HAMAP rule MF_01660
General rule information
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| Accession | MF_01660 |
| Dates | 23-MAY-2008 (Created) 17-FEB-2023 (Last updated, Version 14) |
| Name | MenH |
| Scope | Bacteria |
| Template | P37355 (MENH_ECOLI) |
| Triggered by |
Propagated annotation
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Identifier, protein and gene names
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| Identifier |
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case <OC:Enterobacterales>
| Protein name |
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else
| Protein name |
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end case
| Gene name |
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Comments
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| Function | Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). |
| Catalytic activity | RHEA:25597: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate
EC 4.2.99.20 |
| Pathway | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7. |
case not <OC:Cyanobacteriota>
| Pathway | Quinol/quinone metabolism; menaquinone biosynthesis. |
else case <OC:Cyanobacteriota>
| Pathway | Cofactor biosynthesis; phylloquinone biosynthesis. |
end case
| Subunit | Monomer. |
| Similarity | Belongs to the AB hydrolase superfamily. MenH family. |
Keywords
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case not <OC:Cyanobacteriota>
end case
Gene Ontology
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GO:0070205; Molecular function: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity.
case not <OC:Cyanobacteriota>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteriota>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case
Cross-references
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| Pfam | PF00561; Abhydrolase_1; 1; |
Additional information
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| Size range | 239-311 amino acids |
| Related rules | None |
| Fusion | None |