(+)
EC 3.5.2.5
Cofactor Zn(2+)
Note: Binds 2 Zn(2+) ions per subunit.
Pathway Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.
Subunit Homotetramer.
Ptm Carboxylation allows a single lysine to coordinate two zinc ions.
Similarity Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.

Keywords [?]

Hydrolase
Metal-binding
Purine metabolism
Zinc

Gene Ontology [?]

GO:0004038; Molecular function: allantoinase activity.
GO:0000256; Biological process: allantoin catabolic process.

Cross-references [?]

Pfam PF01979; Amidohydro_1; 1;
TIGRFAMs TIGR00857; PyrC_multi; 1;

Features [?]

From: ALLB_ECOLI (P77671)
Key     From     To       Description   Tag   Condition   FTGroup
METAL     59     59       Zinc 1     H  
METAL     61     61       Zinc 1     H  
METAL     146     146       Zinc 1; via carbamate group     K  
METAL     146     146       Zinc 2; via carbamate group     K  
METAL     186     186       Zinc 2     H  
METAL     242     242       Zinc 2     H  
METAL     315     315       Zinc 1     D  
MOD_RES     146     146       N6-carboxylysine     K  

Additional information [?]

Size range 438-457 amino acids
Related rules None
Fusion None


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