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Annotation rule MF_01654 |
Accession | MF_01654 |
Dates | 30-APR-2008 (Created) 19-NOV-2019 (Last updated, Version 19) |
Name | MhpC |
Scope | Bacteria; Proteobacteria |
Template | P77044 (MHPC_ECOLI) |
Triggered by |
Identifier |
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Protein name |
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Gene name |
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Function | Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. |
Catalytic activity | RHEA:34187: (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
EC 3.7.1.14 |
RHEA:34191: (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
EC 3.7.1.14 |
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Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
Subunit | Homodimer. |
Similarity | Belongs to the MhpC alpha/beta hydrolase family. |
From: MHPC_ECOLI (P77044) | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
ACT_SITE | 267 | 267 | Proton acceptor | H | ||||||||
SITE | 114 | 114 | Transition state stabilizer | S | ||||||||
SITE | 192 | 192 | Catalytic role in ketonization of the dienol substrate (substrate destabilization) | R |
Size range | 285-296 amino acids |
Related rules | None |
Fusion | None |
Comments | BURCE and COMTE are tagged as atypical due to their sequence similarity to BphD. |