HAMAP rule MF_01653

General rule information [?]

Accession	MF_01653
Dates	29-APR-2008 (Created) 26-JAN-2023 (Last updated, Version 19)

Name

MhpB

Scope

Bacteria; Actinomycetota

Bacteria; Pseudomonadota

Template

P0ABR9 (MHPB_ECOLI)

Triggered by

HAMAP; MF_01653 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

MHPB

Protein name

RecName:		Full=2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase;
		EC 1.13.11.16;
AltName:		Full=3-carboxyethylcatechol 2,3-dioxygenase;

Gene name

mhpB

Comments [?]

Function	Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6-ketononatrienedioate, respectively.
Catalytic activity	RHEA:23840: 3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H(+) EC 1.13.11.16
	RHEA:25054: (2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H(+) EC 1.13.11.16
Cofactor	Fe(2+)
Pathway	Aromatic compound metabolism; 3-phenylpropanoate degradation.
Subunit	Homotetramer.
Similarity	Belongs to the LigB/MhpB extradiol dioxygenase family.

Keywords [?]

Aromatic hydrocarbons catabolism
Dioxygenase
Iron
Oxidoreductase

Gene Ontology [?]

GO:0005506; Molecular function: iron ion binding.
GO:0047070; Molecular function: 3-carboxyethylcatechol 2,3-dioxygenase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam	PF02900; LigB; 1;

Features [?]

From: MHPB_ECOLI (P0ABR9)

Key From To Description Tag Condition FTGroup

ACT_SITE 115 115 Proton donor H

ACT_SITE 179 179 Proton acceptor H

Additional information [?]

Size range	311-331 amino acids
Related rules	None
Fusion	None

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