HAMAP logo

HAMAP rule MF_01657

Send feedback

General rule information [?]

Accession MF_01657
Dates 5-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 34)
Name Ac_ald_DH_ac
Templates P77580 (ACDH_ECOLI); Q9KWS1 (ACDH_PSESP); Q79AF6 (ACDH4_PARXL); Q52060 (ACDH_PSEUF); Q53WH9 (ACDH_THET8): [Recover all]

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name
RecName: Full=Acetaldehyde dehydrogenase;
AltName: Full=Acetaldehyde dehydrogenase [acetylating];
case <OC:Enterobacterales>
Gene name
end case

Comments [?]

case <OC:Enterobacterales>
Function Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
end case
Catalytic activity RHEA:23288: acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH
case <OC:Enterobacterales>
Pathway Aromatic compound metabolism; 3-phenylpropanoate degradation.
Subunit Interacts with MhpE.
end case
Similarity Belongs to the acetaldehyde dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0008774; Molecular function: acetaldehyde dehydrogenase (acetylating) activity.
GO:0051287; Molecular function: NAD binding.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF09290; AcetDehyd-dimer; 1;
PF01118; Semialdhyde_dh; 1;
NCBIfam TIGR03215; Ac_ald_DH_ac; 1;
PIRSF PIRSF015689; Actaldh_dh_actl; 1;

Features [?]

From: ACDH_PSEUF (Q52060)
Key     From     To       Description   Tag   Condition   FTGroup
BINDING (Optional)     12     15       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [ST]-G-[NDAVS]-[IV]  
BINDING (Optional)     163     171       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     [SG]-x-G-[PI]-[GA]-[TS]-x-x-N  
ACT_SITE     132     132       Acyl-thioester intermediate     C  
BINDING     290     290       /ligand="NAD(+)" /ligand_id="ChEBI:CHEBI:57540     N  

Additional information [?]

Size range 262-336 amino acids
Related rules None
Fusion None
Comments This protein is present in multiple copies in some organisms, each one being located in a cluster involved in the degragation of a different aromatic compound.