Due to maintenance work, this service will be unavailable from Mon Nov 11 17:30 until Tue Nov 12 09:00 CET. Apologies for the inconvenience.

HAMAP rule MF_01659

General rule information [?]

Accession	MF_01659
Dates	23-MAY-2008 (Created) 1-JUN-2023 (Last updated, Version 19)
Name	MenD
Scope(s)	Bacteria Archaea
Template(s)	P17109 (MEND_ECOLI); [ Recover all ]
Triggered by	HAMAP; MF_01659 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier	MEND
case not <OC:Cyanobacteriota>
Protein name	RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; EC=2.2.1.9; AltName: Full=Menaquinone biosynthesis protein MenD;
else case <OC:Cyanobacteriota>
Protein name	RecName: Full=2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase; Short=SEPHCHC synthase; EC=2.2.1.9;
end case
Gene name	Name=menD;

Comments [?]

FUNCTION	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
CATALYTIC ACTIVITY	Reaction=2-oxoglutarate + H(+) + isochorismate = 5-enolpyruvoyl-6- hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2; Xref=Rhea:RHEA:25593, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:29780, ChEBI:CHEBI:58818; EC=2.2.1.9;
COFACTOR	Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
COFACTOR	Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Note=Binds 1 thiamine pyrophosphate per subunit.;
PATHWAY	Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 2/7.
case not <OC:Cyanobacteriota>
PATHWAY	Quinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteriota>
PATHWAY	Cofactor biosynthesis; phylloquinone biosynthesis.
end case
SUBUNIT	Homodimer.
SIMILARITY	Belongs to the TPP enzyme family. MenD subfamily.

Keywords [?]

Gene Ontology [?]

GO:0070204; Molecular function:2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity
GO:0000287; Molecular function:magnesium ion binding
GO:0030145; Molecular function:manganese ion binding
GO:0030976; Molecular function:thiamine pyrophosphate binding
case not <OCellular component:Cyanobacteriota>
GO:0009234; Biological process:menaquinone biosynthetic process
else case <OCellular component:Cyanobacteriota>
GO:0042372; Biological process:phylloquinone biosynthetic process
end case

Cross-references [?]

Pfam	PF02776; TPP_enzyme_N; 1;
NCBIfam	TIGR00173; MenD; 1;

Features [?]

Additional information [?]