HAMAP rule MF_01653
General rule information
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Accession | MF_01653 |
Dates | 29-APR-2008 (Created) 26-JAN-2023 (Last updated, Version 19) |
Name | MhpB |
Scope | Bacteria; Actinomycetota
Bacteria; Pseudomonadota |
Template | P0ABR9 (MHPB_ECOLI) |
Triggered by |
Propagated annotation
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Identifier, protein and gene names
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Identifier |
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Protein name |
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Gene name |
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Comments
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Function | Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively. |
Catalytic activity | RHEA:23840: 3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+)
EC 1.13.11.16 |
RHEA:25054: (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+)
EC 1.13.11.16 |
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Cofactor | Fe(2+) |
Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
Subunit | Homotetramer. |
Similarity | Belongs to the LigB/MhpB extradiol dioxygenase family. |
Keywords
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Gene Ontology
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GO:0005506; Molecular function: iron ion binding.
GO:0047070; Molecular function: 3-carboxyethylcatechol 2,3-dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
GO:0047070; Molecular function: 3-carboxyethylcatechol 2,3-dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
Cross-references
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Pfam | PF02900; LigB; 1; |
Features
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From: MHPB_ECOLI (P0ABR9) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 115 | 115 | Proton donor | H | ||||||||
ACT_SITE | 179 | 179 | Proton acceptor | H |
Additional information
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Size range | 311-331 amino acids |
Related rules | None |
Fusion | None |