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HAMAP rule MF_01653

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General rule information [?]

Accession MF_01653
Dates 29-APR-2008 (Created)
26-JAN-2023 (Last updated, Version 19)
Name MhpB
Scope(s) Bacteria
Template(s) P0ABR9 (MHPB_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01653 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MHPB
Protein name RecName: Full=2,3-dihydroxyphenylpropionate/2,3-dihydroxicinnamic acid 1,2-dioxygenase;
AltName: Full=3-carboxyethylcatechol 2,3-dioxygenase;
Gene name Name=mhpB;

Comments [?]

FUNCTIONCatalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3-dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2-hydroxy-6- ketononatrienedioate, respectively.
CATALYTIC ACTIVITY Reaction=3-(2,3-dihydroxyphenyl)propanoate + O2 = (2Z,4E)-2-hydroxy-6- oxonona-2,4-dienedioate + H(+); Xref=Rhea:RHEA:23840, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:46951, ChEBI:CHEBI:66887; EC=;
CATALYTIC ACTIVITY Reaction=(2E)-3-(2,3-dihydroxyphenyl)prop-2-enoate + O2 = (2Z,4E,7E)-2- hydroxy-6-oxonona-2,4,7-trienedioate + H(+); Xref=Rhea:RHEA:25054, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379, ChEBI:CHEBI:58642, ChEBI:CHEBI:66888; EC=;
COFACTOR Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
PATHWAYAromatic compound metabolism; 3-phenylpropanoate degradation.
SIMILARITYBelongs to the LigB/MhpB extradiol dioxygenase family.

Keywords [?]

Gene Ontology [?]

GO:0005506; Molecular function:iron ion binding
GO:0047070; Molecular function:3-carboxyethylcatechol 2,3-dioxygenase activity
GO:0019439; Biological process:aromatic compound catabolic process

Cross-references [?]

Pfam PF02900; LigB; 1;

Features [?]

Key From To Description Tag Condition FTGroup
ACT_SITE 115 115 /note="Proton donor" H
ACT_SITE 179 179 /note="Proton acceptor" H

Additional information [?]

Size range 311-331 amino acids
Related rules None
Fusion Nter: None Cter: None

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