HAMAP rule MF_01660
General rule information
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| Accession | MF_01660 |
| Dates | 23-MAY-2008 (Created)
17-FEB-2023 (Last updated, Version 14) |
| Name | MenH |
| Scope(s) |
Bacteria |
| Template(s) | P37355 (MENH_ECOLI); [ Recover all ] |
| Triggered by |
HAMAP; MF_01660 (Get profile general information and statistics) |
Propagated annotation
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Identifier, protein and gene names
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| Identifier | MENH |
| case <OC:Enterobacterales> | |
| Protein name | RecName: Full=2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Short=SHCHC synthase; EC=4.2.99.20; |
| else | |
| Protein name | RecName: Full=Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase; Short=SHCHC synthase; EC=4.2.99.20; |
| end case | |
| Gene name | Name=menH; |
Comments
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| FUNCTION | Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). |
| CATALYTIC ACTIVITY | Reaction=5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1- carboxylate + pyruvate; Xref=Rhea:RHEA:25597, ChEBI:CHEBI:15361, ChEBI:CHEBI:58689, ChEBI:CHEBI:58818; EC=4.2.99.20; |
| PATHWAY | Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7. |
| case not <OC:Cyanobacteriota> | |
| PATHWAY | Quinol/quinone metabolism; menaquinone biosynthesis. |
| else case <OC:Cyanobacteriota> | |
| PATHWAY | Cofactor biosynthesis; phylloquinone biosynthesis. |
| end case | |
| SUBUNIT | Monomer. |
| SIMILARITY | Belongs to the AB hydrolase superfamily. MenH family. |
Keywords
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| Lyase | |
| case not <OC:Cyanobacteriota> | |
| Menaquinone biosynthesis | |
| end case | |
Gene Ontology
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| GO:0070205; Molecular function:2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity | |
| case not <OCellular component:Cyanobacteriota> | |
| GO:0009234; Biological process:menaquinone biosynthetic process | |
| else case <OCellular component:Cyanobacteriota> | |
| GO:0042372; Biological process:phylloquinone biosynthetic process | |
| end case | |
Cross-references
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| Pfam | PF00561; Abhydrolase_1; 1; |
Features
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Additional information
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| Size range | 239-311 amino acids |
| Related rules |
None |
| Fusion | Nter: None Cter: None |