HAMAP rule MF_01653
General rule information
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| Accession | MF_01653 |
| Dates | 29-APR-2008 (Created)
26-JAN-2023 (Last updated, Version 19) |
| Name | MhpB |
| Scope(s) |
Bacteria Actinomycetota Pseudomonadota |
| Template(s) | P0ABR9 (MHPB_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01653 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MHPB |
| Protein name | RecName: Full=2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase; EC=1.13.11.16; AltName: Full=3-carboxyethylcatechol 2,3-dioxygenase; |
| Gene name | Name=mhpB; |
Comments
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| FUNCTION | Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively. |
| CATALYTIC ACTIVITY | Reaction=3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6- oxonona-2,4-dienedioate + H(+); Xref=Rhea:RHEA:23840, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:46951, ChEBI:CHEBI:66887; EC=1.13.11.16; |
| CATALYTIC ACTIVITY | Reaction=(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2- hydroxy-6-oxonona-2,4,7-trienedioate + H(+); Xref=Rhea:RHEA:25054, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:58642, ChEBI:CHEBI:66888; EC=1.13.11.16; |
| COFACTOR | Name=Fe(2+); Xref=ChEBI:CHEBI:29033; |
| PATHWAY | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
| SUBUNIT | Homotetramer. |
| SIMILARITY | Belongs to the LigB/MhpB extradiol dioxygenase family. |
Keywords
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Gene Ontology
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| GO:0005506; Molecular function:iron ion binding |
| GO:0047070; Molecular function:3-carboxyethylcatechol 2,3-dioxygenase activity |
| GO:0019439; Biological process:aromatic compound catabolic process |
Cross-references
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| Pfam | PF02900; LigB; 1; |
Features
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| From: MHPB_ECOLI (P0ABR9) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 115 | 115 | /note="Proton donor" | H | ||||||||
| ACT_SITE | 179 | 179 | /note="Proton acceptor" | H | ||||||||
Additional information
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| Size range | 311-331 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |