HAMAP rule MF_01664

General rule information [?]

Accession	MF_01664
Dates	8-JUL-2008 (Created) 13-JAN-2023 (Last updated, Version 15)

Name	HemeA_synth_type1

Scope

Bacteria; Bacillota

Template

P12946 (CTAA_BACSU)

Triggered by

HAMAP; MF_01664 (Get profile general information and statistics)

Propagated annotation [?]

Identifier, protein and gene names [?]

Identifier

CTAA

Protein name

RecName:		Full=Heme A synthase;
		Short=HAS;
		EC 1.17.99.9;
AltName:		Full=Cytochrome aa3-controlling protein;

Gene name

ctaA

Comments [?]

Function	Catalyzes the conversion of heme O to heme A by two successive hydroxylations of the methyl group at C8. The first hydroxylation forms heme I, the second hydroxylation results in an unstable dihydroxymethyl group, which spontaneously dehydrates, resulting in the formyl group of heme A.
Catalytic activity	RHEA:63388: 2 A + Fe(II)-heme o + H2O = 2 AH2 + Fe(II)-heme a EC 1.17.99.9 PhysiologicalDirection=left-to-right (RHEA:63389)
Cofactor	heme b
Pathway	Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.
Subunit	Interacts with CtaB.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Similarity	Belongs to the COX15/CtaA family. Type 1 subfamily.

Keywords [?]

Cell membrane
Heme biosynthesis
Iron
Membrane
Metal-binding
Oxidoreductase
Transmembrane
Transmembrane helix

Gene Ontology [?]

GO:0006784; Biological process: heme A biosynthetic process.
GO:0005886; Cellular component: plasma membrane.

Cross-references [?]

Pfam	PF02628; COX15-CtaA; 1;

Computed features [?]

General

Transmembrane; -; 8; trigger=yes;

Features [?]

From: CTAA_BACSU (P12946)

Key From To Description Tag Condition FTGroup

BINDING 216 216 /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue H

BINDING 278 278 /ligand="heme" /ligand_id="ChEBI:CHEBI:30413" /ligand_part="Fe" /ligand_part_id="ChEBI:CHEBI:18248" /note="axial binding residue H

Additional information [?]

Size range	297-317 amino acids
Related rules	MF_01665 (CTAA)
Fusion	None
Comments	COX15/CtaA type 2 subfamily in MF_01665.

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