HAMAP rule MF_01659
General rule information
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| Accession | MF_01659 |
| Dates | 23-MAY-2008 (Created)
1-JUN-2023 (Last updated, Version 19) |
| Name | MenD |
| Scope(s) |
Bacteria Archaea |
| Template(s) | P17109 (MEND_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01659 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MEND |
| case not <OC:Cyanobacteriota> | |
| Protein name | RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; EC=2.2.1.9; AltName: Full=Menaquinone biosynthesis protein MenD; |
| else case <OC:Cyanobacteriota> | |
| Protein name | RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; EC=2.2.1.9; |
| end case | |
| Gene name | Name=menD; |
Comments
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| FUNCTION | Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). |
| CATALYTIC ACTIVITY | Reaction=2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6- hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2; Xref=Rhea:RHEA:25593, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29780, ChEBI:CHEBI:58818; EC=2.2.1.9; |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; |
| COFACTOR | Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.; |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7. |
| case not <OC:Cyanobacteriota> | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
| end case | |
| SUBUNIT | Homodimer. |
| SIMILARITY | Belongs to the TPP enzyme family. MenD subfamily. |
Keywords
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| Magnesium | |
| Manganese | |
| case not <OC:Cyanobacteriota> | |
| Menaquinone biosynthesis | |
| end case | |
| Metal-binding | |
| Thiamine pyrophosphate | |
| Transferase | |
Gene Ontology
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| GO:0070204; Molecular function:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity | |
| GO:0000287; Molecular function:magnesium ion binding | |
| GO:0030145; Molecular function:manganese ion binding | |
| GO:0030976; Molecular function:thiamine pyrophosphate binding | |
| case not <OCellular component:Cyanobacteriota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0042372; Biological process:phylloquinone biosynthetic process | |
| end case | |
Cross-references
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Features
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Additional information
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| Size range | 497-700 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |