HAMAP rule MF_01645
General rule information
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| Accession | MF_01645 |
| Dates | 14-JAN-2008 (Created)
1-JUN-2023 (Last updated, Version 28) |
| Name | Hydantoinase |
| Scope(s) |
Bacteria |
| Template(s) | P77671 (ALLB_ECOLI); O32137 (ALLB_BACSU); [ Recover all ] |
| Triggered by |
HAMAP; MF_01645 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | ALLB |
| Protein name | RecName: Full=Allantoinase; EC=3.5.2.5; AltName: Full=Allantoin-utilizing enzyme; |
| case <OC:Bacillus> | |
| Gene name | Name=allB; Synonyms=pucH; |
| else | |
| Gene name | Name=allB; |
| end case | |
Comments
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| FUNCTION | Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring. |
| CATALYTIC ACTIVITY | Reaction=(S)-allantoin + H2O = allantoate + H(+); Xref=Rhea:RHEA:17029, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15678, ChEBI:CHEBI:17536; EC=3.5.2.5; |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 2 Zn(2+) ions per subunit.; |
| PATHWAY | Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1. |
| SUBUNIT | Homotetramer. |
| PTM | Carboxylation allows a single lysine to coordinate two zinc ions. |
| SIMILARITY | Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family. |
Keywords
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Gene Ontology
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| GO:0004038; Molecular function:allantoinase activity |
| GO:0000256; Biological process:allantoin catabolic process |
Cross-references
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Features
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| From: ALLB_ECOLI (P77671) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING | 59 | 59 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 61 | 61 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
H | ||||||||
| BINDING | 146 | 146 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" /note="via carbamate group" |
K | ||||||||
| BINDING | 146 | 146 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" /note="via carbamate group" |
K | ||||||||
| BINDING | 186 | 186 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
| BINDING | 242 | 242 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="2" |
H | ||||||||
| BINDING | 315 | 315 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="1" |
D | ||||||||
| MOD_RES | 146 | 146 | /note="N6-carboxylysine" | K | ||||||||
Additional information
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| Size range | 438-457 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |