HAMAP rule MF_01657
General rule information
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| Accession | MF_01657 |
| Dates | 5-MAY-2008 (Created) 1-JUN-2023 (Last updated, Version 34) |
| Name | Ac_ald_DH_ac |
| Scope | Bacteria |
| Templates | P77580 (ACDH_ECOLI); Q9KWS1 (ACDH_PSESP); Q79AF6 (ACDH4_PARXL); Q52060 (ACDH_PSEUF); Q53WH9 (ACDH_THET8): [Recover all] |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
|
| Protein name |
|
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case <OC:Enterobacterales>
| Gene name |
|
end case
Comments
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case <OC:Enterobacterales>
| Function | Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds. |
end case
| Catalytic activity | RHEA:23288: acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH
EC 1.2.1.10 |
case <OC:Enterobacterales>
| Pathway | Aromatic compound metabolism; 3-phenylpropanoate degradation. |
| Subunit | Interacts with MhpE. |
end case
| Similarity | Belongs to the acetaldehyde dehydrogenase family. |
Keywords
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Gene Ontology
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GO:0008774; Molecular function: acetaldehyde dehydrogenase (acetylating) activity.
GO:0051287; Molecular function: NAD binding.
GO:0019439; Biological process: aromatic compound catabolic process.
GO:0051287; Molecular function: NAD binding.
GO:0019439; Biological process: aromatic compound catabolic process.
Cross-references
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| Pfam | PF09290; AcetDehyd-dimer; 1; |
| PF01118; Semialdhyde_dh; 1; | |
| NCBIfam | TIGR03215; Ac_ald_DH_ac; 1; |
| PIRSF | PIRSF015689; Actaldh_dh_actl; 1; |
Features
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| From: ACDH_PSEUF (Q52060) | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| BINDING (Optional) | 12 | 15 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [ST]-G-[NDAVS]-[IV] | ||||||||
| BINDING (Optional) | 163 | 171 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | [SG]-x-G-[PI]-[GA]-[TS]-x-x-N | ||||||||
| ACT_SITE | 132 | 132 | Acyl-thioester intermediate | C | ||||||||
| BINDING | 290 | 290 | /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540 | N | ||||||||
Additional information
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| Size range | 262-336 amino acids |
| Related rules | None |
| Fusion | None |
| Comments | This protein is present in multiple copies in some organisms, each one being located in a cluster involved in the degragation of a different aromatic compound. |