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Annotation rule MF_01657
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General rule information [?]

Accession MF_01657
Dates 5-MAY-2008 (Created)
10-JUN-2020 (Last updated, Version 30)
Name Ac_ald_DH_ac
Scope
Bacteria
Templates P77580 (ACDH_ECOLI); Q9KWS1 (ACDH_PSESP); Q79AF6 (ACDH4_PARXL); Q52060 (ACDH_PSEUF); Q53WH9 (ACDH_THET8): [Recover all]

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
ACDH
Protein name
RecName: Full=Acetaldehyde dehydrogenase;
EC 1.2.1.10;
AltName: Full=Acetaldehyde dehydrogenase [acetylating];
case <OC:Enterobacterales>
Gene name
mhpF
end case

Comments [?]

case <OC:Enterobacterales>
Function Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
end case
Catalytic activity RHEA:23288: acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH
EC 1.2.1.10
case <OC:Enterobacterales>
Pathway Aromatic compound metabolism; 3-phenylpropanoate degradation.
Subunit Interacts with MhpE.
end case
Similarity Belongs to the acetaldehyde dehydrogenase family.

Keywords [?]


Gene Ontology [?]

GO:0008774; Molecular function: acetaldehyde dehydrogenase (acetylating) activity.
GO:0051287; Molecular function: NAD binding.
GO:0019439; Biological process: aromatic compound catabolic process.

Cross-references [?]

Pfam PF09290; AcetDehyd-dimer; 1;
PF01118; Semialdhyde_dh; 1;
TIGRFAMs TIGR03215; Ac_ald_DH_ac; 1;
PIRSF PIRSF015689; Actaldh_dh_actl; 1;

Features [?]

From: ACDH_PSEUF (Q52060)
Key     From     To       Description   Tag   Condition   FTGroup
NP_BIND (Optional)     12     15       NAD     [ST]-G-[NDAVS]-[IV]  
NP_BIND (Optional)     163     171       NAD     [SG]-x-G-[PI]-[GA]-[TS]-x-x-N  
ACT_SITE     132     132       Acyl-thioester intermediate     C  
BINDING     290     290       NAD     N  

Additional information [?]

Size range 262-336 amino acids
Related rules None
Fusion None
Comments This protein is present in multiple copies in some organisms, each one being located in a cluster involved in the degragation of a different aromatic compound.