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Annotation rule MF_01660
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General rule information [?]

Accession MF_01660
Dates 23-MAY-2008 (Created)
19-NOV-2019 (Last updated, Version 13)
Name MenH
Scope
Bacteria
Template P37355 (MENH_ECOLI)

Propagated annotation [?]


Identifier, protein and gene names [?]

Identifier
MENH
case <OC:Enterobacterales>
Protein name
RecName: Full=2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
Short=SHCHC synthase;
EC 4.2.99.20;
else
Protein name
RecName: Full=Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase;
Short=SHCHC synthase;
EC 4.2.99.20;
end case
Gene name
menH

Comments [?]

Function Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC).
Catalytic activity RHEA:25597: 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate = (1R,6R)-6-hydroxy-2-succinyl-cyclohexa-2,4-diene-1-carboxylate + pyruvate
EC 4.2.99.20
Pathway Quinol/quinone metabolism; 1,4-dihydroxy-2-naphthoate biosynthesis; 1,4-dihydroxy-2-naphthoate from chorismate: step 3/7.
case not <OC:Cyanobacteria>
Pathway Quinol/quinone metabolism; menaquinone biosynthesis.
else case <OC:Cyanobacteria>
Pathway Cofactor biosynthesis; phylloquinone biosynthesis.
end case
Subunit Monomer.
Similarity Belongs to the AB hydrolase superfamily. MenH family.

Keywords [?]

case not <OC:Cyanobacteria>
end case

Gene Ontology [?]

GO:0070205; Molecular function: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase activity.
case not <OC:Cyanobacteria>
GO:0009234; Biological process: menaquinone biosynthetic process.
else case <OC:Cyanobacteria>
GO:0042372; Biological process: phylloquinone biosynthetic process.
end case

Cross-references [?]

Pfam PF00561; Abhydrolase_1; 1;

Additional information [?]

Size range 239-311 amino acids
Related rules None
Fusion None