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Annotation rule MF_01654
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General rule information [?]

Accession MF_01654
Dates 30-APR-2008 (Created)
19-NOV-2019 (Last updated, Version 19)
Name MhpC
Scope
Bacteria; Proteobacteria
Template P77044 (MHPC_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MHPC
Protein name
RecName: Full=2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase;
EC 3.7.1.14;
AltName: Full=2-hydroxy-6-ketonona-2,4-diene-1,9-dioic acid 5,6-hydrolase;
AltName: Full=2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioic acid 5,6-hydrolase;
AltName: Full=2-hydroxy-6-oxonona-2,4-diene-1,9-dioic acid 5,6-hydrolase;
Gene name
mhpC

Comments [?]

Function Catalyzes the cleavage of the C5-C6 bond of 2-hydroxy-6-oxononadienedioate and 2-hydroxy-6-oxononatrienedioate, a dienol ring fission product of the bacterial meta-cleavage pathway for degradation of phenylpropionic acid.
Catalytic activity RHEA:34187: (2Z,4E)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + H(+) + succinate
EC 3.7.1.14
RHEA:34191: (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-trienedioate + H2O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate + H(+)
EC 3.7.1.14
Pathway Aromatic compound metabolism; 3-phenylpropanoate degradation.
Subunit Homodimer.
Similarity Belongs to the MhpC alpha/beta hydrolase family.

Keywords [?]


Gene Ontology [?]

GO:0018771; Molecular function: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;
PRINTS PR00111; ABHYDROLASE; 1;
PR00412; EPOXHYDRLASE; 1;

Features [?]

From: MHPC_ECOLI (P77044)
Key     From     To       Description   Tag   Condition   FTGroup
ACT_SITE     267     267       Proton acceptor     H  
SITE     114     114       Transition state stabilizer     S  
SITE     192     192       Catalytic role in ketonization of the dienol substrate (substrate destabilization)     R  

Additional information [?]

Size range 285-296 amino acids
Related rules None
Fusion None
Comments BURCE and COMTE are tagged as atypical due to their sequence similarity to BphD.