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HAMAP rule MF_01660

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General rule information [?]

Accession MF_01660
Dates 23-MAY-2008 (Created)
17-FEB-2023 (Last updated, Version 14)
Name MenH
Scope(s) Bacteria
Template(s) P37355 (MENH_ECOLI); [ Recover all ]
Triggered by HAMAP; MF_01660 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier MENH
case <OC:Enterobacterales>
Protein name RecName: Full=2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
                 Short=SHCHC synthase;
Protein name RecName: Full=Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
                 Short=SHCHC synthase;
end case
Gene name Name=menH;

Comments [?]

FUNCTIONCatalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
CATALYTIC ACTIVITY Reaction=5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1- carboxylate + pyruvate; Xref=Rhea:RHEA:25597, ChEBI:CHEBI:15361, ChEBI:CHEBI:58689, ChEBI:CHEBI:58818; EC=;
PATHWAYQuinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7.
case not <OC:Cyanobacteriota>
PATHWAYQuinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteriota>
PATHWAYCofactor biosynthesis; phylloquinone biosynthesis.
end case
SIMILARITYBelongs to the AB hydrolase superfamily. MenH family.

Keywords [?]

case not <OC:Cyanobacteriota>
Menaquinone biosynthesis
end case

Gene Ontology [?]

GO:0070205; Molecular function:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity
case not <OCellular component:Cyanobacteriota>
GO:0009234; Biological process:menaquinone biosynthetic process
else case <OCellular component:Cyanobacteriota>
GO:0042372; Biological process:phylloquinone biosynthetic process
end case

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;

Features [?]

Additional information [?]

Size range 239-311 amino acids
Related rules None
Fusion Nter: None Cter: None

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