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| Annotation rule MF_01654 |
General rule information
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| Accession | MF_01654 |
| Dates | 30-APR-2008 (Created) 19-NOV-2019 (Last updated, Version 19) |
| Name | MhpC |
| Scope | Bacteria; Proteobacteria |
| Template | P77044 (MHPC_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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| Protein name |
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| Gene name |
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Comments
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| Function | Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid. |
| Catalytic activity | RHEA:34187: (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
EC 3.7.1.14 |
| RHEA:34191: (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
EC 3.7.1.14 |
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| Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
| Subunit | Homodimer. |
| Similarity | Belongs to the MhpC alpha/beta hydrolase family. |
Keywords
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Gene Ontology
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GO:0018771; Molecular function: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity.
GO:0019439; Biological process: aromatic compound catabolic process.
GO:0019439; Biological process: aromatic compound catabolic process.
Cross-references
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Features
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| From: MHPC_ECOLI (P77044) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| ACT_SITE | 267 | 267 | Proton acceptor | H | ||||||||
| SITE | 114 | 114 | Transition state stabilizer | S | ||||||||
| SITE | 192 | 192 | Catalytic role in ketonization of the dienol substrate (substrate destabilization) | R | ||||||||
Additional information
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| Size range | 285-296 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | BURCE and COMTE are tagged as atypical due to their sequence similarity to BphD. |