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HAMAP rule MF_01657

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General rule information [?]

Accession MF_01657
Dates 5-MAY-2008 (Created)
12-MAR-2024 (Last updated, Version 36)
Name Ac_ald_DH_ac
Scope(s) Bacteria
Template(s) P77580 (ACDH_ECOLI); Q9KWS1 (ACDH_PSESP); Q79AF6 (ACDH4_PARXL); Q52060 (ACDH_PSEUF); Q53WH9 (ACDH_THET8); [ Recover all ]
Triggered by HAMAP; MF_01657 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier ACDH
Protein name RecName: Full=Acetaldehyde dehydrogenase;
AltName: Full=Acetaldehyde dehydrogenase [acetylating];
case <OC:Enterobacterales>
Gene name Name=mhpF;
end case

Comments [?]

case <OC:Enterobacterales>
FUNCTIONCatalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
end case
CATALYTIC ACTIVITY Reaction=acetaldehyde + CoA + NAD(+) = acetyl-CoA + H(+) + NADH; Xref=Rhea:RHEA:23288, ChEBI:CHEBI:15343, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=;
case <OC:Enterobacterales>
PATHWAYAromatic compound metabolism; 3-phenylpropanoate degradation.
SUBUNITInteracts with MhpE.
end case
SIMILARITYBelongs to the acetaldehyde dehydrogenase family.

Keywords [?]

Gene Ontology [?]

GO:0008774; Molecular function:acetaldehyde dehydrogenase (acetylating) activity
GO:0051287; Molecular function:NAD binding
case <OCellular component:Enterobacterales>
GO:0019380; Biological process:3-phenylpropionate catabolic process
end case

Cross-references [?]

Pfam PF09290; AcetDehyd-dimer; 1;
Pfam PF01118; Semialdhyde_dh; 1;
NCBIfam TIGR03215; Ac_ald_DH_ac; 1;
PIRSF PIRSF015689; Actaldh_dh_actl; 1;

Features [?]

From: ACDH_PSEUF (Q52060)
Key From To Description Tag Condition FTGroup
BINDING 12 15 /ligand="NAD(+)"
BINDING 163 171 /ligand="NAD(+)"
ACT_SITE 132 132 /note="Acyl-thioester intermediate" C
BINDING 290 290 /ligand="NAD(+)"

Additional information [?]

Size range 262-336 amino acids
Related rules None
Fusion Nter: None Cter: None
Comments This protein is present in multiple copies in some organisms, each one being located in a cluster involved in the degragation of a different aromatic compound.

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